The association of occupational metals exposure and oxidative damage, telomere shortening in fitness equipments manufacturing workers
The welding is the major working process in fitness equipment manufacturing industry, and International Agency for Research on Cancer has classified welding fumes as possibly carcinogenic to humans (Group 2B). The present study aimed to evaluate associations between the occupational exposure of meta...
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| Published in | Industrial Health Vol. 55; no. 4; pp. 345 - 353 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Japan
National Institute of Occupational Safety and Health
2017
National Institute of Occupational Safety and Health, Japan National Institute of Occupational Safety and Health, Japan (JNIOSH) |
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| Abstract | The welding is the major working process in fitness equipment manufacturing industry, and International Agency for Research on Cancer has classified welding fumes as possibly carcinogenic to humans (Group 2B). The present study aimed to evaluate associations between the occupational exposure of metals and oxidative damage and telomere length shortening in workers involved in the manufacture of fitness equipment. The blood metal concentrations were monitored and malondialdehyde (MDA), alkaline Comet assay was determined as oxidative damage in 117 workers from two representative fitness equipment manufacturing plants. MDA levels varied according to workers' roles at the manufacturing plants, and showed a trend as cutting>painting>welding>administration workers. Welders had marginally shorter average telomere lengths than the administrative workers (p=0.058). Cr and Mn levels were significantly greater in welders than they were in administrative workers. There were significantly positive correlations between MDA and Cr and Mn levels, the major components of welding fume. However, the association would be eliminated if co-metals exposure were considered simultaneously. In future, telomere length and MDA might be potential biomarkers for predicting cardiovascular disease in co-metals exposed workers. |
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| AbstractList | The welding is the major working process in fitness equipment manufacturing industry, and International Agency for Research on Cancer has classifed welding fumes as possibly carcinogenic to humans (Group 2B). The present study aimed to evaluate associations between the occupational exposure of metals and oxidative damage and telomere length shortening in workers involved in the manufacture of fitness equipment. The blood metal concentrations were monitored and malondialdehyde (MDA), alkaline Comet assay was determined as oxidative damage in 117 workers from two representative fitness equipment manufacturing plants. MDA levels varied according to workers' roles at the manufacturing plants, and showed a trend as cutting>painting>welding> administration workers. Welders had marginally shorter average telomere lengths than the administrative workers (p=0.058). Cr and Mn levels were significantly greater in welders than they were in administrative workers. There were significantly positive correlations between MDA and Cr and Mn levels, the major components of welding fume. However, the association would be eliminated if co-metals exposure were considered simultaneously. In future, telomere length and MDA might be potential biomarkers for predicting cardiovascular disease in co-metals exposed workers. The welding is the major working process in fitness equipment manufacturing industry, and International Agency for Research on Cancer has classified welding fumes as possibly carcinogenic to humans (Group 2B). The present study aimed to evaluate associations between the occupational exposure of metals and oxidative damage and telomere length shortening in workers involved in the manufacture of fitness equipment. The blood metal concentrations were monitored and malondialdehyde (MDA), alkaline Comet assay was determined as oxidative damage in 117 workers from two representative fitness equipment manufacturing plants. MDA levels varied according to workers’ roles at the manufacturing plants, and showed a trend as cutting>painting>welding>administration workers. Welders had marginally shorter average telomere lengths than the administrative workers ( p =0.058). Cr and Mn levels were significantly greater in welders than they were in administrative workers. There were significantly positive correlations between MDA and Cr and Mn levels, the major components of welding fume. However, the association would be eliminated if co-metals exposure were considered simultaneously. In future, telomere length and MDA might be potential biomarkers for predicting cardiovascular disease in co-metals exposed workers. The welding is the major working process in fitness equipment manufacturing industry, and International Agency for Research on Cancer has classified welding fumes as possibly carcinogenic to humans (Group 2B). The present study aimed to evaluate associations between the occupational exposure of metals and oxidative damage and telomere length shortening in workers involved in the manufacture of fitness equipment. The blood metal concentrations were monitored and malondialdehyde (MDA), alkaline Comet assay was determined as oxidative damage in 117 workers from two representative fitness equipment manufacturing plants. MDA levels varied according to workers' roles at the manufacturing plants, and showed a trend as cutting>painting>welding>administration workers. Welders had marginally shorter average telomere lengths than the administrative workers (p=0.058). Cr and Mn levels were significantly greater in welders than they were in administrative workers. There were significantly positive correlations between MDA and Cr and Mn levels, the major components of welding fume. However, the association would be eliminated if co-metals exposure were considered simultaneously. In future, telomere length and MDA might be potential biomarkers for predicting cardiovascular disease in co-metals exposed workers. The welding is the major working process in fitness equipment manufacturing industry, and International Agency for Research on Cancer has classifed welding fumes as possibly carcinogenic to humans (Group 2B). The present study aimed to evaluate associations between the occupational exposure of metals and oxidative damage and telomere length shortening in workers involved in the manufacture of fitness equipment. The blood metal concentrations were monitored and malondialdehyde (MDA), alkaline Comet assay was determined as oxidative damage in 117 workers from two representative fitness equipment manufacturing plants. MDA levels varied according to workers' roles at the manufacturing plants, and showed a trend as cutting>painting>welding> administration workers. Welders had marginally shorter average telomere lengths than the administrative workers (p=0.058). Cr and Mn levels were significantly greater in welders than they were in administrative workers. There were significantly positive correlations between MDA and Cr and Mn levels, the major components of welding fume. However, the association would be eliminated if co-metals exposure were considered simultaneously. In future, telomere length and MDA might be potential biomarkers for predicting cardiovascular disease in co-metals exposed workers. Key words: Telomere length, Welding, Metals, Oxidative damage, MDA |
| Audience | Academic |
| Author | KO, Jiunn-Liang CHENG, Yu-Jung HSIN, I-Lun LIU, Guan-Cen CHEN, Hsiu-Ling |
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| Keywords | MDA Telomere length Welding Oxidative damage Metals |
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| References_xml | – reference: 35) Furumoto K, Inoue E, Nagao N, Hiyama E, Miwa N (1998) Age-dependent telomere shortening is slowed down by enrichment of intracellular vitamin C via suppression of oxidative stress. Life Sci 63, 935–48. – reference: 7) Proctor CJ, Kirkwood TBL (2002) Modelling telomere shortening and the role of oxidative stress. Mech Ageing Dev 123, 351–63. – reference: 10) Richter T, von Zglinicki T (2007) A continuous correlation between oxidative stress and telomere shortening in fibroblasts. Exp Gerontol 42, 1039–42. – reference: 26) Chuang CH, Huang CE, Chen HL (2010) DNA strand breakage and lipid peroxidation after exposure to welding fumes in vivo. Mutagenesis 25, 71–6. – reference: 25) Antonini JM, Leonard SS, Roberts JR, Solano-Lopez C, Young SH, Shi X, Taylor MD (2005) Effect of stainless steel manual metal arc welding fume on free radical production, DNA damage, and apoptosis induction. 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| Snippet | The welding is the major working process in fitness equipment manufacturing industry, and International Agency for Research on Cancer has classified welding... The welding is the major working process in fitness equipment manufacturing industry, and International Agency for Research on Cancer has classifed welding... |
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| SubjectTerms | Adult Air Pollutants, Occupational - analysis Bioassays Biomarkers Biomarkers - analysis Cancer Carcinogens Cardiovascular diseases Chemical properties Chromium Chromosomes Comet assay Damage assessment Damage detection Degassing of metals DNA Damage Exercise equipment Exercise equipment industry Exposure Female Fitness Fitness equipment Fumes Health aspects Humans Industrial engineering Industrial plants Male Malondialdehyde Malondialdehyde - blood Manufacturing Manufacturing engineering Manufacturing industry Materials MDA Metal concentrations Metal workers Metals Metals, Heavy - blood Occupational exposure Occupational Exposure - analysis Occupational health Occupational health and safety Original Oxidative damage Oxidative Stress Risk factors Sporting goods Taiwan - epidemiology Telomere length Telomere Shortening Telomeres Toxicity Welding Welding fumes Welding machines |
| Title | The association of occupational metals exposure and oxidative damage, telomere shortening in fitness equipments manufacturing workers |
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