Antisense Transcription in the Mammalian Transcriptome

• Published in: Science (American Association for the Advancement of Science) Vol. 309; no. 5740; pp. 1564 - 1566
• Main Authors: Katayama, S, Tomaru, Y, Kasukawa, T, Waki, K, Nakanishi, M, Nakamura, M, Nishida, H, Yap, C. C, Suzuki, M, Kawai, J, Suzuki, H, Carninci, P, Hayashizaki, Y, Wells, C, Frith, M, Ravasi, T, Pang, K. C, Hallinan, J, Mattick, J, Hume, D. A, Lipovich, L, Batalov, S, Engström, P. G, Mizuno, Y, Faghihi, M. A, Sandelin, A, Chalk, A. M, Mottagui-Tabar, S, Liang, Z, Lenhard, B, Wahlestedt, C
• Format: Journal Article
• Language: English
• Published: Washington, DC American Association for the Advancement of Science 02.09.2005; The American Association for the Advancement of Science
• Subjects: Animals; Antisense DNA; Biological and medical sciences; Chromatin; Coding; Complementary DNA; Disproportionate Representation; Evidence; Fundamental and applied biological sciences. Psychology; Gene Expression Regulation; Gene loci; Genetic loci; Genetic transcription; Genome; Genomes; Humans; Libraries; Mammals; Medical research; Medicin och hälsovetenskap; Messenger RNA; Mice - genetics; Molecular and cellular biology; Molecular genetics; Proteins; Research facilities; Ribonucleic acid; RNA; RNA Interference; RNA, Antisense - biosynthesis; RNA, Messenger - biosynthesis; Small interfering RNA; Transcription (Genetics); Transcription, Genetic; Transcription. Transcription factor. Splicing. Rna processing; Transcriptomes; Transcripts (Written Records); Gene silencing; Chromatin; Regulation(control); RNA interference; Transcription; transcriptome; Chromosome; Antisense RNA; Gene expression; Genome

Antisense transcription (transcription from the opposite strand to a protein-coding or sense strand) has been ascribed roles in gene regulation involving degradation of the corresponding sense transcripts (RNA interference), as well as gene silencing at the chromatin level. Global transcriptome anal...