Complicated postoperative recovery increases omission, delay and discontinuation of adjuvant chemotherapy in patients with S tage III colon cancer
Abstract Aim The study included investigation of factors determining suboptimal adjuvant chemotherapy of patients diagnosed with S tage III colon cancer. Method All 606 patients diagnosed with S tage III colon cancer between 2006 and 2008 in the western part of the N etherlands were included. Patien...
Saved in:
Published in | Colorectal disease Vol. 15; no. 10 |
---|---|
Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
01.10.2013
|
Online Access | Get full text |
Cover
Loading…
Abstract | Abstract
Aim
The study included investigation of factors determining suboptimal adjuvant chemotherapy of patients diagnosed with
S
tage
III
colon cancer.
Method
All 606 patients diagnosed with
S
tage
III
colon cancer between 2006 and 2008 in the western part of the
N
etherlands were included. Patient [gender, age, comorbidity and socio‐economic status (
SES
)], tumour (location, stage and grade) and treatment (emergency surgery, laparoscopic surgery, reoperation, hospital stay and multidisciplinary meeting) factors were examined in logistic regression analyses predicting a complicated postoperative period and omission, delay and discontinuation of adjuvant chemotherapy.
Results
Overall, 27% of all patients experienced a complicated postoperative period, which was independently associated with emergency surgery, older age, multiple comorbidity, male gender and poor tumour grade. Of patients who survived this period, 60% received chemotherapy. Chemotherapy was omitted more often in women, the elderly and in patients with
S
tage
IIIB
, reoperation, prolonged hospital stay and (borderline) after open surgery. Of patients who received chemotherapy, 86% started within 8 weeks after surgery. Patients with a higher
SES
, reoperation and prolonged hospital stay had a higher probability of a delayed start. Sixty‐seven per cent of patients completed their chemotherapy. For women, elderly patients and patients with prolonged hospital stay a higher probability of discontinuation was noted.
Conclusion
Age was the most important predictive factor for receiving adjuvant chemotherapy. However, at all ages, complicated postoperative recovery negatively influenced the administration of chemotherapy to
S
tage
III
colon cancer patients, as well as a timely start and completion of chemotherapy. |
---|---|
AbstractList | Abstract
Aim
The study included investigation of factors determining suboptimal adjuvant chemotherapy of patients diagnosed with
S
tage
III
colon cancer.
Method
All 606 patients diagnosed with
S
tage
III
colon cancer between 2006 and 2008 in the western part of the
N
etherlands were included. Patient [gender, age, comorbidity and socio‐economic status (
SES
)], tumour (location, stage and grade) and treatment (emergency surgery, laparoscopic surgery, reoperation, hospital stay and multidisciplinary meeting) factors were examined in logistic regression analyses predicting a complicated postoperative period and omission, delay and discontinuation of adjuvant chemotherapy.
Results
Overall, 27% of all patients experienced a complicated postoperative period, which was independently associated with emergency surgery, older age, multiple comorbidity, male gender and poor tumour grade. Of patients who survived this period, 60% received chemotherapy. Chemotherapy was omitted more often in women, the elderly and in patients with
S
tage
IIIB
, reoperation, prolonged hospital stay and (borderline) after open surgery. Of patients who received chemotherapy, 86% started within 8 weeks after surgery. Patients with a higher
SES
, reoperation and prolonged hospital stay had a higher probability of a delayed start. Sixty‐seven per cent of patients completed their chemotherapy. For women, elderly patients and patients with prolonged hospital stay a higher probability of discontinuation was noted.
Conclusion
Age was the most important predictive factor for receiving adjuvant chemotherapy. However, at all ages, complicated postoperative recovery negatively influenced the administration of chemotherapy to
S
tage
III
colon cancer patients, as well as a timely start and completion of chemotherapy. |
Author | Tollenaar, R. A. E. M. Wouters, M. W. J. M. Struikmans, H. Portielje, J. E. A. van der Geest, L. G. M. Tanis, B. C. Nortier, J. W. R. Weijl, N. I. |
Author_xml | – sequence: 1 givenname: L. G. M. surname: van der Geest fullname: van der Geest, L. G. M. organization: Comprehensive Cancer Centre The Netherlands (CCCNL) Utrecht The Netherlands – sequence: 2 givenname: J. E. A. surname: Portielje fullname: Portielje, J. E. A. organization: Department of Internal Medicine Haga Hospital The Hague The Netherlands – sequence: 3 givenname: M. W. J. M. surname: Wouters fullname: Wouters, M. W. J. M. organization: Department of Surgery Leiden University Medical Centre Leiden The Netherlands – sequence: 4 givenname: N. I. surname: Weijl fullname: Weijl, N. I. organization: Department of Internal Medicine Bronovo Hospital The Hague The Netherlands – sequence: 5 givenname: B. C. surname: Tanis fullname: Tanis, B. C. organization: Department of Internal Medicine Groene Hart Hospital Gouda The Netherlands – sequence: 6 givenname: R. A. E. M. surname: Tollenaar fullname: Tollenaar, R. A. E. M. organization: Department of Surgery Leiden University Medical Centre Leiden The Netherlands – sequence: 7 givenname: H. surname: Struikmans fullname: Struikmans, H. organization: Radiotherapy Centre West The Hague The Netherlands – sequence: 8 givenname: J. W. R. surname: Nortier fullname: Nortier, J. W. R. organization: Department of Clinical Oncology Leiden University Medical Centre Leiden The Netherlands |
BookMark | eNotkMtOwzAQRS1UJNrChi-YNSIlztNZoopHpEos6D5yxhPqKrEj2y3qb_DFpIW7mbuYexZnwWbGGmLsnscrPuUJrdIrniRCXLE5z4o04ikXs0tPIlHx-IYtvN_HMS9KLubsZ22HsdcoAykYrQ92JCeDPhI4QnskdwJt0JH05MEO2nttzSMo6uUJpFGgtEdrgjaHaWYN2A6k2h-O0gTAHQ027CbieMbAOL2QCR6-ddjBJwT5RVDXNaDtpylKg-Ru2XUne093_3fJtq8v2_V7tPl4q9fPmwjLQkQdZpSrpMha7JTEjoqWRFEJTqolWcqqjPO87PI2pgqzElOZtbLiqlUZV1VVpUv28IdFZ7131DWj04N0p4bHzVlmc5bZXGSmvxQqb0k |
CitedBy_id | crossref_primary_10_1097_SLA_0000000000000859 crossref_primary_10_1016_j_amjsurg_2020_02_015 crossref_primary_10_1097_AS9_0000000000000267 crossref_primary_10_1002_ijc_33806 crossref_primary_10_1016_j_clcc_2022_07_004 crossref_primary_10_1245_s10434_017_6142_6 crossref_primary_10_1245_s10434_015_5073_3 crossref_primary_10_1186_s12885_022_09767_y crossref_primary_10_1245_s10434_014_3664_z crossref_primary_10_1080_0284186X_2020_1772501 crossref_primary_10_5534_wjmh_230335 crossref_primary_10_1007_s11605_021_05129_4 crossref_primary_10_1111_codi_12437 crossref_primary_10_1200_JCO_21_02726 crossref_primary_10_1245_s10434_016_5226_z crossref_primary_10_1111_bcp_15300 crossref_primary_10_1007_s00228_022_03298_y crossref_primary_10_1016_j_dld_2017_05_017 crossref_primary_10_3748_wjg_v21_i17_5167 crossref_primary_10_1016_j_ejso_2019_10_038 crossref_primary_10_1007_s00384_020_03550_w crossref_primary_10_1200_CCI_20_00065 crossref_primary_10_1177_1758835920986520 crossref_primary_10_3393_ac_2014_30_6_274 crossref_primary_10_1053_j_scrs_2014_04_006 crossref_primary_10_3390_cancers14010148 crossref_primary_10_1002_cam4_2843 crossref_primary_10_1016_j_urolonc_2019_11_001 crossref_primary_10_1016_j_jinf_2014_10_008 crossref_primary_10_1002_cam4_921 crossref_primary_10_1016_j_ejca_2015_04_004 crossref_primary_10_1007_s12664_015_0579_y crossref_primary_10_1016_j_ejso_2018_01_079 crossref_primary_10_1111_codi_13308 crossref_primary_10_1111_codi_14999 crossref_primary_10_4236_jct_2019_101004 crossref_primary_10_1016_j_clnu_2022_05_016 crossref_primary_10_1111_codi_14525 crossref_primary_10_1007_s10147_024_02567_3 crossref_primary_10_1111_codi_16661 crossref_primary_10_1016_j_soc_2013_09_009 crossref_primary_10_1177_17588359211006348 crossref_primary_10_5534_wjmh_230085 crossref_primary_10_1016_j_ejca_2015_08_016 crossref_primary_10_1002_jso_24017 crossref_primary_10_1016_j_ejso_2015_09_009 crossref_primary_10_1007_s11605_023_05748_z crossref_primary_10_1245_s10434_015_4479_2 crossref_primary_10_3393_ac_2014_30_6_250 crossref_primary_10_1097_DCR_0000000000001486 |
Cites_doi | 10.1007/DCR.0b013e3181f2f202 10.1245/s10434-011-1671-x 10.1200/JCO.2005.04.5005 10.1001/jama.2011.749 10.1093/annonc/mdl029 10.1093/ije/22.3.369 10.1245/s10434-010-1479-0 10.1016/j.ctrv.2009.04.003 10.1016/j.amjsurg.2011.11.015 10.1111/j.1532-5415.2011.03334.x 10.3109/02841861003782009 10.1186/1471‐2482‐12‐S1‐S8 10.1111/j.1463-1318.2011.02804.x 10.1001/jama.2010.272 10.1016/S0140-6736(02)09290-5 10.1001/archsurg.142.3.298 10.1002/cncr.23958 10.1056/NEJMoa010957 10.1016/0021-9681(87)90171-8 10.1007/DCR.0b013e3181a51173 10.1002/cncr.22316 10.1007/DCR.0b013e3181e78815 10.1002/ijc.26192 10.1093/annonc/mdq227 10.1200/JCO.1998.16.4.1582 |
ContentType | Journal Article |
CorporateAuthor | all nine hospitals in the Leiden region of the Comprehensive Cancer Centre The Netherlands (CCCNL) |
CorporateAuthor_xml | – name: all nine hospitals in the Leiden region of the Comprehensive Cancer Centre The Netherlands (CCCNL) |
DBID | AAYXX CITATION |
DOI | 10.1111/codi.12288 |
DatabaseName | CrossRef |
DatabaseTitle | CrossRef |
DatabaseTitleList | CrossRef |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine |
EISSN | 1463-1318 |
ExternalDocumentID | 10_1111_codi_12288 |
GroupedDBID | --- .3N .GA .Y3 05W 0R~ 10A 1OC 29F 31~ 33P 36B 3SF 4.4 50Y 50Z 51W 51X 52M 52N 52O 52P 52R 52S 52T 52U 52V 52W 52X 53G 5GY 5HH 5LA 5VS 66C 6J9 702 7PT 8-0 8-1 8-3 8-4 8-5 8UM 930 A01 A03 AAESR AAEVG AAHHS AANLZ AAONW AASGY AAXRX AAYXX AAZKR ABCQN ABCUV ABEML ABJNI ABPVW ABQWH ABXGK ACAHQ ACBWZ ACCFJ ACCZN ACGFO ACGFS ACGOF ACMXC ACPOU ACPRK ACSCC ACXBN ACXQS ADBBV ADBTR ADEOM ADIZJ ADKYN ADMGS ADOZA ADXAS ADZMN ADZOD AEEZP AEGXH AEIGN AEIMD AENEX AEQDE AEUQT AEUYR AFBPY AFEBI AFFPM AFGKR AFPWT AFRAH AFZJQ AHBTC AIACR AIAGR AITYG AIURR AIWBW AJBDE ALAGY ALMA_UNASSIGNED_HOLDINGS ALUQN AMBMR AMYDB ASPBG ATUGU AVWKF AZBYB AZFZN AZVAB BAFTC BDRZF BFHJK BHBCM BMXJE BROTX BRXPI BY8 C45 CAG CITATION COF CS3 D-6 D-7 D-E D-F DCZOG DPXWK DR2 DRFUL DRMAN DRSTM DU5 EBS EJD ESX EX3 F00 F01 F04 F5P FEDTE FUBAC G-S G.N GODZA H.X HF~ HGLYW HVGLF HZI HZ~ IHE IX1 J0M KBYEO LATKE LC2 LC3 LEEKS LH4 LITHE LOXES LP6 LP7 LUTES LW6 LYRES MEWTI MK4 MRFUL MRMAN MRSTM MSFUL MSMAN MSSTM MXFUL MXMAN MXSTM N04 N05 N9A NF~ O66 O9- OIG OVD P2P P2W P2X P2Z P4B P4D Q.N Q11 QB0 R.K ROL RX1 SUPJJ TEORI UB1 V8K V9Y W8V W99 WBKPD WHWMO WIH WIJ WIK WOHZO WOW WQJ WRC WVDHM WXI WXSBR XG1 YFH YUY ZZTAW ~IA ~WT |
ID | FETCH-LOGICAL-c768-fc4e5d264bcfdacfe6be86981edbea7a970557f5b0e9c47c3a4ba91dbd41d9993 |
ISSN | 1462-8910 |
IngestDate | Fri Aug 23 00:39:41 EDT 2024 |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 10 |
Language | English |
LinkModel | OpenURL |
MergedId | FETCHMERGED-LOGICAL-c768-fc4e5d264bcfdacfe6be86981edbea7a970557f5b0e9c47c3a4ba91dbd41d9993 |
ParticipantIDs | crossref_primary_10_1111_codi_12288 |
PublicationCentury | 2000 |
PublicationDate | 2013-10-00 |
PublicationDateYYYYMMDD | 2013-10-01 |
PublicationDate_xml | – month: 10 year: 2013 text: 2013-10-00 |
PublicationDecade | 2010 |
PublicationTitle | Colorectal disease |
PublicationYear | 2013 |
References | e_1_2_10_23_1 e_1_2_10_24_1 e_1_2_10_21_1 e_1_2_10_20_1 e_1_2_10_2_1 e_1_2_10_4_1 e_1_2_10_18_1 e_1_2_10_3_1 e_1_2_10_19_1 e_1_2_10_6_1 e_1_2_10_16_1 e_1_2_10_5_1 e_1_2_10_17_1 e_1_2_10_8_1 e_1_2_10_14_1 e_1_2_10_7_1 e_1_2_10_15_1 e_1_2_10_12_1 e_1_2_10_9_1 e_1_2_10_13_1 e_1_2_10_30_1 Wittekind C (e_1_2_10_11_1) 2004 Fritz A (e_1_2_10_10_1) 2000 Schwenk W (e_1_2_10_22_1) 2005 e_1_2_10_29_1 e_1_2_10_27_1 e_1_2_10_28_1 e_1_2_10_25_1 e_1_2_10_26_1 |
References_xml | – ident: e_1_2_10_6_1 doi: 10.1007/DCR.0b013e3181f2f202 – ident: e_1_2_10_29_1 doi: 10.1245/s10434-011-1671-x – start-page: CD003145 issue: 3 year: 2005 ident: e_1_2_10_22_1 article-title: Short term benefits for laparoscopic colorectal resection publication-title: Cochrane Database Syst Rev contributor: fullname: Schwenk W – ident: e_1_2_10_8_1 doi: 10.1200/JCO.2005.04.5005 – ident: e_1_2_10_7_1 doi: 10.1001/jama.2011.749 – volume-title: TNM atlas year: 2004 ident: e_1_2_10_11_1 contributor: fullname: Wittekind C – ident: e_1_2_10_15_1 doi: 10.1093/annonc/mdl029 – ident: e_1_2_10_9_1 doi: 10.1093/ije/22.3.369 – ident: e_1_2_10_20_1 doi: 10.1245/s10434-010-1479-0 – ident: e_1_2_10_27_1 doi: 10.1016/j.ctrv.2009.04.003 – volume-title: International Classification of Diseases for Oncology (ICD‐O) year: 2000 ident: e_1_2_10_10_1 contributor: fullname: Fritz A – ident: e_1_2_10_19_1 doi: 10.1016/j.amjsurg.2011.11.015 – ident: e_1_2_10_25_1 doi: 10.1111/j.1532-5415.2011.03334.x – ident: e_1_2_10_4_1 doi: 10.3109/02841861003782009 – ident: e_1_2_10_21_1 doi: 10.1186/1471‐2482‐12‐S1‐S8 – ident: e_1_2_10_18_1 doi: 10.1111/j.1463-1318.2011.02804.x – ident: e_1_2_10_30_1 doi: 10.1001/jama.2010.272 – ident: e_1_2_10_23_1 doi: 10.1016/S0140-6736(02)09290-5 – ident: e_1_2_10_24_1 doi: 10.1001/archsurg.142.3.298 – ident: e_1_2_10_5_1 doi: 10.1002/cncr.23958 – ident: e_1_2_10_28_1 doi: 10.1056/NEJMoa010957 – ident: e_1_2_10_12_1 doi: 10.1016/0021-9681(87)90171-8 – ident: e_1_2_10_14_1 – ident: e_1_2_10_13_1 doi: 10.1007/DCR.0b013e3181a51173 – ident: e_1_2_10_17_1 doi: 10.1002/cncr.22316 – ident: e_1_2_10_16_1 doi: 10.1007/DCR.0b013e3181e78815 – ident: e_1_2_10_2_1 doi: 10.1002/ijc.26192 – ident: e_1_2_10_3_1 doi: 10.1093/annonc/mdq227 – ident: e_1_2_10_26_1 doi: 10.1200/JCO.1998.16.4.1582 |
SSID | ssj0016718 |
Score | 2.0558293 |
Snippet | Abstract
Aim
The study included investigation of factors determining suboptimal adjuvant chemotherapy of patients diagnosed with
S
tage
III
colon cancer.... |
SourceID | crossref |
SourceType | Aggregation Database |
Title | Complicated postoperative recovery increases omission, delay and discontinuation of adjuvant chemotherapy in patients with S tage III colon cancer |
Volume | 15 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9NAEF6FIiEuiKd4ayS4Ga_8WL-OVSltEOFAg9JbtC9LiSCOwLnwM_gZ_Epm7F3HbREqXKxos2snni_jmck33zL2ujSZLoTG7ETqKkSHJ0MZ4e8qM2Wm8hphHVE38uxjfvpZvD_PzieTXyPW0q5VXP_4Y1_J_1gVx9Cu1CX7D5YdTooD-Brti0e0MB6vZeMjzwfHqHFLChlb64S8Kc_Fr0NNfRQWfidpWbQolcboppI0ZC-8RF25De0WsRtiR2nWO4yv2wDt-dU1aHXdgU6D1TXEnQUt8X2m02lAytcb4o9px_X10gc4Th716h9B1DVFKhYn1vZNJx94cMKDGR9cNaYFK_tl3Zf4eXDMg8PhzUVDG1H0dXIeLDhN2C9d2NW6J3rzYMrHZY14T5Dznljk6Korx3m1fgznpc5he_edjWEa_eWxoBuz4nGS9PsIXtTevvRMHJiKPkeitctu7Q12MymqjOijbz8NUmVxXnS15OFjOylcYo3trzsKfkZRzPwuu-PSDzjssXSPTezmPrs1cwSLB-znCFJwAVLgIQUDpMBD6g10gAIEFFwCFDQ1eEDBGFB4GvCAAgIUnAEBChBQ0AEKekA9ZPN3x_Oj09Bt2xFqzF3DWgubGYyzla6N1LXNlS3zqoytUVYWsiL9pqLOVGQrLQqdSqFkFRtlRGwwXUkfsYNNs7GPGaSJqVSUySKRWogoVaWRcaLj2AhTYiLxhL3yt3O57cVZllcN9vRas56x23sYPmcH7bedfYHxZqtedob-DafhhxU |
link.rule.ids | 315,786,790,27955,27956 |
linkProvider | Wiley-Blackwell |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Complicated+postoperative+recovery+increases+omission%2C+delay+and+discontinuation+of+adjuvant+chemotherapy+in+patients+with+S+tage+III+colon+cancer&rft.jtitle=Colorectal+disease&rft.au=van+der+Geest%2C+L.+G.+M.&rft.au=Portielje%2C+J.+E.+A.&rft.au=Wouters%2C+M.+W.+J.+M.&rft.au=Weijl%2C+N.+I.&rft.date=2013-10-01&rft.issn=1462-8910&rft.eissn=1463-1318&rft.volume=15&rft.issue=10&rft_id=info:doi/10.1111%2Fcodi.12288&rft.externalDBID=n%2Fa&rft.externalDocID=10_1111_codi_12288 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1462-8910&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1462-8910&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1462-8910&client=summon |