Spindle Multipolarity Is Prevented by Centrosomal Clustering
Most tumor cells are characterized by increased genomic instability and chromosome segregational defects, often associated with hyperamplification of the centrosome and the formation of multipolar spindles. However, extra centrosomes do not always lead to multipolarity. Here, we describe a process o...
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| Published in | Science (American Association for the Advancement of Science) Vol. 307; no. 5706; pp. 127 - 129 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Washington, DC
American Association for the Advancement of Science
07.01.2005
The American Association for the Advancement of Science |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Most tumor cells are characterized by increased genomic instability and chromosome segregational defects, often associated with hyperamplification of the centrosome and the formation of multipolar spindles. However, extra centrosomes do not always lead to multipolarity. Here, we describe a process of centrosomal clustering that prevented the formation of multipolar spindles in noncancer cells. Noncancer cells needed to overcome this clustering mechanism to allow multipolar spindles to form at a high frequency. The microtubule motor cytoplasmic dynein was a critical part of this coalescing machinery, and in some tumor cells overexpression of the spindle protein NuMA interfered with dynein localization, promoting multipolarity. |
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| AbstractList | Most tumor cells are characterized by increased genomic instability and chromosome segregational defects, often associated with hyperamplification of the centrosome and the formation of multipolar spindles. However, extra centrosomes do not always lead to multipoiarity. Here, we describe a process of centrosomal clustering that prevented the formation of multipolar spindles in noncancer cells. Noncancer cells needed to overcome this clustering mechanism to allow multipolar spindles to form at a high frequency. The microtubule motor cytoplasmic dynein was a critical part of this coalescing machinery, and in some tumor cells overexpression of the spindle protein NuMA interfered with dynein localization, promoting multipoiarity. Most tumor cells are characterized by increased genomic instability and chromosome segregational defects, often associated with hyperamplification of the centrosome and the formation of multipolar spindles. However, extra centrosomes do not always lead to multipolarity. Here, we describe a process of centrosomal clustering that prevented the formation of multipolar spindles in noncancer ceils. Noncancer cells needed to overcome this clustering mechanism to allow multipolar spindles to form at a high frequency. The microtubule motor cytoplasmic dynein was a critical part of this coalescing machinery, and in some tumor cells overexpression of the spindle protein NuMA interfered with dynein Localization, promoting multipolarity. Most tumor cells are characterized by increased genomic instability and chromosome segregational defects, often associated with hyperamplification of the centrosome and the formation of multipolar spindles. However, extra centrosomes do not always lead to multipolarity. Here, we describe a process of centrosomal clustering that prevented the formation of multipolar spindles in noncancer cells. Noncancer cells needed to overcome this clustering mechanism to allow multipolar spindles to form at a high frequency. The microtubule motor cytoplasmic dynein was a critical part of this coalescing machinery, and in some tumor cells overexpression of the spindle protein NuMA interfered with dynein localization, promoting multipolarity. Most tumor cells are characterized by increased genomic instability and chromosome segregational defects, often associated with hyperamplification of the centrosome and the formation of multipolar spindles. However, extra centrosomes do not always lead to multipolarity. Here, we describe a process of centrosomal clustering that prevented the formation of multipolar spindles in noncancer cells. Noncancer cells needed to overcome this clustering mechanism to allow multipolar spindles to form at a high frequency. The microtubule motor cytoplasmic dynein was a critical part of this coalescing machinery, and in some tumor cells overexpression of the spindle protein NuMA interfered with dynein localization, promoting multipolarity. [PUBLICATION ABSTRACT] |
| Audience | Academic |
| Author | Hoffelder, Diane R Gollin, Susanne M Quintyne, Nicholas J Reing, Janet E Saunders, William S |
| Author_xml | – sequence: 1 fullname: Quintyne, Nicholas J – sequence: 2 fullname: Reing, Janet E – sequence: 3 fullname: Hoffelder, Diane R – sequence: 4 fullname: Gollin, Susanne M – sequence: 5 fullname: Saunders, William S |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16472157$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/15637283$$D View this record in MEDLINE/PubMed |
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| CODEN | SCIEAS |
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| ContentType | Journal Article |
| Copyright | Copyright 2005 American Association for the Advancement of Science 2005 INIST-CNRS COPYRIGHT 2005 American Association for the Advancement of Science COPYRIGHT 2005 American Association for the Advancement of Science Copyright American Association for the Advancement of Science Jan 7, 2005 |
| Copyright_xml | – notice: Copyright 2005 American Association for the Advancement of Science – notice: 2005 INIST-CNRS – notice: COPYRIGHT 2005 American Association for the Advancement of Science – notice: COPYRIGHT 2005 American Association for the Advancement of Science – notice: Copyright American Association for the Advancement of Science Jan 7, 2005 |
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| DOI | 10.1126/science.1104905 |
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| SubjectTerms | Antibodies Antigens, Nuclear Biological and medical sciences Cancer Cell Line Cell Line, Tumor Cell lines Cells Centrosome Centrosome - physiology Centrosomes Chromosomes Demecolcine - pharmacology Dynactin Complex Dyneins - metabolism Fundamental and applied biological sciences. Psychology Genomics HEK293 cells Humans Medical research Metaphase Microtubule-Associated Proteins - metabolism Mitosis Mitotic spindle apparatus Molecular and cellular biology Mouth neoplasms Nuclear Matrix-Associated Proteins Nuclear Proteins - genetics Nuclear Proteins - metabolism Plasmids Proteins RNA, Small Interfering - metabolism Small interfering RNA Spindle Apparatus - physiology Transfection Tumor cell line Tumors |
| Title | Spindle Multipolarity Is Prevented by Centrosomal Clustering |
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