Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor

• Published in: Nature (London) Vol. 503; no. 7477; pp. 535 - 538
• Main Authors: Ge, Xing-Yi, Li, Jia-Lu, Yang, Xing-Lou, Chmura, Aleksei A., Zhu, Guangjian, Epstein, Jonathan H., Mazet, Jonna K., Hu, Ben, Zhang, Wei, Peng, Cheng, Zhang, Yu-Ji, Luo, Chu-Ming, Tan, Bing, Wang, Ning, Zhu, Yan, Crameri, Gary, Zhang, Shu-Yi, Wang, Lin-Fa, Daszak, Peter, Shi, Zheng-Li
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 29.11.2013; Nature Publishing Group
• Subjects: 631/326/596/2078; Angiotensin-Converting Enzyme 2; Animals; Bats; China; Chiroptera - virology; Chlorocebus aethiops; Coronaviruses; COVID-19; Disease Reservoirs - virology; Distribution; Epidemics; Feces - virology; Fluorescent Antibody Technique; Genes; Genetic aspects; Genetic diversity; Genome, Viral - genetics; Genomes; Health aspects; Host Specificity; Humanities and Social Sciences; Humans; Identification and classification; letter; Microbiology; Molecular Sequence Data; multidisciplinary; Pandemics; Pandemics - prevention & control; Pandemics - veterinary; Peptidyl-Dipeptidase A - genetics; Peptidyl-Dipeptidase A - metabolism; Phylogenetics; Proteins; Public health; Real-Time Polymerase Chain Reaction; Receptors, Virus - genetics; Receptors, Virus - metabolism; RNA polymerase; SARS Virus - genetics; SARS Virus - isolation & purification; SARS Virus - metabolism; SARS Virus - ultrastructure; Science; Severe acute respiratory syndrome; Severe Acute Respiratory Syndrome - prevention & control; Severe Acute Respiratory Syndrome - transmission; Severe Acute Respiratory Syndrome - veterinary; Severe Acute Respiratory Syndrome - virology; Species Specificity; Spike Glycoprotein, Coronavirus - chemistry; Spike Glycoprotein, Coronavirus - metabolism; Vero Cells; Viral genetics; Virion - isolation & purification; Virion - ultrastructure; Virus Internalization; Viverridae - metabolism; Wildlife; Zoonoses; China

Whole-genome sequences of two novel SARS-CoV-related bat coronaviruses, in addition to a live isolate of a bat SARS-like coronavirus, are reported; the live isolate can infect human cells using ACE2, providing the strongest evidence to date that Chinese horseshoe bats are natural reservoirs of SARS-...