A genetic association study of serum acute-phase C-reactive protein levels in rheumatoid arthritis: implications for clinical interpretation

• Published in: PLoS medicine Vol. 7; no. 9; p. e1000341
• Main Authors: Rhodes, Benjamin, Merriman, Marilyn E, Harrison, Andrew, Nissen, Michael J, Smith, Malcolm, Stamp, Lisa, Steer, Sophia, Merriman, Tony R, Vyse, Timothy J
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.09.2010; Public Library of Science (PLoS)
• Subjects: Arthritis, Rheumatoid - blood; Arthritis, Rheumatoid - diagnosis; Arthritis, Rheumatoid - genetics; Blood Sedimentation; C-reactive protein; C-Reactive Protein - genetics; C-Reactive Protein - metabolism; Diagnosis; Genetic aspects; Genetic Association Studies; Genetics and Genomics; Genetics and Genomics/Complex Traits; Genetics and Genomics/Genetics of the Immune System; Genotype; Haplotypes; Humans; Immunology/Genetics of the Immune System; Immunology/Immune Response; Immunology/Innate Immunity; Medical research; Physiological aspects; Polymorphism, Single Nucleotide; Proteins; Rheumatoid arthritis; Rheumatology/Imaging and Biomarkers; Rheumatology/Rheumatoid Arthritis; Single nucleotide polymorphisms; Studies; United Kingdom; Haplotypes; Blood Sedimentation; C-Reactive Protein; Genetic Association Studies; Humans; Genotype; Polymorphism, Single Nucleotide; Arthritis, Rheumatoid

The acute-phase increase in serum C-reactive protein (CRP) is used to diagnose and monitor infectious and inflammatory diseases. Little is known about the influence of genetics on acute-phase CRP, particularly in patients with chronic inflammation. We studied two independent sets of patients with ch...