Successful N-Acetylcysteine Treatment of Trimethoprim/Sulfamethoxazole-Induced Acute Liver Injury 2235

• Published in: The American journal of gastroenterology Vol. 113; no. Supplement; p. S1269
• Main Authors: Ryan-Fisher, Courtenay, Rawi, Sarah, Sachdev, Rishabh, Vinsard, Daniela G.
• Format: Journal Article
• Language: English
• Published: New York Wolters Kluwer Health Medical Research, Lippincott Williams & Wilkins 01.10.2018
• Subjects: Abdomen; Analgesics; Antibiotics; Drug overdose; Gastroenterology; Liver; Recreational drugs

Trimethoprim/Sulfamethoxazole (TMP/SMX) causes hepatotoxicity, defined as a two-fold increase in aminotransferase or total bilirubin.1 TMP/SMX contains propylene glycol, a solvent metabolized in the liver to lactic acid, leading to lactic acidosis.2 A previously healthy 23-year-old female presented...