Low Copy Number of the AMY1 Locus Is Associated with Early-Onset Female Obesity in Finland

• Published in: PloS one Vol. 10; no. 7; p. e0131883
• Main Authors: Viljakainen, Heli, Andersson-Assarsson, Johanna C, Armenio, Miriam, Pekkinen, Minna, Pettersson, Maria, Valta, Helena, Lipsanen-Nyman, Marita, Mäkitie, Outi, Lindstrand, Anna
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.07.2015; Public Library of Science (PLoS)
• Subjects: Adolescent; Adult; Amylases; Anthropometry; Body Composition - genetics; Body fat; Body mass; Cardiology and Cardiovascular Disease; Children; Copy number; DNA Copy Number Variations; DNA methylation; DNA-Binding Proteins - genetics; Female; Females; Finland; FRAMESHIFT MUTATION; Gender aspects; GENE; Gene Dosage; Genetic Association Studies; Genetic Load; Genetic Predisposition to Disease; GENOME; Glucose; HUMANS; INSULIN-RESISTANCE; Kardiologi och kardiovaskulära sjukdomar; Loci; Male; Males; MC4R; Multidisciplinary Sciences; Obesity; Obesity - genetics; RISK; Sex differences; Sex Factors; Studies; Subgroups; Transcription Factors - genetics; US ADOLESCENTS; Young Adult; α-Amylase; Finland
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0131883

The salivary α-amylase locus (AMY1) is located in a highly polymorphic multi allelic copy number variable chromosomal region. A recent report identified an association between AMY1 copy numbers and BMI in common obesity. The present study investigated the relationship between AMY1 copy number, BMI a...