Genome-wide association identifies multiple ulcerative colitis susceptibility loci

• Published in: Nature genetics Vol. 42; no. 4; pp. 332 - 337
• Main Authors: McGovern, Dermot P B, Gardet, Agnès, Törkvist, Leif, Goyette, Philippe, Essers, Jonah, Taylor, Kent D, Neale, Benjamin M, Ong, Rick T H, Lagacé, Caroline, Li, Chun, Green, Todd, Stevens, Christine R, Beauchamp, Claudine, Fleshner, Phillip R, Carlson, Marie, D'Amato, Mauro, Halfvarson, Jonas, Hibberd, Martin L, Lördal, Mikael, Padyukov, Leonid, Andriulli, Angelo, Colombo, Elisabetta, Latiano, Anna, Palmieri, Orazio, Bernard, Edmond-Jean, Deslandres, Colette, Hommes, Daan W, de Jong, Dirk J, Stokkers, Pieter C, Weersma, Rinse K, Sharma, Yashoda, Silverberg, Mark S, Cho, Judy H, Wu, Jing, Roeder, Kathryn, Brant, Steven R, Schumm, L Phillip, Duerr, Richard H, Dubinsky, Marla C, Glazer, Nicole L, Haritunians, Talin, Ippoliti, Andy, Melmed, Gil Y, Siscovick, David S, Vasiliauskas, Eric A, Targan, Stephan R, Annese, Vito, Wijmenga, Cisca, Pettersson, Sven, Rotter, Jerome I, Xavier, Ramnik J, Daly, Mark J, Rioux, John D, Seielstad, Mark
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.04.2010; Nature Publishing Group
• Subjects: 631/208/205/2138; 631/208/727/2000; 692/699/1503/257/1389; Agriculture; Animal Genetics and Genomics; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Cancer Research; Colitis, Ulcerative - genetics; Development and progression; Disease susceptibility; Fundamental and applied biological sciences. Psychology; Gastroenterology. Liver. Pancreas. Abdomen; Gastrointestinal tract; Gene Function; Gene loci; Genetic aspects; Genetic diversity; Genetic Predisposition to Disease; Genetics of eukaryotes. Biological and molecular evolution; Genome-Wide Association Study; Human Genetics; Humans; Identification and classification; Inflammatory bowel disease; letter; Medical sciences; MEDICIN; MEDICINE; Membrane Proteins - genetics; Meta-analysis; Meta-Analysis as Topic; Other diseases. Semiology; Polymorphism, Single Nucleotide; Quantitative trait loci; Receptors, IgG - genetics; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Studies; Thermal cycling; Ulcerative colitis; Canada; Digestive diseases; Intestinal disease; Identification; Locus; Inflammatory disease; Ulcerative colitis

Mark Seielstad and colleagues report results of a large genome-wide association and replication study of ulcerative colitis. The work identifies several new risk loci for this disease and provides further insight into the shared pathogenesis of ulcerative colitis and Crohn's disease. Ulcerative...