Rejection of bronchus transplants in humanized mice is regulated by allogeneic CD4+CD25+ T cells

• Published in: The Thoracic and cardiovascular surgeon
• Main Authors: Knöfel, AK, Madrahimov, N, Salman, J, Büchler, G, Avsar, M, Sommer, W, Jonigk, D, Haverich, A, Warnecke, G
• Format: Conference Proceeding
• Language: English
• Published: 23.01.2013

Introduction: Bronchiolitis obliterans syndrome (BOS) limits long term survival after lung transplantation. CD4+CD25+ regulatory T cells are known to counteract acute rejection and may as well inhibit chronic rejection, i.e. BOS. We have developed a humanized mouse model in immune deficient NRG mice...