Identification of a novel CDK9 inhibitor targeting the intramolecular hidden cavity of CDK9 induced by Tat binding - Asamitsu, Kaori; Hirokawa, Takatsugu; Okamoto, Takashi (PloS one, 2022)
Keywords: Amino acid sequence; Amino acids; Analysis; Antiviral agents; Binding; Biology and Life Sciences; Care and treatment; Chromatography; Complications and side effects; Cyclin T1; Cyclin-dependent kinase 9; Cyclin-dependent kinases; Cytotoxicity; Elongation; Gene expression; GLP-1 receptor agonists; Glutathione; Highly active antiretroviral therapy; HIV; HIV (Viruses); Human immunodeficiency virus; Inhibitors; Kinases; Medicine and Health Sciences; Molecular dynamics; Molecular structure; Patient outcomes; Peptides; Phosphorylation; Physical Sciences; Proteins; Research and Analysis Methods; RNA polymerase; Simulation; Tat protein; Therapeutic targets; Toxicity; Japan