Chemico-genetic discovery of astrocytic control of inhibition in vivo

• Published in: Nature (London) Vol. 588; no. 7837; pp. 296 - 302
• Main Authors: Takano, Tetsuya, Wallace, John T., Baldwin, Katherine T., Purkey, Alicia M., Uezu, Akiyoshi, Courtland, Jamie L., Soderblom, Erik J., Shimogori, Tomomi, Maness, Patricia F., Eroglu, Cagla, Soderling, Scott H.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 10.12.2020; Nature Publishing Group
• Subjects: 13; 13/106; 14; 14/19; 631/378/2571/2577; 631/378/2596/1308; 631/378/87; 82; 82/58; Analysis; Animals; Astrocytes; Astrocytes - chemistry; Astrocytes - cytology; Astrocytes - metabolism; Cell adhesion; Cell adhesion & migration; Cell adhesion molecules; Cell Adhesion Molecules, Neuronal - metabolism; Cell Shape; Cell surface; Central nervous system; Chemical properties; Complementation; Control; CRISPR; Depletion; Female; GABAergic Neurons - cytology; GABAergic Neurons - metabolism; gamma-Aminobutyric Acid - metabolism; Genetic aspects; Genetic Complementation Test; Gephyrin; Glutamatergic transmission; HEK293 Cells; Humanities and Social Sciences; Humans; Inhibition (Neurophysiology); Male; Mice; Molecular modelling; Morphogenesis; multidisciplinary; Nervous system; Neural Inhibition; Neurons; Neurons - cytology; Neurons - metabolism; Neuropil; Proteins; Proteome - metabolism; Proteomes; Proteomics; Science; Science (multidisciplinary); Synapses; Synapses - chemistry; Synapses - metabolism; Synaptic density; Synaptogenesis; γ-Aminobutyric acid; United States

Perisynaptic astrocytic processes are an integral part of central nervous system synapses 1 , 2 ; however, the molecular mechanisms that govern astrocyte–synapse adhesions and how astrocyte contacts control synapse formation and function are largely unknown. Here we use an in vivo chemico-genetic ap...