Stimulation and Inhibition of Angiogenesis by Placental Proliferin and Proliferin-Related Protein

• Published in: Science (American Association for the Advancement of Science) Vol. 266; no. 5190; pp. 1581 - 1584
• Main Authors: Jackson, Dowdy, Volpert, Olga V., Bouck, Noël, Daniel I. H. Linzer
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for the Advancement of Science 02.12.1994; American Association for the Advancement of Science; The American Association for the Advancement of Science
• Subjects: Angiogenesis; Animal migration behavior; Animals; Biological and medical sciences; Cattle; Cell differentiation, maturation, development, hematopoiesis; Cell Movement - drug effects; Cell physiology; Cellular biology; CHO cells; Cornea; Cornea - blood supply; Culture Techniques; Endothelial cells; Endothelium, Vascular - cytology; Endothelium, Vascular - drug effects; Endothelium, Vascular - metabolism; Family (Sociological Unit); Female; Fibroblast Growth Factor 2 - pharmacology; Fundamental and applied biological sciences. Psychology; Glycoproteins - metabolism; Glycoproteins - pharmacology; Growth Substances - metabolism; Growth Substances - pharmacology; Hormones; Individualized Instruction; Intercellular Signaling Peptides and Proteins; Migration; Molecular and cellular biology; Neovascularization; Neovascularization, Pathologic; Placenta; Placenta - blood supply; Pregnancy; Pregnancy proteins; Pregnancy Proteins - pharmacology; Proteins; Rats; Reproduction; Tissue culture techniques; Ungulates; Cell proliferation; Angiogenesis; Vertebrata; Regulation(control); Mammalia; Placenta; Adenohypophyseal hormone; Prolactin; STH

In many mammalian species, the placenta is the site of synthesis of proteins in the prolactin and growth hormone family. Analysis of two such proteins, proliferin (PLF) and proliferin-related protein (PRP), revealed that they are potent regulators of angiogenesis; PLF stimulated and PRP inhibited en...