Systematic discovery of regulatory motifs in human promoters and 3′ UTRs by comparison of several mammals

• Published in: Nature (London) Vol. 434; no. 7031; pp. 338 - 345
• Main Authors: Xie, Xiaohui, Lu, Jun, Kulbokas, E. J., Golub, Todd R., Mootha, Vamsi, Lindblad-Toh, Kerstin, Lander, Eric S., Kellis, Manolis
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 17.03.2005; Nature Publishing; Nature Publishing Group
• Subjects: 3' Untranslated Regions - genetics; Animals; Base Sequence; Biological and medical sciences; Biomedical research; Comparative analysis; Conserved Sequence - genetics; Dogs; Fundamental and applied biological sciences. Psychology; Gene Expression Profiling; Genes. Genome; Genomics; Human subjects; Humanities and Social Sciences; Humans; Mammals; Mammals - genetics; Mice; MicroRNAs - genetics; MicroRNAs - metabolism; Molecular and cellular biology; Molecular genetics; Molecular Sequence Data; multidisciplinary; Organ Specificity; Promoter Regions, Genetic - genetics; Rats; Rodents; Science; Science (multidisciplinary); Sequence Alignment; Human; Vertebrata; Regulation(control); Mammalia; Transcription; Transcription promoter; Non coding sequence; Identification; Binding site; Transcription factor; Genome; Comparative study

Comprehensive identification of all functional elements encoded in the human genome is a fundamental need in biomedical research. Here, we present a comparative analysis of the human, mouse, rat and dog genomes to create a systematic catalogue of common regulatory motifs in promoters and 3′ untransl...