Simultaneous activation of complement and coagulation by MBL-associated serine protease 2

• Published in: PloS one Vol. 2; no. 7; p. e623
• Main Authors: Krarup, Anders, Wallis, Russell, Presanis, Julia S, Gál, Péter, Sim, Robert B
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 18.07.2007; Public Library of Science (PLoS)
• Subjects: Animals; Bacteria; Biochemistry; Biochemistry/Macromolecular Chemistry; Blood Coagulation - genetics; Blood Coagulation - physiology; Clotting; Coagulation; Coagulation factors; Complement; Complement activation; Complement Activation - physiology; Complement component C2; Complement component C4; Cricetinae; Crosslinking; Enzymes; Factor Xa - genetics; Factor Xa - metabolism; Factor XIII - metabolism; Fibrin; Fibrin - metabolism; Fibrinogen; Fibrinogen - metabolism; Foreign bodies; Hematology; Immune response; Immune system; Immunology; Immunology/Immunity to Infections; Immunology/Innate Immunity; Innate immunity; Invertebrates; Lectins; Mannan; Mannose-binding lectin; Mannose-Binding Lectin - metabolism; Mannose-Binding Protein-Associated Serine Proteases - genetics; Mannose-Binding Protein-Associated Serine Proteases - metabolism; MASP-2 protein; Membranes; Microorganisms; Pathogens; Peptide Fragments - metabolism; Polypeptides; Protease; Proteases; Proteins; Prothrombin; Prothrombin - genetics; Prothrombin - metabolism; Serine; Serine proteinase; Thrombin

The complement system is an important immune mechanism mediating both recognition and elimination of foreign bodies. The lectin pathway is one pathway of three by which the complement system is activated. The characteristic protease of this pathway is Mannan-binding lectin (MBL)-associated serine pr...