Autophagy and multidrug resistance in cancer

• Published in: Ai zheng Vol. 36; no. 8; pp. 342 - 351
• Main Authors: Li, Ying‐Jie, Lei, Yu‐He, Yao, Nan, Wang, Chen‐Ran, Hu, Nan, Ye, Wen‐Cai, Zhang, Dong‐Mei, Chen, Zhe‐Sheng
• Format: Journal Article
• Language: English
• Published: London BioMed Central 24.06.2017; BioMed Central Ltd; John Wiley & Sons, Inc; Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, Guangdong, P.R.China%Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, Guangdong, P.R.China; Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St.John's University, Queens, NY 11439, USA; BMC
• Subjects: Amino acids; Antineoplastic Agents - therapeutic use; Apoptosis; Apoptosis - drug effects; Autophagy; Autophagy (Cytology); Autophagy - drug effects; Autophagy - genetics; Autophagy;Drug; Cancer; Cancer therapies; Care and treatment; Cell death; Cell growth; Cell survival; Chemotherapy; death; Diagnosis; Drug resistance; Drug resistance in microorganisms; Drug Resistance, Multiple - genetics; Drug Resistance, Neoplasm - genetics; Endoplasmic reticulum; Enzymes; Fatty acids; Homeostasis; Humans; Hypoxia; Kinases; Lung cancer; Multidrug resistant organisms; Nanoparticles; Neoplasms; Neoplasms - drug therapy; Neoplasms - genetics; Neoplasms - pathology; Ovarian cancer; Proteins; Recycling; resistance;Neoplasms;Cell; Review; survival;Cell; Cell survival; Drug resistance; Cell death; Autophagy; Neoplasms

Multidrug resistance (MDR) occurs frequently after long-term chemotherapy, resulting in refractory cancer and tumor recurrence. Therefore, combatting MDR is an important issue. Autophagy, a self-degradative system, universally arises during the treatment of sensitive and MDR cancer. Autophagy can be...