Dual Effect of Curcumin–Zinc Complex in Controlling Diabetes Mellitus in Experimentally Induced Diabetic Rats
Ultrasound-assisted extraction of curcumin from Curcuma longa was performed in an ultrasonic bath at 30°C using ethanol for 40 min. A successful attempt has been made to prepare curcumin–zinc (Zn) complex using a simple chemical procedure. The complex formation and its stoichiometry were characteriz...
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| Published in | Biological & pharmaceutical bulletin Vol. 39; no. 11; pp. 1774 - 1780 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
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The Pharmaceutical Society of Japan
2016
Pharmaceutical Society of Japan Japan Science and Technology Agency |
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| Abstract | Ultrasound-assisted extraction of curcumin from Curcuma longa was performed in an ultrasonic bath at 30°C using ethanol for 40 min. A successful attempt has been made to prepare curcumin–zinc (Zn) complex using a simple chemical procedure. The complex formation and its stoichiometry were characterized using elemental analysis, Fourier transform (FT)-IR and UV spectroscopy which revealed the interaction of Zn(II) ion (M) with curcumin (ligand, L) to proceed via (ML) complex type formation. Oral administration of curcumin–Zn complex at a concentration of 150 mg/kg body weight/rat/d for 45 d in streptozotocin-induced diabetic rats in comparison to curcumin and/or Zn administration exerted a hypoglycemic effect. A significant reduction in blood glucose, glycosylated hemoglobin (Hb)A1c, and lipid profile parameters with an excellent improvement in plasma insulin levels have been attained. Also, the reduced activities of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), urea, and creatinine in the diabetic rats treated with the complex exhibited the non-toxic nature of the curcumin–Zn complex. Finally, the larger extent of the complex in hyperglycemic improvement in comparison to curcumin and/or Zn supplementation was interpreted by its dual action on glucose and insulin maintenance. |
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| AbstractList | Ultrasound-assisted extraction of curcumin from Curcuma longa was performed in an ultrasonic bath at 30℃ using ethanol for 40 min. A successful attempt has been made to prepare curcumin-zinc (Zn) complex using a simple chemical procedure. The complex formation and its stoichiometry were characterized using elemental analysis, Fourier transform (FT)-IR and UV spectroscopy which revealed the interaction of Zn(II) ion (M) with curcumin (ligand, L) to proceed via (ML) complex type formation. Oral administration of curcumin-Zn complex at a concentration of 150 mg/kg body weight/rat/d for 45d in streptozotocin-induced diabetic rats in comparison to curcumin and/or Zn administration exerted a hypoglycemic effect. A significant reduction in blood glucose, glycosylated hemoglobin (Hb)A1c, and lipid profile parameters with an excellent improvement in plasma insulin levels have been attained. Also, the reduced activities of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), urea, and creatinine in the diabetic rats treated with the complex exhibited the non-toxic nature of the curcumin-Zn complex. Finally, the larger extent of the complex in hyperglycemic improvement in comparison to curcumin and/or Zn supplementation was interpreted by its dual action on glucose and insulin maintenance. Ultrasound-assisted extraction of curcumin from Curcuma longa was performed in an ultrasonic bath at 30°C using ethanol for 40 min. A successful attempt has been made to prepare curcumin-zinc (Zn) complex using a simple chemical procedure. The complex formation and its stoichiometry were characterized using elemental analysis, Fourier transform (FT)-IR and UV spectroscopy which revealed the interaction of Zn(II) ion (M) with curcumin (ligand, L) to proceed via (ML) complex type formation. Oral administration of curcumin-Zn complex at a concentration of 150 mg/kg body weight/rat/d for 45 d in streptozotocin-induced diabetic rats in comparison to curcumin and/or Zn administration exerted a hypoglycemic effect. A significant reduction in blood glucose, glycosylated hemoglobin (Hb)A1c, and lipid profile parameters with an excellent improvement in plasma insulin levels have been attained. Also, the reduced activities of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), urea, and creatinine in the diabetic rats treated with the complex exhibited the non-toxic nature of the curcumin-Zn complex. Finally, the larger extent of the complex in hyperglycemic improvement in comparison to curcumin and/or Zn supplementation was interpreted by its dual action on glucose and insulin maintenance. |
| Author | Fatah, Hala Salah Abdel Al-Ali, Khalil El-Badry, Yaser Abdel-Moemen |
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| Cites_doi | 10.1056/NEJM197102182840703 10.1080/07315724.2009.10719772 10.1002/mnfr.200700184 10.1016/j.foodhyd.2014.07.011 10.1016/j.lwt.2014.06.009 10.1016/j.ejphar.2007.12.011 10.2337/dc10-S062 10.1186/1758-5996-4-30 10.1016/S0021-9258(19)52451-6 10.1016/j.ejphar.2012.01.022 10.1002/biof.1062 10.1016/j.bbagen.2014.05.017 10.1136/jcp.22.2.158 10.1515/JBCPP.2005.16.4.257 10.2174/1871525711311010006 10.1016/S0009-9120(84)90200-5 10.1016/j.jff.2015.02.044 10.1016/S0021-9258(18)71594-9 10.1016/j.ejphar.2007.09.002 10.1331/108658002763508515 10.1016/j.foodchem.2011.04.065 10.1007/BF00275265 10.1016/j.molstruc.2010.09.049 10.1172/JCI102012 10.1038/bjp.2008.311 10.1016/j.jep.2004.07.029 10.1016/j.bcp.2007.02.006 10.1016/j.fct.2008.03.020 10.1172/JCI111286 10.1007/BF02867969 10.1016/S0006-3495(93)81397-3 10.1166/jbn.2015.2041 10.1093/ajcp/21.3_ts.275 10.1016/j.taap.2014.12.003 10.1038/414782a 10.1016/0963-6897(95)00020-X 10.1124/pr.110.004044 10.1016/j.foodchem.2014.09.131 10.1210/jcem-61-4-741 10.1177/0003319709356424 |
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| Title | Dual Effect of Curcumin–Zinc Complex in Controlling Diabetes Mellitus in Experimentally Induced Diabetic Rats |
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| ispartofPNX | Biological and Pharmaceutical Bulletin, 2016/11/01, Vol.39(11), pp.1774-1780 |
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