Negative selection in tumor genome evolution acts on essential cellular functions and the immunopeptidome

• Published in: Genome Biology Vol. 19; no. 1; p. 67
• Main Authors: Zapata, Luis, Pich, Oriol, Serrano, Luis, Kondrashov, Fyodor A., Ossowski, Stephan, Schaefer, Martin H.
• Format: Journal Article
• Language: English
• Published: England BioMed Central 31.05.2018; BMC
• Subjects: Acids; Antigens, Neoplasm - immunology; Antitumor activity; Bias; Bioinformatics; Cancer; Cancer immunology; Cancer-essential genes; Cell cycle; Consortia; Epitopes; Exome; Genes; Genes, Neoplasm; Genetic transformation; Genome; Genomes; Genomics; glucose; Glucose metabolism; Glucose transport; Humans; Immune response; Immunosurveillance; monitoring; Mutation; Natural selection; Negative selection; Neoepitopes; neoplasms; Neoplasms - genetics; Neoplasms - immunology; patients; peptides; Peptides - immunology; Positive selection; Protein biosynthesis; protein synthesis; Protein turnover; Proteins; Selection, Genetic; Tumor evolution; Cancer immunology; Tumor evolution; Cancer-essential genes; Negative selection; Neoepitopes

Natural selection shapes cancer genomes. Previous studies used signatures of positive selection to identify genes driving malignant transformation. However, the contribution of negative selection against somatic mutations that affect essential tumor functions or specific domains remains a controvers...