Liver function assessment using sonazoid, correlation analysis with conventional biochemical marker ICG R15

• Published in: Ultraschall in der Medizin - European Journal of Ultrasound
• Main Authors: Cho, JH, Gwon, HJ
• Format: Conference Proceeding
• Language: English
• Published: 18.08.2016
• ISSN: 0172-4614; 1438-8782
• DOI: 10.1055/s-0036-1587716

Purpose: We analyzed the pattern of time-intensity curves (TICs) of the liver parenchyma on contrast-enhanced ultrasonography (CEUS), using Kupffer cell specific contrast agent; Sonazoid. The aim of the present study is to assess the diagnostic accuracy of the parameters of the time-intensity curves (TICs) for assessment of liver function. Methods and Material: Between June 2013 and October 2014, total 52 patients (44 men, 8 women) who underwent contrast enhanced ultrasonography and indocyanine green (ICG) tests due to focal liver lesion requiring surgical or ablational treatment were enrolled. We evaluated the hemodynamic-related parameters of TICs such as rise time (s), time to peak (s), peak intensity (dB), time from peak to one half (s), area under curve (dB*s), mean transit time (s). And compared these parameters with the conventional serologic test, indocyanine green retention rate at 15 minutes (IGC R15). Results: There were no significant relationship between rise time (s), time to peak (s), peak intensity (dB), area under curve (dB*s) and mean transit time (s) with ICG R15. However, correlation between time from peak to one half (s) and ICG R15 was statistically significant. Time from peak to one half was relatively proportional to ICG R15. The cutoff value of 149 seconds was determined for the time from peak to one half for abnormal ICG R15 (> 14). And sensitivity and specificity were 85.7% and 92.3% for detecting abnormal ICG R15. Conclusion: Time from peak to one half is a useful parameter of TICs using CEUS to predict post-operative liver function.