The Protective Effect of a Newly Developed Molecular Chaperone– Inducer Against Mouse Ischemic Acute Kidney Injury

Activation of the unfolded protein response (UPR) has been suggested to attenuate renal ischemia-reperfusion (I/R) injury. We recently found a compound, namely BIX, that activated the UPR selectively through the activating transcription factor 6 pathway. This study examined the effect of BIX on rena...

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Published inJournal of Pharmacological Sciences Vol. 109; no. 2; pp. 311 - 314
Main Authors Prachasilchai, Worapat, Sonoda, Hiroko, Yokota-Ikeda, Naoko, Ito, Katsuaki, Kudo, Takashi, Imaizumi, Kazunori, Ikeda, Masahiro
Format Journal Article
LanguageEnglish
Published Japan Elsevier B.V 2009
The Japanese Pharmacological Society
Elsevier
Subjects
Animals
endoplasmic reticulum (ER) stress
Heat-Shock Proteins - genetics
Heat-Shock Proteins - metabolism
Ischemia - drug therapy
Kidney - injuries
Male
Mice
Mice, Inbred Strains
Molecular Chaperones - genetics
Molecular Chaperones - metabolism
renal ischemia-reperfusion injury
Reperfusion Injury - prevention & control
RNA, Messenger - metabolism
Thiocyanates - therapeutic use
Transcriptional Activation
Tunicamycin - administration & dosage
Tunicamycin - pharmacology
unfolded protein response
Up-Regulation
unfolded protein response
endoplasmic reticulum (ER) stress
renal ischemia-reperfusion injury
Online AccessGet full text
ISSN1347-8613
1347-8648
DOI10.1254/jphs.08272SC

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Abstract Activation of the unfolded protein response (UPR) has been suggested to attenuate renal ischemia-reperfusion (I/R) injury. We recently found a compound, namely BIX, that activated the UPR selectively through the activating transcription factor 6 pathway. This study examined the effect of BIX on renal I/R injury in mice. BIX selectively up-regulated renal BiP mRNA and protein. Pretreatment with BIX significantly ameliorated renal I/R injury. Coadministration of BIX and tunicamycin, a non-selective UPR inducer, provided no additional protection. Our results suggest that the UPR activation by BIX leads to a novel drug therapy against renal I/R injury.
AbstractList Activation of the unfolded protein response (UPR) has been suggested to attenuate renal ischemia-reperfusion (I/R) injury. We recently found a compound, namely BIX, that activated the UPR selectively through the activating transcription factor 6 pathway. This study examined the effect of BIX on renal I/R injury in mice. BIX selectively up-regulated renal BiP mRNA and protein. Pretreatment with BIX significantly ameliorated renal I/R injury. Co-administration of BIX and tunicamycin, a non-selective UPR inducer, provided no additional protection. Our results suggest that the UPR activation by BIX leads to a novel drug therapy against renal I/R injury.
Activation of the unfolded protein response (UPR) has been suggested to attenuate renal ischemia-reperfusion (I/R) injury. We recently found a compound, namely BIX, that activated the UPR selectively through the activating transcription factor 6 pathway. This study examined the effect of BIX on renal I/R injury in mice. BIX selectively up-regulated renal BiP mRNA and protein. Pretreatment with BIX significantly ameliorated renal I/R injury. Coadministration of BIX and tunicamycin, a non-selective UPR inducer, provided no additional protection. Our results suggest that the UPR activation by BIX leads to a novel drug therapy against renal I/R injury.
Activation of the unfolded protein response (UPR) has been suggested to attenuate renal ischemia-reperfusion (I/R) injury. We recently found a compound, namely BIX, that activated the UPR selectively through the activating transcription factor 6 pathway. This study examined the effect of BIX on renal I/R injury in mice. BIX selectively up-regulated renal BiP mRNA and protein. Pretreatment with BIX significantly ameliorated renal I/R injury. Coadministration of BIX and tunicamycin, a non-selective UPR inducer, provided no additional protection. Our results suggest that the UPR activation by BIX leads to a novel drug therapy against renal I/R injury. Keywords:: renal ischemia-reperfusion injury, endoplasmic reticulum (ER) stress, unfolded protein response
Activation of the unfolded protein response (UPR) has been suggested to attenuate renal ischemia-reperfusion (I/R) injury. We recently found a compound, namely BIX, that activated the UPR selectively through the activating transcription factor 6 pathway. This study examined the effect of BIX on renal I/R injury in mice. BIX selectively up-regulated renal BiP mRNA and protein. Pretreatment with BIX significantly ameliorated renal I/R injury. Co-administration of BIX and tunicamycin, a non-selective UPR inducer, provided no additional protection. Our results suggest that the UPR activation by BIX leads to a novel drug therapy against renal I/R injury.Activation of the unfolded protein response (UPR) has been suggested to attenuate renal ischemia-reperfusion (I/R) injury. We recently found a compound, namely BIX, that activated the UPR selectively through the activating transcription factor 6 pathway. This study examined the effect of BIX on renal I/R injury in mice. BIX selectively up-regulated renal BiP mRNA and protein. Pretreatment with BIX significantly ameliorated renal I/R injury. Co-administration of BIX and tunicamycin, a non-selective UPR inducer, provided no additional protection. Our results suggest that the UPR activation by BIX leads to a novel drug therapy against renal I/R injury.
Abstract. Activation of the unfolded protein response (UPR) has been suggested to attenuate renal ischemia-reperfusion (I/R) injury. We recently found a compound, namely BIX, that activated the UPR selectively through the activating transcription factor 6 pathway. This study examined the effect of BIX on renal I/R injury in mice. BIX selectively up-regulated renal BiP mRNA and protein. Pretreatment with BIX significantly ameliorated renal I/R injury. Co-administration of BIX and tunicamycin, a non-selective UPR inducer, provided no additional protection. Our results suggest that the UPR activation by BIX leads to a novel drug therapy against renal I/R injury.
Author Ito, Katsuaki
Prachasilchai, Worapat
Kudo, Takashi
Yokota-Ikeda, Naoko
Sonoda, Hiroko
Imaizumi, Kazunori
Ikeda, Masahiro
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  givenname: Masahiro
  surname: Ikeda
  fullname: Ikeda, Masahiro
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  organization: Department of Veterinary Pharmacology, Faculty of Agriculture, University of Miyazaki, Miyazaki 889-2192, Japan
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Cites_doi 10.1158/1541-7786.MCR-05-0221
10.1152/ajprenal.1999.277.2.F211
10.1038/ki.2008.210
10.1146/annurev.biochem.73.011303.074134
10.1016/j.bbrc.2004.07.097
10.1016/j.drudis.2006.02.010
10.1016/j.toxlet.2003.12.066
10.1111/j.1742-4658.2007.05639.x
10.1681/ASN.2006010017
10.1016/j.ejphar.2008.06.108
10.1038/sj.cdd.4402276
10.1016/j.brainres.2008.02.068
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endoplasmic reticulum (ER) stress
renal ischemia-reperfusion injury
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References 2 Feldman DE, Chauhan V, Koong AC. The unfolded protein response: a novel component of the hypoxic stress response in tumors. Mol Cancer Res. 2005;3:597–605.
6 Bush KT, George SK, Zhang PL, Nigam SK. Pretreatment with inducers of ER molecular chaperones protects epithelial cells subjected to ATP depletion. Am J Physiol Renal Physiol. 1999;277:F211–F218.
4 Devarajan P. Update on mechanisms of ischemic acute kidney injury. J Am Soc Nephrol. 2006;17:1503–1520.
8 Prachasilchai W, Sonoda H, Yokota-Ikeda N, Oshikawa S, Aikawa C, Uchida K, et al. A protective role of unfolded protein response in mouse ischemic acute kidney injury. Eur J Pharmacol. 2008;592:138–145.
10 Oida Y, Izuta H, Oyagi A, Shimazawa M, Kudo T, Imaizumi K, et al. Induction of BiP, an ER-resident protein, prevents the neuronal death induced by transient forebrain ischemia in gerbil. Brain Res. 2008;1208:217–224.
11 Sharyo S, Yokota-Ikeda N, Mori M, Kumagai K, Uchida K, Ito K, et al. Pravastatin improves renal ischemia-reperfusion injury by inhibiting the mevalonate pathway. Kidney Int. 2008;74:577–584.
3 Yoshida H. ER stress and diseases. FEBS J. 2007;274:630–658.
12 Kondoh M, Tsukada M, Kuronaga M, Higashimoto M, Takiguchi M, Himeno S, et al. Induction of hepatic metallothionein synthesis by endoplasmic reticulum stress in mice. Toxicol Lett. 2004;148:133–139.
5 Ikeda M, Prachasilchai W, Burne-Taney MJ, Rabb H, Yokota-Ikeda N. Ischemic acute tubular necrosis models and drug discovery: a focus on cellular inflammation. Drug Discov Today. 2006;11:364–370.
7 George SK, Meyer TN, Abdeen O, Bush KT, Nigam SK. Tunicamycin preserves intercellular junctions, cytoarchitecture, and cell-substratum interactions in ATP-depleted epithelial cells. Biochem Biophys Res Commun. 2004;322:223–231.
1 Schröder M, Kaufman RJ. The mammalian unfolded protein response. Annu Rev Biochem. 2005;74:739–789.
9 Kudo T, Kanemoto S, Hara H, Morimoto N, Morihara T, Kimura R, et al. A molecular chaperone inducer protects neurons from ER stress. Cell Death Differ. 2008;15:364–375.
11
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References_xml – reference: 6 Bush KT, George SK, Zhang PL, Nigam SK. Pretreatment with inducers of ER molecular chaperones protects epithelial cells subjected to ATP depletion. Am J Physiol Renal Physiol. 1999;277:F211–F218.
– reference: 1 Schröder M, Kaufman RJ. The mammalian unfolded protein response. Annu Rev Biochem. 2005;74:739–789.
– reference: 7 George SK, Meyer TN, Abdeen O, Bush KT, Nigam SK. Tunicamycin preserves intercellular junctions, cytoarchitecture, and cell-substratum interactions in ATP-depleted epithelial cells. Biochem Biophys Res Commun. 2004;322:223–231.
– reference: 9 Kudo T, Kanemoto S, Hara H, Morimoto N, Morihara T, Kimura R, et al. A molecular chaperone inducer protects neurons from ER stress. Cell Death Differ. 2008;15:364–375.
– reference: 11 Sharyo S, Yokota-Ikeda N, Mori M, Kumagai K, Uchida K, Ito K, et al. Pravastatin improves renal ischemia-reperfusion injury by inhibiting the mevalonate pathway. Kidney Int. 2008;74:577–584.
– reference: 12 Kondoh M, Tsukada M, Kuronaga M, Higashimoto M, Takiguchi M, Himeno S, et al. Induction of hepatic metallothionein synthesis by endoplasmic reticulum stress in mice. Toxicol Lett. 2004;148:133–139.
– reference: 10 Oida Y, Izuta H, Oyagi A, Shimazawa M, Kudo T, Imaizumi K, et al. Induction of BiP, an ER-resident protein, prevents the neuronal death induced by transient forebrain ischemia in gerbil. Brain Res. 2008;1208:217–224.
– reference: 3 Yoshida H. ER stress and diseases. FEBS J. 2007;274:630–658.
– reference: 8 Prachasilchai W, Sonoda H, Yokota-Ikeda N, Oshikawa S, Aikawa C, Uchida K, et al. A protective role of unfolded protein response in mouse ischemic acute kidney injury. Eur J Pharmacol. 2008;592:138–145.
– reference: 2 Feldman DE, Chauhan V, Koong AC. The unfolded protein response: a novel component of the hypoxic stress response in tumors. Mol Cancer Res. 2005;3:597–605.
– reference: 4 Devarajan P. Update on mechanisms of ischemic acute kidney injury. J Am Soc Nephrol. 2006;17:1503–1520.
– reference: 5 Ikeda M, Prachasilchai W, Burne-Taney MJ, Rabb H, Yokota-Ikeda N. Ischemic acute tubular necrosis models and drug discovery: a focus on cellular inflammation. Drug Discov Today. 2006;11:364–370.
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Snippet Activation of the unfolded protein response (UPR) has been suggested to attenuate renal ischemia-reperfusion (I/R) injury. We recently found a compound, namely...
Abstract. Activation of the unfolded protein response (UPR) has been suggested to attenuate renal ischemia-reperfusion (I/R) injury. We recently found a...
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SubjectTerms Animals
endoplasmic reticulum (ER) stress
Heat-Shock Proteins - genetics
Heat-Shock Proteins - metabolism
Ischemia - drug therapy
Kidney - injuries
Male
Mice
Mice, Inbred Strains
Molecular Chaperones - genetics
Molecular Chaperones - metabolism
renal ischemia-reperfusion injury
Reperfusion Injury - prevention & control
RNA, Messenger - metabolism
Thiocyanates - therapeutic use
Transcriptional Activation
Tunicamycin - administration & dosage
Tunicamycin - pharmacology
unfolded protein response
Up-Regulation
Title The Protective Effect of a Newly Developed Molecular Chaperone– Inducer Against Mouse Ischemic Acute Kidney Injury
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Volume 109
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ispartofPNX Journal of Pharmacological Sciences, 2009, Vol.109(2), pp.311-314
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