Endogenous FGF21-signaling controls paradoxical obesity resistance of UCP1-deficient mice

• Published in: Nature communications Vol. 11; no. 1; pp. 624 - 12
• Main Authors: Keipert, Susanne, Lutter, Dominik, Schroeder, Bjoern O., Brandt, Daniel, Ståhlman, Marcus, Schwarzmayr, Thomas, Graf, Elisabeth, Fuchs, Helmut, de Angelis, Martin Hrabe, Tschöp, Matthias H., Rozman, Jan, Jastroch, Martin
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 31.01.2020; Nature Publishing Group; Nature Portfolio
• Subjects: 38/39; 38/91; 631/443; 631/443/319; 64/110; 64/60; Adipose tissue; Adipose tissue (brown); Adipose Tissue, Brown - metabolism; Adipose Tissue, White - metabolism; Animal models; Animals; balance; bile-acids; brown adipose-tissue; Browning; Cardiac and Cardiovascular Systems; cold-exposure; Diet; diet-induced thermogenesis; Endocrinology and Diabetes; Endokrinologi och diabetes; Energy expenditure; Energy Metabolism; fat; fgf21; Fibroblast Growth Factors - genetics; Fibroblast Growth Factors - metabolism; Humanities and Social Sciences; Humans; Kardiologi; Lipid metabolism; Lipids; Male; Metabolism; Metabolomics; Mice; Mice, Inbred C57BL; Mice, Knockout; multidisciplinary; Obesity; Obesity - genetics; Obesity - metabolism; Organs; Oxidative metabolism; Proteins; Resistance factors; Room temperature; Science; Science & Technology - Other Topics; Science (multidisciplinary); Signal Transduction; Signaling; Thermogenesis; ucp1; Uncoupling protein 1; Uncoupling Protein 1 - genetics; Uncoupling Protein 1 - metabolism; Urine; white

Uncoupling protein 1 (UCP1) executes thermogenesis in brown adipose tissue, which is a major focus of human obesity research. Although the UCP1-knockout (UCP1 KO) mouse represents the most frequently applied animal model to judge the anti-obesity effects of UCP1, the assessment is confounded by unkn...