ZEB1 insufficiency causes corneal endothelial cell state transition and altered cellular processing

• Published in: PloS one Vol. 14; no. 6; p. e0218279
• Main Authors: Frausto, Ricardo F, Chung, Doug D, Boere, Payton M, Swamy, Vinay S, Duong, Huong N V, Kao, Liyo, Azimov, Rustam, Zhang, Wenlin, Carrigan, Liam, Wong, Davey, Morselli, Marco, Zakharevich, Marina, Hanser, E Maryam, Kassels, Austin C, Kurtz, Ira, Pellegrini, Matteo, Aldave, Anthony J
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 13.06.2019; Public Library of Science (PLoS)
• Subjects: Apoptosis; BASIC BIOLOGICAL SCIENCES; Biology and Life Sciences; Cadherins; Cadherins - metabolism; Cell adhesion & migration; Cell cycle; Cell Line, Tumor; Cell lineage; Cell Proliferation; Cornea; Cornea - metabolism; Corneal diseases; Corneal Dystrophies, Hereditary - genetics; Corneal Dystrophies, Hereditary - metabolism; Corneal dystrophy; CRISPR; CRISPR-Cas technology; Developmental biology; DNA binding proteins; Dystrophy; Endothelial cells; Endothelial Cells - metabolism; Endothelium; Endothelium, Corneal - metabolism; Epithelial-Mesenchymal Transition - physiology; Gene expression; Gene Expression Regulation - genetics; Genomics; Homeobox; Homeodomain Proteins - genetics; Humans; Medicine; Medicine and Health Sciences; Mesenchyme; Mutation; Nephrology; Phenotypes; Research and Analysis Methods; Science & Technology - Other Topics; Stem cells; Transcription factors; Transcription Factors - metabolism; Transcriptome; Wound care; Wound healing; Zinc; Zinc Finger E-box-Binding Homeobox 1 - genetics; Zinc Finger E-box-Binding Homeobox 1 - metabolism; Zinc finger proteins; Los Angeles California; United States > US; California

The zinc finger e-box binding homeobox 1 (ZEB1) transcription factor is a master regulator of the epithelial to mesenchymal transition (EMT), and of the reverse mesenchymal to epithelial transition (MET) processes. ZEB1 plays an integral role in mediating cell state transitions during cell lineage s...