Identification of ten loci associated with height highlights new biological pathways in human growth
Height is a classic polygenic trait, reflecting the combined influence of multiple as-yet-undiscovered genetic factors. We carried out a meta-analysis of genome-wide association study data of height from 15,821 individuals at 2.2 million SNPs, and followed up the strongest findings in >10,000 sub...
Saved in:
| Published in | Nature genetics Vol. 40; no. 5; pp. 584 - 591 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
New York
Nature Publishing Group US
01.05.2008
Nature Publishing Group |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1061-4036 1546-1718 1546-1718 |
| DOI | 10.1038/ng.125 |
Cover
Loading…
| Abstract | Height is a classic polygenic trait, reflecting the combined influence of multiple as-yet-undiscovered genetic factors. We carried out a meta-analysis of genome-wide association study data of height from 15,821 individuals at 2.2 million SNPs, and followed up the strongest findings in >10,000 subjects. Ten newly identified and two previously reported loci were strongly associated with variation in height (
P
values from 4 × 10
−7
to 8 × 10
−22
). Together, these 12 loci account for ∼2% of the population variation in height. Individuals with ≤8 height-increasing alleles and ≥16 height-increasing alleles differ in height by ∼3.5 cm. The newly identified loci, along with several additional loci with strongly suggestive associations, encompass both strong biological candidates and unexpected genes, and highlight several pathways (
let-7
targets, chromatin remodeling proteins and Hedgehog signaling) as important regulators of human stature. These results expand the picture of the biological regulation of human height and of the genetic architecture of this classical complex trait. |
|---|---|
| AbstractList | Height is a classic polygenic trait, reflecting the combined influence of multiple as-yet- undiscovered genetic factors. We carried out a meta-analysis of genome-wide association study data of height from 15,821 individuals at 2.2 million SNPs, and followed up the strongest findings in 410,000 subjects. Ten newly identified and two previously reported loci were strongly associated with variation in height (P values from 4 x 10(-7) to 8 x 10(-22)). Together, these 12 loci account for similar to 2% of the population variation in height. Individuals with <= 8 height-increasing alleles and >= 16 height-increasing alleles differ in height by similar to 3.5 cm. The newly identified loci, along with several additional loci with strongly suggestive associations, encompass both strong biological candidates and unexpected genes, and highlight several pathways (let-7 targets, chromatin remodeling proteins and Hedgehog signaling) as important regulators of human stature. These results expand the picture of the biological regulation of human height and of the genetic architecture of this classical complex trait. Height is a classic polygenic trait, reflecting the combined influence of multiple as-yet-undiscovered genetic factors. We carried out a meta-analysis of genome-wide association study data of height from 15,821 individuals at 2.2 million SNPs, and followed up the strongest findings in >10,000 subjects. ten newly identified and two previously reported loci were strongly associated with variation in height (P values from 4 [math] 10 super(- 7) to 8 [math] 10 super(- 22)). Together, these 12 loci account for [math]2% of the population variation in height. Individuals with [less]8 height-increasing alleles and [greater]16 height-increasing alleles differ in height by [math]3.5 cm. The newly identified loci, along with several additional loci with strongly suggestive associations, encompass both strong biological candidates and unexpected genes, and highlight several pathways (let-7 targets, chromatin remodeling proteins and Hedgehog signaling) as important regulators of human stature. These results expand the picture of the biological regulation of human height and of the genetic architecture of this classical complex trait. Height is a classic polygenic trait, reflecting the combined influence of multiple as-yet-undiscovered genetic factors. We carried out a meta-analysis of genome-wide association study data of height from 15,821 individuals at 2.2 million SNPs, and followed up the strongest findings in >10,000 subjects. Ten newly identified and two previously reported loci were strongly associated with variation in height (P values from 4 x 10(-7) to 8 x 10(-22)). Together, these 12 loci account for approximately 2% of the population variation in height. Individuals with < or =8 height-increasing alleles and > or =16 height-increasing alleles differ in height by approximately 3.5 cm. The newly identified loci, along with several additional loci with strongly suggestive associations, encompass both strong biological candidates and unexpected genes, and highlight several pathways (let-7 targets, chromatin remodeling proteins and Hedgehog signaling) as important regulators of human stature. These results expand the picture of the biological regulation of human height and of the genetic architecture of this classical complex trait. Height is a classic polygenic trait, reflecting the combined influence of multiple as-yet-undiscovered genetic factors. We carried out a meta-analysis of genome-wide association study data of height from 15,821 individuals at 2.2 million SNPs, and followed up the strongest findings in >10,000 subjects. Ten newly identified and two previously reported loci were strongly associated with variation in height ( P values from 4 × 10 -7 to 8 × 10 -22 ). Together, these 12 loci account for ~2% of the population variation in height. Individuals with ≤8 height-increasing alleles and ≥16 height-increasing alleles differ in height by ~3.5 cm. The newly identified loci, along with several additional loci with strongly suggestive associations, encompass both strong biological candidates and unexpected genes, and highlight several pathways ( let-7 targets, chromatin remodeling proteins and Hedgehog signaling) as important regulators of human stature. These results expand the picture of the biological regulation of human height and of the genetic architecture of this classical complex trait. Height is a classic polygenic trait, reflecting the combined influence of multiple as-yet-undiscovered genetic factors. We carried out a meta-analysis of genome-wide association study data of height from 15,821 individuals at 2.2 million SNPs, and followed up the strongest findings in >10,000 subjects. Ten newly identified and two previously reported loci were strongly associated with variation in height (P values from 4 × 10^sup -7^ to 8 × 10^sup -22^). Together, these 12 loci account for ~2% of the population variation in height. Individuals with ≤8 height-increasing alleles and ≥16 height-increasing alleles differ in height by ~3.5 cm. The newly identified loci, along with several additional loci with strongly suggestive associations, encompass both strong biological candidates and unexpected genes, and highlight several pathways (let-7 targets, chromatin remodeling proteins and Hedgehog signaling) as important regulators of human stature. These results expand the picture of the biological regulation of human height and of the genetic architecture of this classical complex trait. [PUBLICATION ABSTRACT] Height is a classic polygenic trait, reflecting the combined influence of multiple as-yet- undiscovered genetic factors. We carried out a meta-analysis of genome-wide association study data of height from 15,821 individuals at 2.2 million SNPs, and followed up the strongest findings in 410,000 subjects. Ten newly identified and two previously reported loci were strongly associated with variation in height (P values from 4 x 10(-7) to 8 x 10(-22)). Together, these 12 loci account for similar to 2% of the population variation in height. Individuals with <= 8 height-increasing alleles and >= 16 height-increasing alleles differ in height by similar to 3.5 cm. The newly identified loci, along with several additional loci with strongly suggestive associations, encompass both strong biological candidates and unexpected genes, and highlight several pathways (let-7 targets, chromatin remodeling proteins and Hedgehog signaling) as important regulators of human stature. These results expand the picture of the biologicalregulation of human height and of the genetic architecture of this classical complex trait. Height is a classic polygenic trait, reflecting the combined influence of multiple as-yet-undiscovered genetic factors. We carried out a meta-analysis of genome-wide association study data of height from 15,821 individuals at 2.2 million SNPs, and followed up the strongest findings in >10,000 subjects. Ten newly identified and two previously reported loci were strongly associated with variation in height (P values from 4 x 10(-7) to 8 x 10(-22)). Together, these 12 loci account for approximately 2% of the population variation in height. Individuals with < or =8 height-increasing alleles and > or =16 height-increasing alleles differ in height by approximately 3.5 cm. The newly identified loci, along with several additional loci with strongly suggestive associations, encompass both strong biological candidates and unexpected genes, and highlight several pathways (let-7 targets, chromatin remodeling proteins and Hedgehog signaling) as important regulators of human stature. These results expand the picture of the biological regulation of human height and of the genetic architecture of this classical complex trait.Height is a classic polygenic trait, reflecting the combined influence of multiple as-yet-undiscovered genetic factors. We carried out a meta-analysis of genome-wide association study data of height from 15,821 individuals at 2.2 million SNPs, and followed up the strongest findings in >10,000 subjects. Ten newly identified and two previously reported loci were strongly associated with variation in height (P values from 4 x 10(-7) to 8 x 10(-22)). Together, these 12 loci account for approximately 2% of the population variation in height. Individuals with < or =8 height-increasing alleles and > or =16 height-increasing alleles differ in height by approximately 3.5 cm. The newly identified loci, along with several additional loci with strongly suggestive associations, encompass both strong biological candidates and unexpected genes, and highlight several pathways (let-7 targets, chromatin remodeling proteins and Hedgehog signaling) as important regulators of human stature. These results expand the picture of the biological regulation of human height and of the genetic architecture of this classical complex trait. Height is a classic polygenic trait, reflecting the combined influence of multiple as-yet-undiscovered genetic factors. We carried out a meta-analysis of genome-wide association study data of height from 15,821 individuals at 2.2 million SNPs, and followed up the strongest findings in >10,000 subjects. Ten newly identified and two previously reported loci were strongly associated with variation in height ( P values from 4 × 10 −7 to 8 × 10 −22 ). Together, these 12 loci account for ∼2% of the population variation in height. Individuals with ≤8 height-increasing alleles and ≥16 height-increasing alleles differ in height by ∼3.5 cm. The newly identified loci, along with several additional loci with strongly suggestive associations, encompass both strong biological candidates and unexpected genes, and highlight several pathways ( let-7 targets, chromatin remodeling proteins and Hedgehog signaling) as important regulators of human stature. These results expand the picture of the biological regulation of human height and of the genetic architecture of this classical complex trait. |
| Audience | Academic |
| Author | Hu, Frank B Schumacher, Fredrick R Boehnke, Michael Mohlke, Karen L Schlessinger, David Illig, Thomas Hirschhorn, Joel N Hackett, Rachel Sanna, Serena Butler, Johannah L Voight, Benjamin F Lyssenko, Valeriya Hayes, Richard B Berndt, Sonja I Heid, Iris M Gieger, Christian Salomaa, Veikko Uda, Manuela Groop, Leif C Jacobs, Kevin B Isomaa, Bo Jackson, Anne U Guiducci, Candace Lettre, Guillaume Chanock, Stephen J Kraft, Peter Wichmann, H-Erich Peltonen, Leena Eyheramendy, Susana Hunter, David J Abecasis, Gonçalo R |
| AuthorAffiliation | 12 Department of Clinical Sciences, Diabetes and Endocrinology, University Hospital Malmö, Lund University, 205 02 Malmö, Sweden 18 Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK 22 Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599, USA 19 Department of Molecular Medicine, National Public Health Institute and Department of Medical Genetics, University of Helsinki, FI-00014 Helsinki, Finland 21 Gerontology Research Center, National Institute on Aging, 5600 Nathan Shock Drive, Baltimore, Maryland 21224, USA 6 Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA 5 Department of Epidemiology, Institute of Medical Informatics, Biometry and Epidemiology, University of Munich, 81377 Munich, Germany 15 Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA 3 Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann |
| AuthorAffiliation_xml | – name: 6 Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA – name: 19 Department of Molecular Medicine, National Public Health Institute and Department of Medical Genetics, University of Helsinki, FI-00014 Helsinki, Finland – name: 18 Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK – name: 16 Malmska Municipal Health Center and Hospital, Jakobstad, Finland – name: 17 Folkhälsan Research Center, Helsinki, Finland – name: 20 Department of Epidemiology and Health Promotion. National Public Health Institute, FI-00300 Helsinki, Finland – name: 15 Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA – name: 21 Gerontology Research Center, National Institute on Aging, 5600 Nathan Shock Drive, Baltimore, Maryland 21224, USA – name: 2 Divisions of Genetics and Endocrinology and Program in Genomics, Children’s Hospital, Boston, Massachusetts 02115, USA – name: 8 Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Bethesda, Maryland 20892, USA – name: 13 Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, NCI, NIH, DHHS, Bethesda, Maryland 20892, USA – name: 1 Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA – name: 12 Department of Clinical Sciences, Diabetes and Endocrinology, University Hospital Malmö, Lund University, 205 02 Malmö, Sweden – name: 23 Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA – name: 10 Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA – name: 14 Department of Medicine, Helsinki University Central Hospital, and Research Program for Molecular Medicine, University of Helsinki, Helsinki, Finland – name: 7 Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA – name: 9 Istituto di Neurogenetica e Neurofarmacologia (INN), Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari 09042, Italy – name: 11 Bioinformed Consulting Services, Gaithersburg, Maryland 20877, USA – name: 3 Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA – name: 5 Department of Epidemiology, Institute of Medical Informatics, Biometry and Epidemiology, University of Munich, 81377 Munich, Germany – name: 22 Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599, USA – name: 4 Institute of Epidemiology, GSF National Research Center for Environment and Health, 85764 Neuherberg, Germany |
| Author_xml | – sequence: 1 givenname: Guillaume surname: Lettre fullname: Lettre, Guillaume organization: Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Divisions of Genetics and Endocrinology and Program in Genomics, Children's Hospital – sequence: 2 givenname: Anne U surname: Jackson fullname: Jackson, Anne U organization: Department of Biostatistics, Center for Statistical Genetics, University of Michigan – sequence: 3 givenname: Christian surname: Gieger fullname: Gieger, Christian organization: Institute of Epidemiology, GSF National Research Center for Environment and Health, Department of Epidemiology, Institute of Medical Informatics, Biometry and Epidemiology, University of Munich – sequence: 4 givenname: Fredrick R surname: Schumacher fullname: Schumacher, Fredrick R organization: Department of Medicine, Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Department of Epidemiology, Program in Molecular and Genetic Epidemiology, Harvard School of Public Health – sequence: 5 givenname: Sonja I surname: Berndt fullname: Berndt, Sonja I organization: Division of Cancer Epidemiology and Genetics, Department of Health and Human Services (DHHS), Occupational and Environmental Epidemiology Branch, National Cancer Institute (NCI), National Institutes of Health (NIH) – sequence: 6 givenname: Serena surname: Sanna fullname: Sanna, Serena organization: Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Istituto di Neurogenetica e Neurofarmacologia (INN), Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato – sequence: 7 givenname: Susana surname: Eyheramendy fullname: Eyheramendy, Susana organization: Institute of Epidemiology, GSF National Research Center for Environment and Health, Department of Epidemiology, Institute of Medical Informatics, Biometry and Epidemiology, University of Munich – sequence: 8 givenname: Benjamin F surname: Voight fullname: Voight, Benjamin F organization: Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Center for Human Genetic Research, Massachusetts General Hospital – sequence: 9 givenname: Johannah L surname: Butler fullname: Butler, Johannah L organization: Divisions of Genetics and Endocrinology and Program in Genomics, Children's Hospital – sequence: 10 givenname: Candace surname: Guiducci fullname: Guiducci, Candace organization: Program in Medical and Population Genetics, Broad Institute of MIT and Harvard – sequence: 11 givenname: Thomas surname: Illig fullname: Illig, Thomas organization: Institute of Epidemiology, GSF National Research Center for Environment and Health – sequence: 12 givenname: Rachel surname: Hackett fullname: Hackett, Rachel organization: Program in Medical and Population Genetics, Broad Institute of MIT and Harvard – sequence: 13 givenname: Iris M surname: Heid fullname: Heid, Iris M organization: Institute of Epidemiology, GSF National Research Center for Environment and Health, Department of Epidemiology, Institute of Medical Informatics, Biometry and Epidemiology, University of Munich – sequence: 14 givenname: Kevin B surname: Jacobs fullname: Jacobs, Kevin B organization: Bioinformed Consulting Services – sequence: 15 givenname: Valeriya surname: Lyssenko fullname: Lyssenko, Valeriya organization: Department of Clinical Sciences, Diabetes and Endocrinology, University Hospital Malmö, Lund University – sequence: 16 givenname: Manuela surname: Uda fullname: Uda, Manuela organization: Istituto di Neurogenetica e Neurofarmacologia (INN), Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato – sequence: 23 givenname: Michael surname: Boehnke fullname: Boehnke, Michael organization: Department of Biostatistics, Center for Statistical Genetics, University of Michigan – sequence: 24 givenname: Stephen J surname: Chanock fullname: Chanock, Stephen J organization: Division of Cancer Epidemiology and Genetics, Laboratory of Translational Genomics, NCI, NIH, DHHS – sequence: 25 givenname: Leif C surname: Groop fullname: Groop, Leif C organization: Department of Clinical Sciences, Diabetes and Endocrinology, University Hospital Malmö, Lund University, Department of Medicine, Helsinki University Central Hospital, and Research Program for Molecular Medicine, University of Helsinki – sequence: 26 givenname: Frank B surname: Hu fullname: Hu, Frank B organization: Department of Medicine, Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Department of Epidemiology, Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Department of Nutrition, Harvard School of Public Health – sequence: 27 givenname: Bo surname: Isomaa fullname: Isomaa, Bo organization: Malmska Municipal Health Center and Hospital, Folkhälsan Research Center – sequence: 28 givenname: Peter surname: Kraft fullname: Kraft, Peter organization: Department of Epidemiology, Program in Molecular and Genetic Epidemiology, Harvard School of Public Health – sequence: 29 givenname: Leena surname: Peltonen fullname: Peltonen, Leena organization: Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Wellcome Trust Sanger Institute, Department of Molecular Medicine, National Public Health Institute and Department of Medical Genetics, University of Helsinki – sequence: 30 givenname: Veikko surname: Salomaa fullname: Salomaa, Veikko organization: Department of Epidemiology and Health Promotion. National Public Health Institute – sequence: 31 givenname: David surname: Schlessinger fullname: Schlessinger, David organization: Gerontology Research Center, National Institute on Aging – sequence: 32 givenname: David J surname: Hunter fullname: Hunter, David J organization: Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Department of Medicine, Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Department of Epidemiology, Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Department of Nutrition, Harvard School of Public Health – sequence: 33 givenname: Richard B surname: Hayes fullname: Hayes, Richard B organization: Division of Cancer Epidemiology and Genetics, Department of Health and Human Services (DHHS), Occupational and Environmental Epidemiology Branch, National Cancer Institute (NCI), National Institutes of Health (NIH) – sequence: 34 givenname: Gonçalo R surname: Abecasis fullname: Abecasis, Gonçalo R organization: Department of Biostatistics, Center for Statistical Genetics, University of Michigan – sequence: 35 givenname: H-Erich surname: Wichmann fullname: Wichmann, H-Erich organization: Institute of Epidemiology, GSF National Research Center for Environment and Health, Department of Epidemiology, Institute of Medical Informatics, Biometry and Epidemiology, University of Munich – sequence: 36 givenname: Karen L surname: Mohlke fullname: Mohlke, Karen L organization: Department of Genetics, University of North Carolina – sequence: 37 givenname: Joel N surname: Hirschhorn fullname: Hirschhorn, Joel N email: joelh@broad.mit.edu organization: Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Divisions of Genetics and Endocrinology and Program in Genomics, Children's Hospital, Department of Genetics, Harvard Medical School |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20329975$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/18391950$$D View this record in MEDLINE/PubMed https://lup.lub.lu.se/record/1205108$$DView record from Swedish Publication Index oai:portal.research.lu.se:publications/ce9240ff-d437-4665-8a68-9402c329cdfd$$DView record from Swedish Publication Index |
| BookMark | eNqNk2uL1DAUhousuBf1J0hRVARnTNI0Tb4Iy-JlYWDB29eQyaXN0klmm9Rx_71nnHHWWRSX0iY0z3nPybkcFwchBlsUjzGaYlTxN6GdYlLfK45wTdkEN5gfwB4xPKGoYofFcUqXCGFKEX9QHGJeCSxqdFSYc2ND9s5rlX0MZXRltqHso_alSgkWla0pVz53ZWd92-Wyg2-_3qUy2FU597GPLdj35VLlbqWuU-lD2Y0LFcp2iKvcPSzuO9Un-2i7nhRf37_7cvZxMrv4cH52OpvopuF5wixrmprrZm6IcJRWrjGGCe4U54waYw2c0LlARChElNaKOIsprhsytwaT6qRQG920sstxLpeDX6jhWkbl5TIOWfVysMmqQXeyH2WyEqh-e_UktRWEIuekoVUjKWO15IpxKSgiuiJCG2fAx-yfPvpxCe98q31HubcbOdBaWKOhGAOEuRf53knwnWzjd0kYb1DDQODFVmCIV6NNWS580rbvVbBxTJIJXGMk_g8SBEUgzTqLT2-Bl3EcAhROEkIY5UJwgJ5toFb1VvrgIkSn14ryFHPGCYG6ADX9CwWPsQuvoYOdh_97Bq_2DIDJ9kdu1ZiSPP_86e7sxbd99smfad7l9_cgAPB8C6gErewGFbRPO44gKJho1kKvN5weYkqDdVL7_Kt_4Ga-lxjJ9TzK0EqYx5uk7_Cd59vgy21bARBaO9wk_Rb5E9bMQL4 |
| CODEN | NGENEC |
| CitedBy_id | crossref_primary_10_1038_ng_383 crossref_primary_10_1038_ng_386 crossref_primary_10_1002_mrd_23347 crossref_primary_10_3390_genes14101839 crossref_primary_10_1038_ng_382 crossref_primary_10_1007_s00439_018_1902_3 crossref_primary_10_1038_jhg_2012_43 crossref_primary_10_1016_j_beem_2010_10_013 crossref_primary_10_1016_j_mehy_2011_01_019 crossref_primary_10_1371_journal_pgen_1002383 crossref_primary_10_3168_jds_2009_2980 crossref_primary_10_1093_hmg_ddy121 crossref_primary_10_1038_nsmb_1676 crossref_primary_10_3724_SP_J_1005_2011_01308 crossref_primary_10_1371_journal_pone_0169860 crossref_primary_10_4238_2012_June_15_6 crossref_primary_10_1101_gr_192971_115 crossref_primary_10_1093_hmg_ddq510 crossref_primary_10_1016_S0140_6736_08_60600_5 crossref_primary_10_3389_fgene_2021_645107 crossref_primary_10_1136_ard_2009_120170 crossref_primary_10_1016_j_ehb_2009_09_005 crossref_primary_10_1534_genetics_108_099218 crossref_primary_10_1093_hmg_ddp423 crossref_primary_10_1093_hmg_ddn246 crossref_primary_10_7554_eLife_53608 crossref_primary_10_1186_s12863_016_0368_3 crossref_primary_10_1016_j_plantsci_2012_08_004 crossref_primary_10_1038_ng_121 crossref_primary_10_1210_en_2012_2006 crossref_primary_10_1371_journal_pgen_1001035 crossref_primary_10_1371_journal_pgen_1003211 crossref_primary_10_1371_journal_pgen_1003694 crossref_primary_10_1371_journal_pgen_1001273 crossref_primary_10_4137_EBO_S10211 crossref_primary_10_1038_ng_2639 crossref_primary_10_1093_ije_dyq260 crossref_primary_10_3390_biom10010005 crossref_primary_10_1016_j_euroecorev_2012_09_009 crossref_primary_10_1186_s40246_015_0041_3 crossref_primary_10_1016_j_tem_2015_12_006 crossref_primary_10_1101_gr_157339_113 crossref_primary_10_1016_j_ajhg_2009_01_013 crossref_primary_10_1016_j_ajhg_2010_11_007 crossref_primary_10_1038_ng_593 crossref_primary_10_1016_j_ajhg_2009_01_005 crossref_primary_10_3390_ani9060296 crossref_primary_10_1093_aje_kwu126 crossref_primary_10_1146_annurev_genet_022123_110824 crossref_primary_10_1016_j_aquaculture_2022_738710 crossref_primary_10_1016_S1245_1789_16_80712_X crossref_primary_10_1038_s41467_023_42345_9 crossref_primary_10_1101_gr_087577_108 crossref_primary_10_1016_j_ygeno_2014_11_009 crossref_primary_10_1186_1297_9686_42_9 crossref_primary_10_1111_j_1469_1809_2010_00597_x crossref_primary_10_1242_dev_089797 crossref_primary_10_1038_ng_357 crossref_primary_10_1038_nature07631 crossref_primary_10_1016_j_cell_2012_02_005 crossref_primary_10_1080_03014460_2023_2215546 crossref_primary_10_3390_ijms21186665 crossref_primary_10_1007_s10528_010_9406_4 crossref_primary_10_1097_MOP_0b013e3283300b10 crossref_primary_10_1152_japplphysiol_91123_2008 crossref_primary_10_1002_stem_1423 crossref_primary_10_1371_journal_pone_0078530 crossref_primary_10_1590_1678_4685_gmb_2016_0017 crossref_primary_10_1097_EDE_0b013e318181b865 crossref_primary_10_1007_s00439_011_1096_4 crossref_primary_10_1016_j_bbamcr_2017_12_003 crossref_primary_10_1371_journal_pone_0004464 crossref_primary_10_1038_nature07862 crossref_primary_10_1093_ije_dyq203 crossref_primary_10_1007_s00586_019_06001_5 crossref_primary_10_1016_j_cbi_2016_10_019 crossref_primary_10_1038_ncomms8500 crossref_primary_10_1515_jpem_2010_181 crossref_primary_10_1002_elps_201100128 crossref_primary_10_1016_j_ajhg_2021_02_011 crossref_primary_10_1016_j_jtbi_2009_07_020 crossref_primary_10_3390_genes13010121 crossref_primary_10_1016_j_earlhumdev_2014_06_012 crossref_primary_10_1093_hmg_ddn350 crossref_primary_10_5665_sleep_4082 crossref_primary_10_3390_epigenomes3010007 crossref_primary_10_1534_g3_115_017772 crossref_primary_10_1002_ajpa_21512 crossref_primary_10_1093_nar_gkq428 crossref_primary_10_1093_aje_kwu039 crossref_primary_10_1002_gcc_20869 crossref_primary_10_1371_journal_pone_0144977 crossref_primary_10_1186_s12711_015_0127_3 crossref_primary_10_1007_s00439_009_0686_x crossref_primary_10_1007_s11033_010_0063_9 crossref_primary_10_1089_gtmb_2009_0072 crossref_primary_10_2527_jas_2016_1137 crossref_primary_10_1371_journal_pgen_1005433 crossref_primary_10_1016_j_tcb_2012_06_001 crossref_primary_10_1016_j_cub_2009_11_055 crossref_primary_10_1016_j_ajhg_2009_09_017 crossref_primary_10_1146_annurev_neuro_051508_135335 crossref_primary_10_1158_0008_5472_CAN_10_4167 crossref_primary_10_1097_MED_0b013e328331dca2 crossref_primary_10_1038_ng_3911 crossref_primary_10_1164_rccm_201302_0263OC crossref_primary_10_1161_CIRCGENETICS_108_817064 crossref_primary_10_1073_pnas_1419064111 crossref_primary_10_1038_ng_311 crossref_primary_10_1186_s12863_024_01252_8 crossref_primary_10_1210_er_2013_1067 crossref_primary_10_1016_j_metabol_2012_03_018 crossref_primary_10_1371_journal_pgen_1000365 crossref_primary_10_1016_j_ajhg_2010_02_017 crossref_primary_10_1534_genetics_108_092643 crossref_primary_10_1111_jcmm_13210 crossref_primary_10_3389_fgene_2020_587243 crossref_primary_10_1007_s00439_011_0969_x crossref_primary_10_1038_s41525_025_00468_6 crossref_primary_10_1261_rna_045542_114 crossref_primary_10_1038_ng_663 crossref_primary_10_1017_S0016672310000571 crossref_primary_10_1016_j_csbj_2020_06_011 crossref_primary_10_1093_aje_kww128 crossref_primary_10_1138_20080324 crossref_primary_10_1111_j_1365_3016_2012_01310_x crossref_primary_10_1016_j_jmb_2013_03_007 crossref_primary_10_1101_gr_118992_110 crossref_primary_10_1016_j_mce_2010_01_038 crossref_primary_10_1007_s12024_022_00545_7 crossref_primary_10_2217_nnm_10_160 crossref_primary_10_1111_age_13112 crossref_primary_10_1016_S2213_8587_15_00474_X crossref_primary_10_2217_pme_11_27 crossref_primary_10_1515_sh_2016_0007 crossref_primary_10_1093_hmg_ddn405 crossref_primary_10_1097_MED_0b013e328320253c crossref_primary_10_1139_gen_2018_0006 crossref_primary_10_1016_j_ando_2017_04_004 crossref_primary_10_1074_jbc_M110_169607 crossref_primary_10_1016_S1673_8527_09_60095_3 crossref_primary_10_1038_mp_2008_113 crossref_primary_10_3109_07853890_2010_515603 crossref_primary_10_3109_07853890_2011_573803 crossref_primary_10_1146_annurev_pharmtox_011112_140241 crossref_primary_10_1038_jhg_2009_116 crossref_primary_10_1007_s00439_019_02034_4 crossref_primary_10_1101_gr_095224_109 crossref_primary_10_1186_s12863_014_0117_4 crossref_primary_10_1111_evo_12775 crossref_primary_10_1111_j_1365_294X_2009_04518_x crossref_primary_10_1111_j_1365_2265_2012_04410_x crossref_primary_10_1002_ajmg_a_34397 crossref_primary_10_1016_j_ajhg_2022_12_002 crossref_primary_10_1371_journal_pone_0024220 crossref_primary_10_1007_s10519_012_9533_2 crossref_primary_10_1038_aja_2011_75 crossref_primary_10_1093_jnci_djv219 crossref_primary_10_1146_annurev_publhealth_012809_103639 crossref_primary_10_1007_s12015_009_9095_8 crossref_primary_10_1093_hmg_ddu361 crossref_primary_10_1007_s00467_012_2301_y crossref_primary_10_1016_j_mce_2012_05_003 crossref_primary_10_1210_jc_2008_0882 crossref_primary_10_1007_s13205_020_02434_8 crossref_primary_10_1016_j_legalmed_2012_02_001 crossref_primary_10_1016_j_ajhg_2009_03_007 crossref_primary_10_1016_j_exer_2009_02_008 crossref_primary_10_1038_ng_500 crossref_primary_10_1159_000496989 crossref_primary_10_1038_srep44793 crossref_primary_10_1371_journal_pone_0119606 crossref_primary_10_1016_j_gdata_2014_04_004 crossref_primary_10_1080_02640410903114364 crossref_primary_10_1242_jeb_216499 crossref_primary_10_1126_science_1182009 crossref_primary_10_1134_S2079059714020038 crossref_primary_10_1038_nrg2554 crossref_primary_10_1038_nature09410 crossref_primary_10_1186_s12862_023_02171_5 crossref_primary_10_3390_ani14162407 crossref_primary_10_1016_j_ajhg_2010_03_010 crossref_primary_10_1038_ng_610 crossref_primary_10_1375_twin_13_6_517 crossref_primary_10_1038_mp_2011_41 crossref_primary_10_1093_hmg_ddaf015 crossref_primary_10_1111_jopy_12186 crossref_primary_10_6065_apem_2346238_119 crossref_primary_10_1056_NEJMoa0900158 crossref_primary_10_1007_s00439_013_1394_0 crossref_primary_10_1016_j_psc_2009_10_005 crossref_primary_10_1038_ng_608 crossref_primary_10_1016_j_jhep_2009_12_025 crossref_primary_10_1038_nri2361 crossref_primary_10_1038_nrrheum_2013_121 crossref_primary_10_1016_j_plrev_2015_02_007 crossref_primary_10_1186_s12967_017_1273_x crossref_primary_10_1007_s10059_010_0129_5 crossref_primary_10_1371_journal_pgen_1002316 crossref_primary_10_1007_s11892_015_0610_9 crossref_primary_10_1097_MOP_0b013e32832c6dce crossref_primary_10_1038_nrendo_2012_251 crossref_primary_10_3390_ijms140816532 crossref_primary_10_1182_blood_2008_10_184234 crossref_primary_10_1111_j_1469_1809_2010_00606_x crossref_primary_10_1017_S1751731110002120 crossref_primary_10_1038_nature07331 crossref_primary_10_1016_j_ymgmr_2024_101086 crossref_primary_10_1038_s41539_017_0005_6 crossref_primary_10_1016_j_livsci_2013_05_022 crossref_primary_10_1093_bioinformatics_btq560 crossref_primary_10_1074_jbc_RA119_010835 crossref_primary_10_1038_msb_2010_1 crossref_primary_10_1258_jrsm_2009_09k077 crossref_primary_10_1530_EJE_08_0794 crossref_primary_10_1056_NEJMp0804318 crossref_primary_10_1016_j_gde_2010_05_005 crossref_primary_10_1016_j_annepidem_2013_11_008 crossref_primary_10_1111_j_1540_5834_2011_00629_x crossref_primary_10_1073_pnas_0804799105 crossref_primary_10_1371_journal_pgen_1000409 crossref_primary_10_1159_000437324 crossref_primary_10_1002_ajmg_a_37117 crossref_primary_10_1203_PDR_0b013e31818d0f6c crossref_primary_10_1016_j_jaci_2013_06_018 crossref_primary_10_1186_1471_2350_11_96 crossref_primary_10_1210_jc_2010_1131 crossref_primary_10_1210_jc_2009_0392 crossref_primary_10_1101_gr_107920_110 crossref_primary_10_1371_journal_pone_0175971 crossref_primary_10_1073_pnas_0906182107 crossref_primary_10_1007_s00018_013_1313_5 crossref_primary_10_1371_journal_pone_0039929 crossref_primary_10_1038_s41598_021_99225_9 crossref_primary_10_1073_pnas_1402875111 crossref_primary_10_1155_2018_4868045 crossref_primary_10_1586_egh_09_45 crossref_primary_10_1016_j_mgene_2018_06_004 crossref_primary_10_1038_ng_814 crossref_primary_10_1186_1687_9856_2013_19 crossref_primary_10_1073_pnas_0810388105 crossref_primary_10_1534_genetics_110_123943 crossref_primary_10_1016_j_cell_2013_09_059 crossref_primary_10_1002_gepi_20580 crossref_primary_10_1093_jnci_djy132 crossref_primary_10_1371_journal_pone_0056497 crossref_primary_10_1210_jendso_bvac006 crossref_primary_10_1038_456018a crossref_primary_10_1101_gad_1693608 crossref_primary_10_1146_annurev_med_60_103007_132540 crossref_primary_10_1136_annrheumdis_2012_202081 crossref_primary_10_1093_hmg_ddu583 crossref_primary_10_1371_journal_pone_0156086 crossref_primary_10_1016_j_beem_2010_06_007 crossref_primary_10_1371_journal_pone_0193196 crossref_primary_10_1146_annurev_genom_9_081307_164350 crossref_primary_10_1111_asj_12417 crossref_primary_10_1111_imr_12048 crossref_primary_10_1111_papr_12648 crossref_primary_10_1002_per_836 crossref_primary_10_1371_journal_pgen_1000508 crossref_primary_10_1007_s00223_009_9307_x crossref_primary_10_1186_s12929_019_0581_2 crossref_primary_10_1038_srep04678 crossref_primary_10_1002_gepi_20449 crossref_primary_10_1093_hmg_ddq091 crossref_primary_10_1146_annurev_genom_9_081307_164242 crossref_primary_10_3390_ani10091472 crossref_primary_10_1186_1471_2164_14_798 crossref_primary_10_1375_twin_13_2_179 crossref_primary_10_1530_EJE_08_0647 crossref_primary_10_1186_1753_6561_3_S7_S19 crossref_primary_10_1210_jc_2009_2344 crossref_primary_10_1186_1471_2156_12_64 crossref_primary_10_1016_j_bbcan_2013_02_002 crossref_primary_10_1016_j_gene_2012_10_026 crossref_primary_10_1371_journal_pgen_1000445 crossref_primary_10_1093_biostatistics_kxt041 crossref_primary_10_1016_j_ejmg_2009_03_001 crossref_primary_10_1101_gr_275560_121 crossref_primary_10_1038_srep15683 crossref_primary_10_1371_journal_pone_0106924 crossref_primary_10_1111_j_1469_1809_2008_00484_x crossref_primary_10_1371_journal_pone_0063821 crossref_primary_10_1007_s11033_011_0894_z crossref_primary_10_1371_journal_pone_0173997 crossref_primary_10_1186_1297_9686_42_37 crossref_primary_10_1093_bioinformatics_btr219 crossref_primary_10_1093_molbev_msn214 crossref_primary_10_1371_journal_pgen_1000678 crossref_primary_10_1093_hmg_ddq154 crossref_primary_10_3390_ani11072064 crossref_primary_10_1093_hmg_ddr489 crossref_primary_10_1111_j_1469_185X_2009_00096_x crossref_primary_10_1186_1471_2156_13_40 crossref_primary_10_1038_s41576_019_0127_1 crossref_primary_10_1210_jc_2012_4283 crossref_primary_10_1016_j_cub_2013_02_040 crossref_primary_10_1210_clinem_dgaa131 crossref_primary_10_1375_twin_11_5_488 crossref_primary_10_1210_er_2009_0039 crossref_primary_10_3390_ijms25052506 crossref_primary_10_1017_S0016672311000310 crossref_primary_10_1038_s41598_017_16070_5 crossref_primary_10_1002_gepi_20377 crossref_primary_10_1016_j_ydbio_2011_01_016 crossref_primary_10_1097_MED_0b013e3283339a46 crossref_primary_10_1016_j_ajhg_2010_06_009 crossref_primary_10_1073_pnas_1118922109 crossref_primary_10_1152_physiolgenomics_00005_2015 crossref_primary_10_1007_s00439_008_0568_7 crossref_primary_10_1530_JOE_15_0360 crossref_primary_10_1371_journal_pgen_1000534 crossref_primary_10_1038_oby_2010_256 crossref_primary_10_1111_jvim_15403 crossref_primary_10_1007_s00439_013_1280_9 crossref_primary_10_1056_NEJMoa0904006 crossref_primary_10_1093_humrep_det071 crossref_primary_10_1016_j_gene_2018_04_027 crossref_primary_10_1177_0962280219839093 crossref_primary_10_5187_jast_2020_62_3_293 crossref_primary_10_1007_s00439_008_0512_x crossref_primary_10_1016_j_fsigen_2009_01_012 crossref_primary_10_1182_blood_2012_12_472308 crossref_primary_10_15302_J_QB_021_0249 crossref_primary_10_1186_gb_2012_13_4_244 crossref_primary_10_1371_journal_pone_0112322 crossref_primary_10_1016_j_tips_2010_04_002 crossref_primary_10_1007_s00439_008_0621_6 crossref_primary_10_1146_annurev_genom_091212_153520 crossref_primary_10_1038_hdy_2010_11 crossref_primary_10_1080_15427609_2011_625321 crossref_primary_10_1111_asj_12033 crossref_primary_10_1038_ijos_2015_14 crossref_primary_10_1093_hmg_ddp382 crossref_primary_10_1038_jhg_2010_33 crossref_primary_10_1038_nrc2587 crossref_primary_10_1214_09_STS290 crossref_primary_10_1016_j_tig_2008_09_006 crossref_primary_10_1186_1471_2156_14_52 crossref_primary_10_1002_cam4_279 crossref_primary_10_1016_j_ajhg_2013_12_016 crossref_primary_10_3390_ijms23137245 crossref_primary_10_1016_j_jflm_2022_102351 crossref_primary_10_1016_j_ghir_2011_08_001 crossref_primary_10_1007_s00266_011_9680_5 crossref_primary_10_1038_ejhg_2009_5 crossref_primary_10_1007_s00774_015_0697_8 crossref_primary_10_4051_ibc_2014_6_1_0001 crossref_primary_10_1016_j_jas_2015_02_033 crossref_primary_10_1093_hmg_ddp296 crossref_primary_10_1038_jhg_2010_44 crossref_primary_10_1093_hmg_dds323 crossref_primary_10_1111_j_1469_1809_2009_00555_x crossref_primary_10_1038_ejcn_2009_124 crossref_primary_10_1534_genetics_111_131698 crossref_primary_10_1016_j_yfrne_2018_11_001 crossref_primary_10_1038_ng0508_489 crossref_primary_10_1038_oby_2010_349 crossref_primary_10_1093_nar_gkt1391 crossref_primary_10_1016_j_peptides_2011_09_006 crossref_primary_10_1016_j_stem_2016_05_016 crossref_primary_10_1093_bioinformatics_btr024 crossref_primary_10_1111_nyas_12397 crossref_primary_10_1111_j_1398_9995_2010_02415_x crossref_primary_10_1093_aobpla_plu004 crossref_primary_10_1186_s12711_020_00571_5 crossref_primary_10_1371_journal_pone_0144155 crossref_primary_10_1210_jc_2008_2010 crossref_primary_10_1373_clinchem_2008_107243 crossref_primary_10_1126_science_1156409 crossref_primary_10_1038_s41598_022_24529_3 crossref_primary_10_1002_gepi_20552 crossref_primary_10_3835_plantgenome2010_12_0029 crossref_primary_10_1016_j_cell_2010_02_007 crossref_primary_10_1186_1753_6561_3_S7_S107 crossref_primary_10_1525_bio_2010_60_1_6 crossref_primary_10_1530_EJE_11_0478 crossref_primary_10_1093_bioinformatics_btq088 crossref_primary_10_1371_journal_pone_0029475 crossref_primary_10_1016_j_isci_2020_101850 crossref_primary_10_1038_s41598_021_90155_0 crossref_primary_10_1038_s41598_017_06766_z crossref_primary_10_1074_jbc_M111_321158 crossref_primary_10_1002_gepi_20424 crossref_primary_10_1007_s11033_009_9604_5 crossref_primary_10_1016_j_jpsychores_2009_06_006 crossref_primary_10_1186_1471_2164_14_382 crossref_primary_10_1097_MOP_0000000000000235 crossref_primary_10_1016_j_mce_2018_09_001 crossref_primary_10_1103_PhysRevE_108_064404 crossref_primary_10_1111_j_1365_294X_2012_05757_x crossref_primary_10_1093_hmg_ddn288 crossref_primary_10_1016_j_neuron_2010_10_002 crossref_primary_10_1038_jhh_2008_134 crossref_primary_10_1093_hmg_ddn289 crossref_primary_10_1097_BOR_0b013e328336474d crossref_primary_10_1007_s00439_008_0590_9 crossref_primary_10_1210_jc_2009_1715 crossref_primary_10_1038_jhg_2009_99 crossref_primary_10_1002_sim_8141 crossref_primary_10_1016_j_jpp_2018_01_003 crossref_primary_10_1186_1471_2156_15_34 crossref_primary_10_1038_ng_287 crossref_primary_10_1002_gepi_20533 crossref_primary_10_1016_j_coi_2009_06_003 crossref_primary_10_1186_s13059_021_02353_8 crossref_primary_10_5924_abgri_41_15 crossref_primary_10_3389_fcell_2023_1215406 crossref_primary_10_1111_jth_13719 crossref_primary_10_1172_jci_insight_169425 crossref_primary_10_1016_j_neuropharm_2013_05_004 crossref_primary_10_1186_s12916_022_02450_w crossref_primary_10_1111_cen_12145 crossref_primary_10_3390_ani14050687 crossref_primary_10_1016_j_cell_2011_10_020 crossref_primary_10_2527_jas_2015_9838 crossref_primary_10_1007_s11914_019_00527_9 crossref_primary_10_1159_000504669 crossref_primary_10_1371_journal_pgen_1008780 crossref_primary_10_1534_g3_119_400812 crossref_primary_10_1038_ncomms9658 crossref_primary_10_3390_ani14050792 crossref_primary_10_14814_phy2_12047 crossref_primary_10_1146_annurev_cellbio_100913_012927 crossref_primary_10_1038_pr_2015_225 crossref_primary_10_1007_s10539_021_09823_0 crossref_primary_10_17816_ecogen10477_84 crossref_primary_10_1073_pnas_0906195106 crossref_primary_10_1155_2019_4678969 crossref_primary_10_1016_j_ygeno_2012_11_002 crossref_primary_10_1093_hmg_ddr309 crossref_primary_10_1007_s00438_015_1017_7 |
| Cites_doi | 10.1186/1471-2156-4-S1-S36 10.1101/gad.1540407 10.1158/0008-5472.CAN-07-1083 10.1038/17611 10.1126/science.1141634 10.1101/gad.1224204 10.1038/ng2075 10.1126/science.274.5295.2082 10.1038/nrg1521 10.1371/journal.pgen.0030097 10.1093/ije/29.1.49 10.1371/journal.pgen.0030115 10.1086/512821 10.1038/ng1071 10.1086/321287 10.1038/ng2121 10.1086/521580 10.1093/oxfordjournals.epirev.a000809 10.1038/ng1847 10.1038/ng1536 10.1038/ng.74 10.1126/science.1137999 10.1093/bioinformatics/19.1.149 10.1371/journal.pgen.0030236 10.1055/s-2005-858226 10.1002/gcc.20346 10.1016/j.gene.2006.07.011 10.1371/journal.pgen.0020132 10.1017/S0080456800012163 10.1038/ng1607 10.1126/science.1142358 10.1126/science.1142382 10.1086/519795 10.1038/ng2022 10.1136/bmj.327.7414.557 10.1101/gad.13.16.2072 10.1126/science.1133427 10.1038/nature04226 10.1038/nature05911 10.1038/ng.121 |
| ContentType | Journal Article |
| Copyright | Springer Nature America, Inc. 2008 2008 INIST-CNRS COPYRIGHT 2008 Nature Publishing Group Copyright Nature Publishing Group May 2008 |
| Copyright_xml | – notice: Springer Nature America, Inc. 2008 – notice: 2008 INIST-CNRS – notice: COPYRIGHT 2008 Nature Publishing Group – notice: Copyright Nature Publishing Group May 2008 |
| CorporateAuthor | KORA The Diabetes Genetics Initiative FUSION SardiNIA The Prostate, Lung Colorectal and Ovarian Cancer Screening Trial The Nurses' Health Study Diabetes Genetics Initiative Nurses' Health Study Prostate, Lung Colorectal and Ovarian Cancer Screening Trial Translationell muskelforskning Faculty of Medicine Lunds universitet Translational Muscle Research Department of Clinical Sciences, Malmö Medicinska fakulteten Lund University Institutionen för kliniska vetenskaper, Malmö |
| CorporateAuthor_xml | – name: SardiNIA – name: FUSION – name: The Nurses' Health Study – name: KORA – name: The Diabetes Genetics Initiative – name: The Prostate, Lung Colorectal and Ovarian Cancer Screening Trial – name: Prostate, Lung Colorectal and Ovarian Cancer Screening Trial – name: Diabetes Genetics Initiative – name: Nurses' Health Study – name: Faculty of Medicine – name: Translational Muscle Research – name: Medicinska fakulteten – name: Translationell muskelforskning – name: Lund University – name: Institutionen för kliniska vetenskaper, Malmö – name: Lunds universitet – name: Department of Clinical Sciences, Malmö |
| DBID | AAYXX CITATION IQODW CGR CUY CVF ECM EIF NPM IOV ISR 3V. 7QL 7QP 7QR 7SS 7T7 7TK 7TM 7U9 7X7 7XB 88A 88E 8AO 8C1 8FD 8FE 8FH 8FI 8FJ 8FK 8G5 ABUWG AEUYN AFKRA AZQEC BBNVY BENPR BHPHI C1K CCPQU DWQXO FR3 FYUFA GHDGH GNUQQ GUQSH H94 HCIFZ K9. LK8 M0S M1P M2O M7N M7P MBDVC P64 PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS Q9U RC3 7X8 5PM ADTPV AOWAS D95 |
| DOI | 10.1038/ng.125 |
| DatabaseName | CrossRef Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed In Context: Opposing Viewpoints Gale In Context: Science ProQuest Central (Corporate) Bacteriology Abstracts (Microbiology B) Calcium & Calcified Tissue Abstracts Chemoreception Abstracts Entomology Abstracts (Full archive) Industrial and Applied Microbiology Abstracts (Microbiology A) Neurosciences Abstracts Nucleic Acids Abstracts Virology and AIDS Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Biology Database (Alumni Edition) Medical Database (Alumni Edition) ProQuest Pharma Collection Public Health Database Technology Research Database ProQuest SciTech Collection ProQuest Natural Science Collection ProQuest Hospital Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Research Library ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland ProQuest Central Essentials Biological Science Collection ProQuest Central Natural Science Collection Environmental Sciences and Pollution Management ProQuest One ProQuest Central Korea Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student ProQuest Research Library AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Biological Sciences ProQuest Health & Medical Collection Medical Database Research Library (Proquest) Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Research Library (Corporate) Biotechnology and BioEngineering Abstracts ProQuest Central Premium ProQuest One Academic ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China ProQuest Central Basic Genetics Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) SwePub SwePub Articles SWEPUB Lunds universitet |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Research Library Prep ProQuest Central Student ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection ProQuest Central China Environmental Sciences and Pollution Management ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Natural Science Collection Health & Medical Research Collection Biological Science Collection Chemoreception Abstracts Industrial and Applied Microbiology Abstracts (Microbiology A) ProQuest Central (New) ProQuest Medical Library (Alumni) Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database Neurosciences Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Entomology Abstracts ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Engineering Research Database ProQuest One Academic Calcium & Calcified Tissue Abstracts ProQuest One Academic (New) Technology Research Database ProQuest One Academic Middle East (New) ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing Research Library (Alumni Edition) ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Biology Journals (Alumni Edition) ProQuest Central ProQuest Health & Medical Research Collection Genetics Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) AIDS and Cancer Research Abstracts ProQuest Research Library ProQuest Public Health ProQuest Central Basic ProQuest SciTech Collection ProQuest Medical Library ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | Genetics Abstracts MEDLINE Research Library Prep MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 3 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Agriculture Biology |
| EISSN | 1546-1718 |
| EndPage | 591 |
| ExternalDocumentID | oai_portal_research_lu_se_publications_ce9240ff_d437_4665_8a68_9402c329cdfd oai_lup_lub_lu_se_ce9240ff_d437_4665_8a68_9402c329cdfd PMC2687076 1480252511 A186822415 18391950 20329975 10_1038_ng_125 |
| Genre | Meta-Analysis Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural |
| GeographicLocations | United States |
| GeographicLocations_xml | – name: United States |
| GrantInformation_xml | – fundername: NHLBI NIH HHS grantid: HL084729 – fundername: NIDDK NIH HHS grantid: R01 DK062370 – fundername: NIDDK NIH HHS grantid: R01 DK072193 – fundername: NHGRI NIH HHS grantid: R01 HG002651 – fundername: NCI NIH HHS grantid: P01 CA087969 – fundername: NCI NIH HHS grantid: U01 CA049449 – fundername: NIDDK NIH HHS grantid: R01 DK075787 – fundername: NIDDK NIH HHS grantid: U01 DK062370 – fundername: NHGRI NIH HHS grantid: HG02651 – fundername: Intramural NIH HHS – fundername: Wellcome Trust : grantid: 089061 || WT |
| GroupedDBID | --- -DZ -~X .55 .GJ 0R~ 123 29M 2FS 36B 39C 3O- 3V. 4.4 53G 5BI 5M7 5RE 5S5 70F 7X7 85S 88A 88E 8AO 8C1 8FE 8FH 8FI 8FJ 8G5 8R4 8R5 AAEEF AAHBH AARCD AAYOK AAYZH AAZLF ABAWZ ABCQX ABDBF ABDPE ABEFU ABJNI ABLJU ABOCM ABTAH ABUWG ACBWK ACGFO ACGFS ACIWK ACMJI ACNCT ACPRK ACUHS ADBBV ADFRT AENEX AEUYN AFBBN AFFNX AFKRA AFRAH AFSHS AGAYW AGCDD AGHTU AHBCP AHMBA AHOSX AHSBF AIBTJ ALFFA ALIPV ALMA_UNASSIGNED_HOLDINGS AMTXH ARMCB ASPBG AVWKF AXYYD AZFZN AZQEC B0M BBNVY BENPR BHPHI BKKNO BPHCQ BVXVI CCPQU CS3 DB5 DU5 DWQXO EAD EAP EBC EBD EBS EE. EJD EMB EMK EMOBN EPL ESX EXGXG F5P FEDTE FQGFK FSGXE FYUFA GNUQQ GUQSH GX1 HCIFZ HMCUK HVGLF HZ~ IAO IH2 IHR INH INR IOV ISR ITC L7B LGEZI LK8 LOTEE M0L M1P M2O M7P MVM N9A NADUK NNMJJ NXXTH ODYON P2P PKN PQQKQ PROAC PSQYO Q2X RIG RNS RNT RNTTT RVV SHXYY SIXXV SJN SNYQT SOJ SV3 TAOOD TBHMF TDRGL TN5 TSG TUS UKHRP VQA X7M XJT XOL Y6R YHZ ZGI ZXP ZY4 ~8M ~KM AAYXX ABFSG ACMFV ACSTC AETEA AFANA ALPWD ATHPR CITATION PHGZM PHGZT AEZWR AFHIU AHWEU AIXLP IQODW NFIDA PJZUB PPXIY PQGLB CGR CUY CVF ECM EIF NPM PMFND AEIIB 7QL 7QP 7QR 7SS 7T7 7TK 7TM 7U9 7XB 8FD 8FK C1K FR3 H94 K9. M7N MBDVC P64 PKEHL PQEST PQUKI PRINS Q9U RC3 7X8 5PM ADTPV AOWAS D95 PUEGO |
| ID | FETCH-LOGICAL-c778t-6e67758c7bd29f443f7dd698fa8864dded7bd4b9029a02acca2fe141572bed123 |
| IEDL.DBID | 7X7 |
| ISSN | 1061-4036 1546-1718 |
| IngestDate | Sat Aug 30 03:21:04 EDT 2025 Thu Jul 03 05:21:00 EDT 2025 Thu Aug 21 18:30:02 EDT 2025 Thu Jul 10 17:13:21 EDT 2025 Thu Jul 10 18:47:30 EDT 2025 Sat Aug 23 12:31:15 EDT 2025 Tue Jun 17 22:19:47 EDT 2025 Tue Jun 10 21:21:08 EDT 2025 Fri Jun 27 06:11:43 EDT 2025 Fri Jun 27 06:07:50 EDT 2025 Fri May 30 11:01:33 EDT 2025 Mon Jul 21 09:12:10 EDT 2025 Thu Apr 24 22:58:53 EDT 2025 Tue Jul 01 01:50:07 EDT 2025 Fri Feb 21 02:37:42 EST 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 5 |
| Keywords | Human Identification Locus Growth |
| Language | English |
| License | http://www.springer.com/tdm CC BY 4.0 |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c778t-6e67758c7bd29f443f7dd698fa8864dded7bd4b9029a02acca2fe141572bed123 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Article-2 ObjectType-Feature-1 content type line 23 These authors contributed equally to this work. G.L., A.U.J., C. Gieger., F.R.S., S.I.B., S.S., S.E. and B.F.V. performed analyses. G.L. performed the meta-analysis and selected markers for follow-up. J.L.B., C. Guiducci, T.I. and R.H. genotyped markers in some of the follow-up panels. G.L. and J.N.H. wrote the manuscript, with inputs from the other authors, especially M.B. and S.I.B. V.L., L.C.G., B.I. and J.N.H. are investigators of the DGI and Botnia studies. L.P. and V.S. are investigators of the FINRISK97 study. M.U., D.S. and G.R.A. are investigators of the SardiNIA study. K.B.J., S.J.C. and R.B.H. are investigators of the PLCO study. I.M.H. and H.-E.W. are investigators of the KORA study. M.B. and K.L.M. are investigators of the FUSION study. F.B.H., P.K. and D.J.H. are investigators of the NHS. D.J.H, R.B.H., G.R.A., H.-E.W., K.L.M. and J.N.H. led this study. All authors read and approved the final manuscript. A full list of authors and affiliations appears in the Supplementary Note online AUTHOR CONTRIBUTIONS |
| OpenAccessLink | http://doi.org/10.1038/ng.125 |
| PMID | 18391950 |
| PQID | 222648998 |
| PQPubID | 33429 |
| PageCount | 8 |
| ParticipantIDs | swepub_primary_oai_portal_research_lu_se_publications_ce9240ff_d437_4665_8a68_9402c329cdfd swepub_primary_oai_lup_lub_lu_se_ce9240ff_d437_4665_8a68_9402c329cdfd pubmedcentral_primary_oai_pubmedcentral_nih_gov_2687076 proquest_miscellaneous_69151096 proquest_miscellaneous_20778272 proquest_journals_222648998 gale_infotracmisc_A186822415 gale_infotracacademiconefile_A186822415 gale_incontextgauss_ISR_A186822415 gale_incontextgauss_IOV_A186822415 pubmed_primary_18391950 pascalfrancis_primary_20329975 crossref_citationtrail_10_1038_ng_125 crossref_primary_10_1038_ng_125 springer_journals_10_1038_ng_125 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2008-05-01 |
| PublicationDateYYYYMMDD | 2008-05-01 |
| PublicationDate_xml | – month: 05 year: 2008 text: 2008-05-01 day: 01 |
| PublicationDecade | 2000 |
| PublicationPlace | New York |
| PublicationPlace_xml | – name: New York – name: London – name: United States |
| PublicationTitle | Nature genetics |
| PublicationTitleAbbrev | Nat Genet |
| PublicationTitleAlternate | Nat Genet |
| PublicationYear | 2008 |
| Publisher | Nature Publishing Group US Nature Publishing Group |
| Publisher_xml | – name: Nature Publishing Group US – name: Nature Publishing Group |
| References | Hirschhorn (CR33) 2001; 69 St-Jacques, Hammerschmidt, McMahon (CR23) 1999; 13 Lohmueller, Pearce, Pike, Lander, Hirschhorn (CR34) 2003; 33 Guo (CR28) 2006; 384 Zollner, Pritchard (CR35) 2007; 80 CR18 Chikuda (CR30) 2004; 18 Higgins, Thompson, Deeks, Altman (CR40) 2003; 327 Asp, Persson, Kost-Alimova, Stenman (CR32) 2006; 45 Campbell (CR19) 2005; 37 Lee, Dutta (CR25) 2007; 21 Scott (CR13) 2007; 316 Pilia (CR17) 2006; 2 Chuang, McMahon (CR22) 1999; 397 Pfeifer (CR29) 1996; 274 Mathias (CR9) 2003; 4 Price (CR20) 2006; 38 Hirschhorn, Daly (CR1) 2005; 6 Saxena (CR4) 2007; 316 Frayling (CR5) 2007; 316 Purcell, Cherny, Sham (CR36) 2003; 19 Gunnell (CR10) 2001; 23 CR2 Sanna (CR11) 2008; 40 CR3 Johnson (CR26) 2007; 67 Scuteri (CR6) 2007; 3 Chen, Abecasis (CR39) 2007; 81 Perola (CR8) 2007; 3 Weedon (CR12) 2007; 39 Yeager (CR15) 2007; 39 Wichmann, Gieger, Illig (CR16) 2005; 67 Price (CR21) 2008; 4 Purcell (CR38) 2007; 81 Hunter (CR14) 2007; 39 Sjoblom (CR31) 2006; 314 Krek (CR27) 2005; 37 Vartiainen (CR37) 2000; 29 Mayr, Hemann, Bartel (CR24) 2007; 315 Fisher (CR7) 1918; 52 TM Frayling (BFng125_CR5) 2007; 316 J Asp (BFng125_CR32) 2006; 45 JN Hirschhorn (BFng125_CR1) 2005; 6 AL Price (BFng125_CR21) 2008; 4 DJ Hunter (BFng125_CR14) 2007; 39 R Saxena (BFng125_CR4) 2007; 316 S Zollner (BFng125_CR35) 2007; 80 H Chikuda (BFng125_CR30) 2004; 18 CD Johnson (BFng125_CR26) 2007; 67 MN Weedon (BFng125_CR12) 2007; 39 T Sjoblom (BFng125_CR31) 2006; 314 RA Mathias (BFng125_CR9) 2003; 4 S Sanna (BFng125_CR11) 2008; 40 M Yeager (BFng125_CR15) 2007; 39 G Pilia (BFng125_CR17) 2006; 2 PT Chuang (BFng125_CR22) 1999; 397 C Mayr (BFng125_CR24) 2007; 315 WM Chen (BFng125_CR39) 2007; 81 S Purcell (BFng125_CR36) 2003; 19 A Scuteri (BFng125_CR6) 2007; 3 LJ Scott (BFng125_CR13) 2007; 316 RA Fisher (BFng125_CR7) 1918; 52 JN Hirschhorn (BFng125_CR33) 2001; 69 AL Price (BFng125_CR20) 2006; 38 Y Guo (BFng125_CR28) 2006; 384 YS Lee (BFng125_CR25) 2007; 21 A Pfeifer (BFng125_CR29) 1996; 274 M Perola (BFng125_CR8) 2007; 3 B St-Jacques (BFng125_CR23) 1999; 13 CD Campbell (BFng125_CR19) 2005; 37 KE Lohmueller (BFng125_CR34) 2003; 33 A Krek (BFng125_CR27) 2005; 37 D Gunnell (BFng125_CR10) 2001; 23 E Vartiainen (BFng125_CR37) 2000; 29 BFng125_CR18 S Purcell (BFng125_CR38) 2007; 81 BFng125_CR3 HE Wichmann (BFng125_CR16) 2005; 67 JP Higgins (BFng125_CR40) 2003; 327 BFng125_CR2 18443579 - Nat Genet. 2008 May;40(5):489-90. doi: 10.1038/ng0508-489. |
| References_xml | – volume: 4 start-page: S36 issue: Suppl 1 year: 2003 ident: CR9 article-title: Comparison of year-of-exam- and age-matched estimates of heritability in the Framingham Heart Study data publication-title: BMC Genet. doi: 10.1186/1471-2156-4-S1-S36 – volume: 21 start-page: 1025 year: 2007 end-page: 1030 ident: CR25 article-title: The tumor suppressor microRNA represses the oncogene publication-title: Genes Dev. doi: 10.1101/gad.1540407 – volume: 67 start-page: 7713 year: 2007 end-page: 7722 ident: CR26 article-title: The microRNA represses cell proliferation pathways in human cells publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-07-1083 – volume: 397 start-page: 617 year: 1999 end-page: 621 ident: CR22 article-title: Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein publication-title: Nature doi: 10.1038/17611 – ident: CR18 – volume: 316 start-page: 889 year: 2007 end-page: 894 ident: CR5 article-title: A common variant in the gene is associated with body mass index and predisposes to childhood and adult obesity publication-title: Science doi: 10.1126/science.1141634 – volume: 18 start-page: 2418 year: 2004 end-page: 2429 ident: CR30 article-title: Cyclic GMP-dependent protein kinase II is a molecular switch from proliferation to hypertrophic differentiation of chondrocytes publication-title: Genes Dev. doi: 10.1101/gad.1224204 – ident: CR2 – volume: 39 start-page: 870 year: 2007 end-page: 874 ident: CR14 article-title: A genome-wide association study identifies alleles in associated with risk of sporadic postmenopausal breast cancer publication-title: Nat. Genet. doi: 10.1038/ng2075 – volume: 274 start-page: 2082 year: 1996 end-page: 2086 ident: CR29 article-title: Intestinal secretory defects and dwarfism in mice lacking cGMP-dependent protein kinase II publication-title: Science doi: 10.1126/science.274.5295.2082 – volume: 6 start-page: 95 year: 2005 end-page: 108 ident: CR1 article-title: Genome-wide association studies for common diseases and complex traits publication-title: Nat. Rev. Genet. doi: 10.1038/nrg1521 – volume: 3 start-page: e97 year: 2007 ident: CR8 article-title: Combined genome scans for body stature in 6,602 European twins: evidence for common Caucasian loci publication-title: PLoS Genet. doi: 10.1371/journal.pgen.0030097 – volume: 29 start-page: 49 year: 2000 end-page: 56 ident: CR37 article-title: Cardiovascular risk factor changes in Finland, 1972–1997 publication-title: Int. J. Epidemiol. doi: 10.1093/ije/29.1.49 – volume: 3 start-page: e115 year: 2007 ident: CR6 article-title: Genome-wide association scan shows genetic variants in the gene are associated with obesity-related traits publication-title: PLoS Genet. doi: 10.1371/journal.pgen.0030115 – volume: 80 start-page: 605 year: 2007 end-page: 615 ident: CR35 article-title: Overcoming the winner's curse: estimating penetrance parameters from case-control data publication-title: Am. J. Hum. Genet. doi: 10.1086/512821 – volume: 33 start-page: 177 year: 2003 end-page: 182 ident: CR34 article-title: Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease publication-title: Nat. Genet. doi: 10.1038/ng1071 – volume: 69 start-page: 106 year: 2001 end-page: 116 ident: CR33 article-title: Genomewide linkage analysis of stature in multiple populations reveals several regions with evidence of linkage to adult height publication-title: Am. J. Hum. Genet. doi: 10.1086/321287 – volume: 39 start-page: 1245 year: 2007 end-page: 1250 ident: CR12 article-title: A common variant of is associated with adult and childhood height in the general population publication-title: Nat. Genet. doi: 10.1038/ng2121 – volume: 81 start-page: 913 year: 2007 end-page: 926 ident: CR39 article-title: Family-based association tests for genomewide association scans publication-title: Am. J. Hum. Genet. doi: 10.1086/521580 – volume: 23 start-page: 313 year: 2001 end-page: 342 ident: CR10 article-title: Height, leg length, and cancer risk: a systematic review publication-title: Epidemiol. Rev. doi: 10.1093/oxfordjournals.epirev.a000809 – volume: 38 start-page: 904 year: 2006 end-page: 909 ident: CR20 article-title: Principal components analysis corrects for stratification in genome-wide association studies publication-title: Nat. Genet. doi: 10.1038/ng1847 – volume: 37 start-page: 495 year: 2005 end-page: 500 ident: CR27 article-title: Combinatorial microRNA target predictions publication-title: Nat. Genet. doi: 10.1038/ng1536 – volume: 40 start-page: 198 year: 2008 end-page: 203 ident: CR11 article-title: Common variants in the region are associated with variation in human height publication-title: Nat. Genet. doi: 10.1038/ng.74 – volume: 315 start-page: 1576 year: 2007 end-page: 1579 ident: CR24 article-title: Disrupting the pairing between and enhances oncogenic transformation publication-title: Science doi: 10.1126/science.1137999 – volume: 19 start-page: 149 year: 2003 end-page: 150 ident: CR36 article-title: Genetic Power Calculator: design of linkage and association genetic mapping studies of complex traits publication-title: Bioinformatics doi: 10.1093/bioinformatics/19.1.149 – ident: CR3 – volume: 4 start-page: e236 year: 2008 ident: CR21 article-title: Discerning the ancestry of European Americans in genetic association studies publication-title: PLoS Genet. doi: 10.1371/journal.pgen.0030236 – volume: 67 start-page: S26 issue: Suppl. 1 year: 2005 end-page: S30 ident: CR16 article-title: KORA-gen–resource for population genetics, controls and a broad spectrum of disease phenotypes publication-title: Gesundheitswesen doi: 10.1055/s-2005-858226 – volume: 45 start-page: 820 year: 2006 end-page: 828 ident: CR32 article-title: and gene fusions resulting from cryptic, intrachromosomal 8q rearrangements in pleomorphic salivary gland adenomas publication-title: Genes Chromosom. Cancer doi: 10.1002/gcc.20346 – volume: 384 start-page: 51 year: 2006 end-page: 61 ident: CR28 article-title: Identification and characterization of homolog B ( ) in human hepatocellular carcinoma publication-title: Gene doi: 10.1016/j.gene.2006.07.011 – volume: 2 start-page: e132 year: 2006 ident: CR17 article-title: Heritability of cardiovascular and personality traits in 6,148 Sardinians publication-title: PLoS Genet. doi: 10.1371/journal.pgen.0020132 – volume: 52 start-page: 399 year: 1918 end-page: 433 ident: CR7 article-title: The correlation between relatives on the supposition of Mendelian inheritance publication-title: Transactions of the Royal Society of Edinburgh doi: 10.1017/S0080456800012163 – volume: 37 start-page: 868 year: 2005 end-page: 872 ident: CR19 article-title: Demonstrating stratification in a European-American population publication-title: Nat. Genet. doi: 10.1038/ng1607 – volume: 316 start-page: 1331 year: 2007 end-page: 1336 ident: CR4 article-title: Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels publication-title: Science doi: 10.1126/science.1142358 – volume: 316 start-page: 1341 year: 2007 end-page: 1345 ident: CR13 article-title: A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants publication-title: Science doi: 10.1126/science.1142382 – volume: 81 start-page: 559 year: 2007 end-page: 575 ident: CR38 article-title: PLINK: a tool set for whole-genome association and population-based linkage analyses publication-title: Am. J. Hum. Genet. doi: 10.1086/519795 – volume: 39 start-page: 645 year: 2007 end-page: 649 ident: CR15 article-title: Genome-wide association study of prostate cancer identifies a second risk locus at 8q24 publication-title: Nat. Genet. doi: 10.1038/ng2022 – volume: 327 start-page: 557 year: 2003 end-page: 560 ident: CR40 article-title: Measuring inconsistency in meta-analyses publication-title: Br. Med. J. doi: 10.1136/bmj.327.7414.557 – volume: 13 start-page: 2072 year: 1999 end-page: 2086 ident: CR23 article-title: Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation publication-title: Genes Dev. doi: 10.1101/gad.13.16.2072 – volume: 314 start-page: 268 year: 2006 end-page: 274 ident: CR31 article-title: The consensus coding sequences of human breast and colorectal cancers publication-title: Science doi: 10.1126/science.1133427 – volume: 39 start-page: 645 year: 2007 ident: BFng125_CR15 publication-title: Nat. Genet. doi: 10.1038/ng2022 – volume: 316 start-page: 889 year: 2007 ident: BFng125_CR5 publication-title: Science doi: 10.1126/science.1141634 – volume: 327 start-page: 557 year: 2003 ident: BFng125_CR40 publication-title: Br. Med. J. doi: 10.1136/bmj.327.7414.557 – volume: 315 start-page: 1576 year: 2007 ident: BFng125_CR24 publication-title: Science doi: 10.1126/science.1137999 – volume: 45 start-page: 820 year: 2006 ident: BFng125_CR32 publication-title: Genes Chromosom. Cancer doi: 10.1002/gcc.20346 – volume: 69 start-page: 106 year: 2001 ident: BFng125_CR33 publication-title: Am. J. Hum. Genet. doi: 10.1086/321287 – volume: 37 start-page: 868 year: 2005 ident: BFng125_CR19 publication-title: Nat. Genet. doi: 10.1038/ng1607 – volume: 52 start-page: 399 year: 1918 ident: BFng125_CR7 publication-title: Transactions of the Royal Society of Edinburgh doi: 10.1017/S0080456800012163 – volume: 29 start-page: 49 year: 2000 ident: BFng125_CR37 publication-title: Int. J. Epidemiol. doi: 10.1093/ije/29.1.49 – volume: 81 start-page: 913 year: 2007 ident: BFng125_CR39 publication-title: Am. J. Hum. Genet. doi: 10.1086/521580 – ident: BFng125_CR2 doi: 10.1038/nature04226 – volume: 4 start-page: e236 year: 2008 ident: BFng125_CR21 publication-title: PLoS Genet. doi: 10.1371/journal.pgen.0030236 – volume: 13 start-page: 2072 year: 1999 ident: BFng125_CR23 publication-title: Genes Dev. doi: 10.1101/gad.13.16.2072 – volume: 67 start-page: S26 issue: Suppl. 1 year: 2005 ident: BFng125_CR16 publication-title: Gesundheitswesen doi: 10.1055/s-2005-858226 – volume: 21 start-page: 1025 year: 2007 ident: BFng125_CR25 publication-title: Genes Dev. doi: 10.1101/gad.1540407 – volume: 40 start-page: 198 year: 2008 ident: BFng125_CR11 publication-title: Nat. Genet. doi: 10.1038/ng.74 – volume: 2 start-page: e132 year: 2006 ident: BFng125_CR17 publication-title: PLoS Genet. doi: 10.1371/journal.pgen.0020132 – volume: 19 start-page: 149 year: 2003 ident: BFng125_CR36 publication-title: Bioinformatics doi: 10.1093/bioinformatics/19.1.149 – ident: BFng125_CR3 doi: 10.1038/nature05911 – volume: 274 start-page: 2082 year: 1996 ident: BFng125_CR29 publication-title: Science doi: 10.1126/science.274.5295.2082 – volume: 37 start-page: 495 year: 2005 ident: BFng125_CR27 publication-title: Nat. Genet. doi: 10.1038/ng1536 – volume: 316 start-page: 1341 year: 2007 ident: BFng125_CR13 publication-title: Science doi: 10.1126/science.1142382 – volume: 3 start-page: e115 year: 2007 ident: BFng125_CR6 publication-title: PLoS Genet. doi: 10.1371/journal.pgen.0030115 – ident: BFng125_CR18 doi: 10.1038/ng.121 – volume: 4 start-page: S36 issue: Suppl 1 year: 2003 ident: BFng125_CR9 publication-title: BMC Genet. doi: 10.1186/1471-2156-4-S1-S36 – volume: 6 start-page: 95 year: 2005 ident: BFng125_CR1 publication-title: Nat. Rev. Genet. doi: 10.1038/nrg1521 – volume: 316 start-page: 1331 year: 2007 ident: BFng125_CR4 publication-title: Science doi: 10.1126/science.1142358 – volume: 3 start-page: e97 year: 2007 ident: BFng125_CR8 publication-title: PLoS Genet. doi: 10.1371/journal.pgen.0030097 – volume: 314 start-page: 268 year: 2006 ident: BFng125_CR31 publication-title: Science doi: 10.1126/science.1133427 – volume: 384 start-page: 51 year: 2006 ident: BFng125_CR28 publication-title: Gene doi: 10.1016/j.gene.2006.07.011 – volume: 18 start-page: 2418 year: 2004 ident: BFng125_CR30 publication-title: Genes Dev. doi: 10.1101/gad.1224204 – volume: 23 start-page: 313 year: 2001 ident: BFng125_CR10 publication-title: Epidemiol. Rev. doi: 10.1093/oxfordjournals.epirev.a000809 – volume: 33 start-page: 177 year: 2003 ident: BFng125_CR34 publication-title: Nat. Genet. doi: 10.1038/ng1071 – volume: 81 start-page: 559 year: 2007 ident: BFng125_CR38 publication-title: Am. J. Hum. Genet. doi: 10.1086/519795 – volume: 38 start-page: 904 year: 2006 ident: BFng125_CR20 publication-title: Nat. Genet. doi: 10.1038/ng1847 – volume: 39 start-page: 870 year: 2007 ident: BFng125_CR14 publication-title: Nat. Genet. doi: 10.1038/ng2075 – volume: 397 start-page: 617 year: 1999 ident: BFng125_CR22 publication-title: Nature doi: 10.1038/17611 – volume: 39 start-page: 1245 year: 2007 ident: BFng125_CR12 publication-title: Nat. Genet. doi: 10.1038/ng2121 – volume: 67 start-page: 7713 year: 2007 ident: BFng125_CR26 publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-07-1083 – volume: 80 start-page: 605 year: 2007 ident: BFng125_CR35 publication-title: Am. J. Hum. Genet. doi: 10.1086/512821 – reference: 18443579 - Nat Genet. 2008 May;40(5):489-90. doi: 10.1038/ng0508-489. |
| SSID | ssj0014408 |
| Score | 2.4697015 |
| SecondaryResourceType | review_article |
| Snippet | Height is a classic polygenic trait, reflecting the combined influence of multiple as-yet-undiscovered genetic factors. We carried out a meta-analysis of... Height is a classic polygenic trait, reflecting the combined influence of multiple as-yet- undiscovered genetic factors. We carried out a meta-analysis of... |
| SourceID | swepub pubmedcentral proquest gale pubmed pascalfrancis crossref springer |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 584 |
| SubjectTerms | Agriculture Animal Genetics and Genomics Biological and medical sciences Biomedical and Life Sciences Biomedical research Biomedicine Body Height - genetics Cancer Cancer Research Chromatin remodeling Clinical Medicine Diabetes Endocrinology and Diabetes Endokrinologi och diabetes Fundamental and applied biological sciences. Psychology Gene Function Gene loci Genetic aspects Genetic factors Genetic Linkage Genetic variation Genetics Genetics of eukaryotes. Biological and molecular evolution Genome, Human Hedgehog protein Height Human Genetics Humans Identification and classification Klinisk medicin Medical and Health Sciences Medicin och hälsovetenskap Meta-analysis Physical growth Physiological aspects Polygenic inheritance Polymorphism, Single Nucleotide Quantitative trait loci Reviews Sample size Signal transduction Single-nucleotide polymorphism Stature Studies |
| Title | Identification of ten loci associated with height highlights new biological pathways in human growth |
| URI | https://link.springer.com/article/10.1038/ng.125 https://www.ncbi.nlm.nih.gov/pubmed/18391950 https://www.proquest.com/docview/222648998 https://www.proquest.com/docview/20778272 https://www.proquest.com/docview/69151096 https://pubmed.ncbi.nlm.nih.gov/PMC2687076 https://lup.lub.lu.se/record/1205108 oai:portal.research.lu.se:publications/ce9240ff-d437-4665-8a68-9402c329cdfd |
| Volume | 40 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3db9MwELdgExISQnxTNoqFQDyFpa5jx09oTJ0GDwMNhipeLCe220pVWkgrtP-eu9jNln0gHlJV8unk-C73YZ_vR8gbV2QDK5RPDFcs4VkBnxRE9omVzrvUSGZ8UyB7LI5O-edxNo61OXUsq9zYxMZQ20WJe-R7DG98YnLwYfkrQdAoPFyNCBq3yTZ2LsOKLjlu8y08tgw34QSmSXhKGaCFhvleNXk_QHTsC74oWuR7S1PD6vgAa3Fd3Hm1fLI9Q73Ub7TxUYcPyP0YXNL9oA0PyS1XPSJ3Atzk2WNiw61cH7fp6MJTiJgpuLMZNVFMzlLcmqXTZsuUYjfjOf6rKcTfNLRsQrlShDL-Y85qOqtoA_RHJ5DRr6ZPyOnh6PvBURJRFpJSynyVCCckJA2lLCxTnvOhlxakl3uT54KD9bMwwguVMmVSZkDizLsB-H3JCmfB8T0lW9Wics8JHRglnfFSidzxLPPKQbZUDGUBTs_4PO2Rt5v11mVsQY5IGHPdHIUPc11NNMilR161dMvQdOMKxWsUl8YOFhWWyEzMuq71py8_9D4CADSByU1E3046RO8ikV_AXEoTryXAG2FnrA7lbocSvsOyM9zvqE47c8SoV0oCwc5Gl3Q0FLVu1RreuR1Fzlj7VrnFGkhSkBOT7GYKoSBug1y0R54FzTxfNYh_Eei3R2RHZ1sC7C7eHalm06bLOBNgyiXwpBvtPp_1ZWGMgtZ3uM7XS3gKeHTtdOkg0U-915YPpeZCZDo3IteKp6yE9Smttz3y8xo-IQ3VsffVNPJbXtjU_i_mL_65-jvkbigEwkrWXbK1-r12LyHaXBX9xqbAb34w6JPtj6Pjryd_AUOthcQ |
| linkProvider | ProQuest |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3db9MwELemTggkhPimbGwWYuIpLHXcOHlAaECnlo2CxjZNvBgntttKVVKWVlP_KP5H7vK1ZR-Ilz1EiuSTZfvOvjvf-X6EvDFRt6P90DqKh8zh3Qi2FFj2jhbGGlcJpmyeIDv0-0f8y0n3ZIX8qd7CYFpldSbmB7VOY7wj32b44hOdgw-z3w6CRmFwtULQKKRizyzPwGPL3g8-A3u3GNvtHX7qOyWogBMLEcwd3_gCbORYRJqFlnPPCg2DDawKAp_DZtfQwqPQZaFymYIJMms6oOYEi4zuYJ0DOPFXuQeeTIusfuwNvx_UYQuEb87Dqz46ZhgXLcCMvGA7Gb3rIB73Be1X6oD7M5UBP2wBpHGdpXs1YbOO2l6qcJprxd2H5EFpztKdQv4ekRWTPCZ3CoDL5ROii3fAtrwYpKmlYKNTUKATqkrBMJriZTAd55e0FOsnT_Evo2Dx06JIFEoSRfDkM7XM6CShObQgHZ2mZ_PxU3J0Kyx4RlpJmpgXhHZUKIyyIvQDw7tdGxrwzyJPRKBmlQ3cNtmq1lvGZdFzxN6Yyjz47gUyGUngS5ts1nSzoszHFYrXyC6JNTMSTMoZqUWWycG3Y7mDkAO5KXQT0Y-DBtHbksimMJZYlQ8hYEZYi6tBud6ghJ0fN5o3GqJTj5y5HlgZAgjWKlmS5dGUyXojwZzrVuwZs-0Sky6AxAU-McFupvBDsBTB-22T54Vknq8aWNwILdwmoiGzNQHWM2-2JJNxXtec-aA8BPRJK-k-H_VlZvQKqW_0Ol3M4Ivgk5mRsQnBWrVWau4JyX2_KwPlBzLkLothfWJtdZv8vKafwvGVZbWtcdnf7MI1-n91_vKfq79J7vYPv-7L_cFwb43cK9KQMI92nbTmpwvzCmzdebRRnjCU_LrtQ-0vqn7Cug |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3db9MwELemIRASQnxTNjYLMfEUmjgfTh4QmtiqlaGBgKGJF-MkdlupSsrSquqfxn_HXexkyz4QL3uIFMkny_ad78M-34-Q1yoNvTxKtCODhDlBmMKWAs_eybnSypWcSV0nyB5FB8fBx5PwZI38ad7CYFploxNrRZ2XGZ6R9xm--MTgoK9tVsSXvcH72W8HAaTworVB0zAScqhWS4jeqnfDPWD1DmOD_e8fDhwLMOBknMdzJ1IRB38542nOEh0EvuY5DDzWMo6jADZ-Di1BmrgskS6TMFmmlQcmj7NU5R7WPADtf4v7oYdbjJ-0sR5emZpXeBGGaHhDamCN_LhfjN56iMx9zg5aa3BvJivgjDaQGlf5vJdTN9v72wu1Tmv7OHhA7lvHlu4aSXxI1lTxiNw2UJerxyQ3L4K1PSKkpabgrVMwpRMqrYionOKxMB3Xx7UUKylP8a-i4PtTUy4KZYoijPJSrio6KWgNMkhHp-VyPn5Cjm-EAU_JelEW6jmhnky4kponUayCMNSJgkgt9XkKBlfq2O2RnWa9RWbLnyMKx1TU1_B-LIqRAL70yHZLNzMFPy5RvEJ2CayeUaAgjuSiqsTw8w-xi-ADtVN0HdG3rx2iN5ZIlzCWTNonETAjrMrVodzsUIIOyDrNWx3RaUfOXB_8DQ4EG40sCaukKtFuKZhz24o9Y95docoFkLjAJ8bZ9RRRAj4jxME98sxI5tmqge-NIMM9wjsy2xJgZfNuSzEZ1xXOWQRmhEOftJHus1FfZMa-kfpOr9PFDL4UPlEpkakE_FatRR74XARRFIpYRrFIApdlsD5ZrvMe-XlFPyYEFrbu1tj2Nzt3oP5fnb_45-pvkzugysSn4dHhBrlr8pEwoXaTrM9PF-olOL3zdKtWL5T8uml99hcnjcWK |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Identification+of+ten+loci+associated+with+height+highlights+new+biological+pathways+in+human+growth&rft.jtitle=Nature+genetics&rft.date=2008-05-01&rft.pub=Nature+Publishing+Group&rft.issn=1061-4036&rft.volume=40&rft.issue=5&rft.spage=584&rft_id=info:doi/10.1038%2Fng.125&rft.externalDocID=A186822415 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1061-4036&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1061-4036&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1061-4036&client=summon |