Ebola virus requires a host scramblase for externalization of phosphatidylserine on the surface of viral particles

• Published in: PLoS pathogens Vol. 14; no. 1; p. e1006848
• Main Authors: Nanbo, Asuka, Maruyama, Junki, Imai, Masaki, Ujie, Michiko, Fujioka, Yoichiro, Nishide, Shinya, Takada, Ayato, Ohba, Yusuke, Kawaoka, Yoshihiro
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.01.2018; Public Library of Science (PLoS)
• Subjects: Analysis; Animals; Apoptosis; Biology and life sciences; Budding; Caspase; Cell surface; Cercopithecus aethiops; Ebola virus; Ebolavirus; Ebolavirus - physiology; Endoplasmic reticulum; Epidemics; Epidemiology; Exposure; Funding; Glycoproteins; HEK293 Cells; Hemorrhagic Fever, Ebola - metabolism; Hemorrhagic Fever, Ebola - virology; Host-Pathogen Interactions; Host-virus relationships; Humans; Immunology; Infections; Infectious diseases; Internalization; Intracellular; Life sciences; Matrix protein; Medicine; Medicine and Health Sciences; Membrane vesicles; Membranes; Phosphatidylserine; Phosphatidylserines; Phosphatidylserines - metabolism; Phospholipid Transfer Proteins - physiology; Physiology; Plasma; Progeny; Proteins; R&D; Receptors; Research & development; Research and Analysis Methods; Vero Cells; Vesicles; Viral Core Proteins - metabolism; Virion - metabolism; Virions; Virology; Virus Release; Viruses; VP40 protein; Zoonoses; Japan

Cell surface receptors for phosphatidylserine contribute to the entry of Ebola virus (EBOV) particles, indicating that the presence of phosphatidylserine in the envelope of EBOV is important for the internalization of EBOV particles. Phosphatidylserine is typically distributed in the inner layer of...