Novel tau fragments in cerebrospinal fluid: relation to tangle pathology and cognitive decline in Alzheimer’s disease

• Published in: Acta neuropathologica Vol. 137; no. 2; pp. 279 - 296
• Main Authors: Cicognola, Claudia, Brinkmalm, Gunnar, Wahlgren, Jessica, Portelius, Erik, Gobom, Johan, Cullen, Nicholas C., Hansson, Oskar, Parnetti, Lucilla, Constantinescu, Radu, Wildsmith, Kristin, Chen, Hsu-Hsin, Beach, Thomas G., Lashley, Tammaryn, Zetterberg, Henrik, Blennow, Kaj, Höglund, Kina
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.02.2019; Springer; Springer Nature B.V
• Subjects: Advertising executives; Aged; Alzheimer Disease - cerebrospinal fluid; Alzheimer Disease - metabolism; Alzheimer Disease - pathology; Alzheimer's disease; Amino acids; Amyloid beta-Peptides - cerebrospinal fluid; Amyloid beta-Peptides - metabolism; Antibodies; Antigenic determinants; Biomarkers - cerebrospinal fluid; Brain - metabolism; Brain - pathology; Cerebrospinal fluid; Clinical Medicine; Cognitive ability; Cognitive Dysfunction - cerebrospinal fluid; Cognitive Dysfunction - metabolism; Cognitive Dysfunction - pathology; Cohort Studies; Enzyme inhibitors; Epitopes; Female; Humans; Immunoassay; Immunohistochemistry; Klinisk medicin; Male; Mass spectrometry; Mass spectroscopy; Medical and Health Sciences; Medical schools; Medicin och hälsovetenskap; Medicine; Medicine & Public Health; Neurofibrillary tangles; Neurologi; Neurology; Neurons; Neurophysiology; Neuropil; Neurosciences; Neurovetenskaper; Original Paper; Pathology; Patients; Peptide Fragments - cerebrospinal fluid; Peptides; Protein binding; Spectroscopy; Tau fragments; Tau protein; tau Proteins - cerebrospinal fluid; tau Proteins - metabolism; Tau fragments; Immunohistochemistry; Cerebrospinal fluid; Alzheimer’s disease; Mass spectrometry

Tau is an axonal microtubule-binding protein. Tau pathology in brain and increased tau concentration in the cerebrospinal fluid (CSF) are hallmarks of Alzheimer’s disease (AD). Most of tau in CSF is present as fragments. We immunoprecipitated tau from CSF and identified several endogenous peptides e...