Optimizing the lipidomics workflow for clinical studies—practical considerations

• Published in: Analytical and bioanalytical chemistry Vol. 407; no. 17; pp. 4973 - 4993
• Main Authors: Hyotyläinen, Tuulia, Oresic, Matej
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.07.2015; Springer; Springer Nature B.V
• Subjects: Analytical Chemistry; analytical methods; Anticoagulants; Biochemistry; Biomarkers; Biomarkers - analysis; Biomarkers - blood; Biomarkers - metabolism; Blood; blood lipids; Characterization and Evaluation of Materials; Chemistry; Chemistry and Materials Science; Chromatography; Chromatography, Liquid - methods; Cohort analysis; Data processing; Environmental factors; Fasting; Fatty acids; Food Science; gender; Humans; Laboratory Medicine; Lipid Metabolism; Lipidomics; Lipids; Lipids - analysis; Lipids - blood; Mass spectrometry; Mass Spectrometry - methods; Mathematical analysis; measuring; Medical research; Metabolites; Metabolomics; Metabolomics - methods; Methods; Monitoring/Environmental Analysis; Optimization; Physiology; Plasma; prediction; Preprocessing; Review; Scientific imaging; Systems biology; Systems Biology - methods; Systemsmedicine; Validation Studies as Topic; Workflow; Biomarkers; Metabolomics; Lipidomics; Systems biology; Systems medicine; Mass spectrometry

Lipidomics is increasingly being used in clinical research, offering new opportunities for disease prediction and detection. One of the key challenges of clinical applications of lipidomics is the high sensitivity of measured lipid levels to many analytical, physiological, and environmental factors,...