Accumulation of succinate controls activation of adipose tissue thermogenesis

• Published in: Nature (London) Vol. 560; no. 7716; pp. 102 - 106
• Main Authors: Mills, Evanna L., Pierce, Kerry A., Jedrychowski, Mark P., Garrity, Ryan, Winther, Sally, Vidoni, Sara, Yoneshiro, Takeshi, Spinelli, Jessica B., Lu, Gina Z., Kazak, Lawrence, Banks, Alexander S., Haigis, Marcia C., Kajimura, Shingo, Murphy, Michael P., Gygi, Steven P., Clish, Clary B., Chouchani, Edward T.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.08.2018; Nature Publishing Group
• Subjects: 631/45/320; 631/80/304; 64; 64/60; 82; 82/1; 82/16; 82/58; 82/80; 96/1; 96/106; 96/98; Accumulation; Activation; Adipocytes; Adipocytes - drug effects; Adipocytes - enzymology; Adipocytes - metabolism; Adipose tissue; Adipose tissue (brown); Adipose Tissue, Brown - cytology; Adipose Tissue, Brown - drug effects; Adipose Tissue, Brown - enzymology; Adipose Tissue, Brown - metabolism; Adipose Tissue, White - cytology; Adipose Tissue, White - drug effects; Adipose Tissue, White - enzymology; Adipose Tissue, White - metabolism; Animals; Body fat; Control; Cyclic adenosine monophosphate; Cyclic AMP; Dehydrogenase; Dehydrogenases; Energy; External stimuli; Female; Glucose; Glucose tolerance; Humanities and Social Sciences; Hypotheses; Kinases; Letter; Lipolysis; Male; Metabolic disorders; Metabolism; Metabolites; Metabolomics; Mice; multidisciplinary; Obesity - metabolism; Obesity - prevention & control; Oxidation; Oxidation-Reduction - drug effects; Oxidation-reduction reactions; Oxygen; Pharmacology; Physiological aspects; Protein kinase A; Protein kinases; Proteins; Reactive oxygen species; Reactive Oxygen Species - metabolism; Respiration; Rodents; Science; Science (multidisciplinary); Signal transduction; Signaling; Succinate dehydrogenase; Succinate Dehydrogenase - metabolism; Succinates; Succinic Acid - metabolism; Succinic Acid - pharmacology; Thermogenesis; Thermogenesis - drug effects; Thermogenesis - physiology; Tricarboxylic acid cycle; Uncoupling Protein 1 - metabolism

Thermogenesis by brown and beige adipose tissue, which requires activation by external stimuli, can counter metabolic disease 1 . Thermogenic respiration is initiated by adipocyte lipolysis through cyclic AMP–protein kinase A signalling; this pathway has been subject to longstanding clinical investi...