FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise

• Published in: Metabolism, clinical and experimental Vol. 61; no. 12; pp. 1725 - 1738
• Main Authors: Huh, Joo Young, Panagiotou, Grigorios, Mougios, Vassilis, Brinkoetter, Mary, Vamvini, Maria T., Schneider, Benjamin E., Mantzoros, Christos S.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.12.2012; Elsevier
• Subjects: adenosine triphosphate; Adenosine Triphosphate - blood; Adiponectin; Adult; Age; Athletes; ATP; Bariatric Surgery; Biological and medical sciences; Biomarkers - blood; blood serum; Body mass; Body Mass Index; Cholesterol; correlation; Cross-Sectional Studies; Endocrinology & Metabolism; Exercise; Feeding. Feeding behavior; Female; Fibronectins - blood; Fibronectins - genetics; Fibronectins - metabolism; FNDC5; Fundamental and applied biological sciences. Psychology; Gene expression; Gene Expression Regulation; genes; ghrelin; Glucose; Glycolysis; Hormones; Hormones - blood; Humans; Insulin; Insulin-like growth factor I; Irisin; Lipolysis; Male; males; Membrane proteins; messenger RNA; Metabolism; Metabolites; mice; Middle Aged; middle-aged adults; mRNA; muscle tissues; Muscles; Obesity; Obesity, Morbid - blood; Obesity, Morbid - surgery; Physical training; physiological regulation; Regression analysis; RNA, Messenger - blood; Running; subcutaneous fat; Surgery; tissue distribution; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Weight Loss; women; WHR; FNDC5; GH; Irisin; PGC1-α; Exercise; IGFBP-3; Weight loss; UCP1; IGF-1; PPARγ; BMI; body mass index; waist-to-hip ratio; uncoupling protein 1; insulin-like growth factor binding protein 3; PPARγ coactivator 1 alpha; growth hormone; insulin-like growth factor 1; peroxisome proliferator-activated receptor gamma; Physical exercise; Human; Messenger RNA; Prediction; Serum; Concentration; Gene expression; Endocrinology; Blood plasma

In mouse, PGC1-α overexpression in muscle stimulates an increase in expression of FNDC5, a membrane protein that is cleaved and secreted as a newly identified hormone, irisin. One prior study has shown that FNDC5 induces browning of subcutaneous fat in mice and mediates beneficial effects of exercis...