Stress-induced gene expression in the paraventricular nucleus of hypothalamus in the mouse strains DBA/2J and C57BL/6J – potential signalling pathways involved

• Published in: Pharmacopsychiatry
• Main Authors: Tsolakidou, A, Czibere, L, Pütz, B, Trümbach, D, Panhuysen, M, Deussing, JM, Wurst, W, Sillaber, I, Landgraf, R, Holsboer, F, Rein, T
• Format: Conference Proceeding
• Language: English
• Published: 01.09.2009
• ISSN: 0176-3679; 1439-0795
• DOI: 10.1055/s-0029-1240237

The pivotal role of stress in the precipitation of psychiatric diseases is generally accepted. To further elucidate the underlying molecular mechanisms, gene networks and signalling cascades, we investigated the impact of an acute stressor, forced swimming, on the expression profile in the paraventricular nucleus. We performed this study in C57BL/6 and DBA/2J mice, an established paradigm of differenzial reaction to stress. Our results revealed a time-phased transcriptional response to stress in both mouse strains. Moreover, a search for connections between the regulated genes resulted in potential novel signalling pathways in stress. In particular, GNAi2 and APP were detected as stress-regulated genes in DBA/2J mice, and together with other genes, seem to be integrated into stress-responsive pathways and gene networks in PVN.