Late responses to adenoviral-mediated transfer of the aquaporin-1 gene for radiation-induced salivary hypofunction

• Published in: Gene therapy Vol. 24; no. 3; pp. 176 - 186
• Main Authors: Alevizos, I, Zheng, C, Cotrim, A P, Liu, S, McCullagh, L, Billings, M E, Goldsmith, C M, Tandon, M, Helmerhorst, E J, Catalán, M A, Danielides, S J, Perez, P, Nikolov, N P, Chiorini, J A, Melvin, J E, Oppenheim, F G, Illei, G G, Baum, B J
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.03.2017; Nature Publishing Group
• Subjects: 13; 42; 631/1647/2300/1514; 631/61/201; 692/699/3020/3031; 692/699/67/1536; 82; Adenoviridae - genetics; Adenoviruses; Adrenal insufficiency; Adverse events; Aquaporin 1 - genetics; Aquaporin 1 - metabolism; Aquaporins; Biomedical and Life Sciences; Biomedicine; Biopsy; Care and treatment; Cell Biology; Cell membranes; Chlorides - metabolism; Diagnosis; Expression vectors; Gene Expression; Gene Therapy; Gene transfer; Genetic Therapy - adverse effects; Genetic transformation; Genetic Vectors - genetics; Head and neck cancer; Health aspects; Human Genetics; Humans; Laboratories; Methods; Middle Aged; Nanotechnology; original-article; Parotid gland; Proteins; Radiation; Radiotherapy - adverse effects; Risk factors; Saliva; Salivary diagnostics; Salivary gland diseases; Salivary Glands - metabolism; Sodium - metabolism; Testing; Vectors (Biology); Xerostomia - etiology; Xerostomia - therapy; United States
• ISSN: 0969-7128; 1476-5462; 1476-5462
• DOI: 10.1038/gt.2016.87

We evaluated late effects of AdhAQP1 administration in five subjects in a clinical trial for radiation-induced salivary hypofunction ( http://www.clinicaltrials.gov/ct/show/NCT00372320?order =). All were identified as initially responding to human aquaporin-1 (hAQP1) gene transfer. They were followe...