Drosophila RNAi screen identifies host genes important for influenza virus replication

• Published in: Nature Vol. 454; no. 7206; pp. 890 - 893
• Main Authors: Hao, Linhui, Sakurai, Akira, Watanabe, Tokiko, Sorensen, Ericka, Nidom, Chairul A., Newton, Michael A., Ahlquist, Paul, Kawaoka, Yoshihiro
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 14.08.2008; Nature Publishing; Nature Publishing Group
• Subjects: Analysis; Animals; Biological and medical sciences; Cell Line; Cellular biology; Drosophila; Drosophila melanogaster - genetics; Drosophila melanogaster - virology; Fundamental and applied biological sciences. Psychology; Gene Expression Regulation; Genetic aspects; Genetic screening; Genetics; Genome, Insect - genetics; Host-Pathogen Interactions - physiology; Host-virus relationships; Humanities and Social Sciences; Humans; Identification and classification; Influenza; Influenza A virus - physiology; Influenza virus; Influenza viruses; Insects; letter; Luciferases, Renilla - metabolism; Mammals; Microbiology; multidisciplinary; Pandemics; Proteins; Renilla; Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains; Ribonucleic acid; RNA; RNA Interference; Science; Science (multidisciplinary); Testing; Vaccinia virus; Vaccinia virus - physiology; Vesicular stomatitis virus; Vesiculovirus - physiology; Virology; Virus replication; Virus Replication - physiology; Viruses; Japan; RNA interference; Insecta; Orthomyxoviridae; Host agent relation; Identification; Influenzavirus; Drosophilidae; Virus; Gene silencing; Gene; Arthropoda; Replication; Invertebrata; Drosophila melanogaster; Diptera

Flu in a fruit fly: the search for new antivirals Although several alternative antivirals are available for the treatment of influenza virus infection, the risk that viruses resistant to these drugs will emerge means it is important to continue the search for new antiviral targets. Hao et al . have...