Genetic Variants Associated with Colorectal Adenoma Susceptibility

Common low-penetrance genetic variants have been consistently associated with colorectal cancer risk. To determine if these genetic variants are associated also with adenoma susceptibility and may improve selection of patients with increased risk for advanced adenomas and/or multiplicity (≥ 3 adenom...

Full description

Saved in:
Bibliographic Details
Published inPloS one Vol. 11; no. 4; p. e0153084
Main Authors Abulí, Anna, Castells, Antoni, Bujanda, Luis, Lozano, Juan José, Bessa, Xavier, Hernández, Cristina, Álvarez-Urturi, Cristina, Pellisé, Maria, Esteban-Jurado, Clara, Hijona, Elizabeth, Burón, Andrea, Macià, Francesc, Grau, Jaume, Guayta, Rafael, Castellví-Bel, Sergi, Andreu, Montserrat
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 14.04.2016
Public Library of Science (PLoS)
Subjects
Adenoma
Adenoma - genetics
Aged
Alleles
Analysis
Biology and Life Sciences
Cancer
Cancer screening
Case studies
Case-Control Studies
Chromosomes
Colon
Colonoscopy
Colonoscòpia
Colorectal cancer
Colorectal carcinoma
Colorectal Neoplasms - genetics
Càncer colorectal
Disease susceptibility
Epidemiology
Estudi de casos
Female
Gastroenterology
Gene Frequency
Genetic aspects
Genetic diversity
Genetic Predisposition to Disease - genetics
Genetic variance
Genetic variation
Genome-Wide Association Study
Genomes
Genotype
Genètica humana
Health risks
Hospitals
Human genetics
Humans
Lesions
Logistic Models
Male
Medical research
Medicine and Health Sciences
Middle Aged
Mortality
Multivariate Analysis
Mutació (Biologia)
Mutation (Biology)
Patients
Physiological aspects
Polymorphism, Single Nucleotide
Research and Analysis Methods
Risk
Risk Assessment - methods
Risk Assessment - statistics & numerical data
Risk Factors
Screening
Statistical analysis
Studies
Tumors
Spain
Online AccessGet full text

Cover

Abstract Common low-penetrance genetic variants have been consistently associated with colorectal cancer risk. To determine if these genetic variants are associated also with adenoma susceptibility and may improve selection of patients with increased risk for advanced adenomas and/or multiplicity (≥ 3 adenomas). We selected 1,326 patients with increased risk for advanced adenomas and/or multiplicity and 1,252 controls with normal colonoscopy from population-based colorectal cancer screening programs. We conducted a case-control association study analyzing 30 colorectal cancer susceptibility variants in order to investigate the contribution of these variants to the development of subsequent advanced neoplasia and/or multiplicity. We found that 14 of the analyzed genetic variants showed a statistically significant association with advanced adenomas and/or multiplicity: the probability of developing these lesions increased with the number of risk alleles reaching a 2.3-fold risk increment in individuals with ≥ 17 risk alleles. Nearly half of the genetic variants associated with colorectal cancer risk are also related to advanced adenoma and/or multiplicity predisposition. Assessing the number of risk alleles in individuals within colorectal cancer screening programs may help to identify better a subgroup with increased risk for advanced neoplasia and/or multiplicity in the general population.
AbstractList BACKGROUNDCommon low-penetrance genetic variants have been consistently associated with colorectal cancer risk.AIMTo determine if these genetic variants are associated also with adenoma susceptibility and may improve selection of patients with increased risk for advanced adenomas and/or multiplicity (≥ 3 adenomas).METHODSWe selected 1,326 patients with increased risk for advanced adenomas and/or multiplicity and 1,252 controls with normal colonoscopy from population-based colorectal cancer screening programs. We conducted a case-control association study analyzing 30 colorectal cancer susceptibility variants in order to investigate the contribution of these variants to the development of subsequent advanced neoplasia and/or multiplicity.RESULTSWe found that 14 of the analyzed genetic variants showed a statistically significant association with advanced adenomas and/or multiplicity: the probability of developing these lesions increased with the number of risk alleles reaching a 2.3-fold risk increment in individuals with ≥ 17 risk alleles.CONCLUSIONSNearly half of the genetic variants associated with colorectal cancer risk are also related to advanced adenoma and/or multiplicity predisposition. Assessing the number of risk alleles in individuals within colorectal cancer screening programs may help to identify better a subgroup with increased risk for advanced neoplasia and/or multiplicity in the general population.
Background Common low-penetrance genetic variants have been consistently associated with colorectal cancer risk. Aim To determine if these genetic variants are associated also with adenoma susceptibility and may improve selection of patients with increased risk for advanced adenomas and/or multiplicity ([greater than or equal to] 3 adenomas). Methods We selected 1,326 patients with increased risk for advanced adenomas and/or multiplicity and 1,252 controls with normal colonoscopy from population-based colorectal cancer screening programs. We conducted a case-control association study analyzing 30 colorectal cancer susceptibility variants in order to investigate the contribution of these variants to the development of subsequent advanced neoplasia and/or multiplicity. Results We found that 14 of the analyzed genetic variants showed a statistically significant association with advanced adenomas and/or multiplicity: the probability of developing these lesions increased with the number of risk alleles reaching a 2.3-fold risk increment in individuals with [greater than or equal to] 17 risk alleles. Conclusions Nearly half of the genetic variants associated with colorectal cancer risk are also related to advanced adenoma and/or multiplicity predisposition. Assessing the number of risk alleles in individuals within colorectal cancer screening programs may help to identify better a subgroup with increased risk for advanced neoplasia and/or multiplicity in the general population.
Background Common low-penetrance genetic variants have been consistently associated with colorec- tal cancer risk. Aim To determine if these genetic variants are associated also with adenoma susceptibility and may improve selection of patients with increased risk for advanced adenomas and/or multi- plicity ( 3 adenomas). Methods We selected 1,326 patients with increased risk for advanced adenomas and/or multiplicity and 1,252 controls with normal colonoscopy from population-based colorectal cancer screening programs. We conducted a case-control association study analyzing 30 colorec- tal cancer susceptibility variants in order to investigate the contribution of these variants to the development of subsequent advanced neoplasia and/or multiplicity. Results We found that 14 of the analyzed genetic variants showed a statistically significant associa- tion with advanced adenomas and/or multiplicity: the probability of developing these lesions increased with the number of risk alleles reaching a 2.3-fold risk increment in individuals with 17 risk alleles. Conclusions Nearly half of the genetic variants associated with colorectal cancer risk are also related to advanced adenoma and/or multiplicity predisposition. Assessing the number of risk alleles in individuals within colorectal cancer screening programs may help to identify better a sub- group with increased risk for advanced neoplasia and/or multiplicity in the general population.
Common low-penetrance genetic variants have been consistently associated with colorectal cancer risk. To determine if these genetic variants are associated also with adenoma susceptibility and may improve selection of patients with increased risk for advanced adenomas and/or multiplicity ([greater than or equal to] 3 adenomas). We selected 1,326 patients with increased risk for advanced adenomas and/or multiplicity and 1,252 controls with normal colonoscopy from population-based colorectal cancer screening programs. We conducted a case-control association study analyzing 30 colorectal cancer susceptibility variants in order to investigate the contribution of these variants to the development of subsequent advanced neoplasia and/or multiplicity. We found that 14 of the analyzed genetic variants showed a statistically significant association with advanced adenomas and/or multiplicity: the probability of developing these lesions increased with the number of risk alleles reaching a 2.3-fold risk increment in individuals with [greater than or equal to] 17 risk alleles. Nearly half of the genetic variants associated with colorectal cancer risk are also related to advanced adenoma and/or multiplicity predisposition. Assessing the number of risk alleles in individuals within colorectal cancer screening programs may help to identify better a subgroup with increased risk for advanced neoplasia and/or multiplicity in the general population.
Common low-penetrance genetic variants have been consistently associated with colorectal cancer risk. To determine if these genetic variants are associated also with adenoma susceptibility and may improve selection of patients with increased risk for advanced adenomas and/or multiplicity (≥ 3 adenomas). We selected 1,326 patients with increased risk for advanced adenomas and/or multiplicity and 1,252 controls with normal colonoscopy from population-based colorectal cancer screening programs. We conducted a case-control association study analyzing 30 colorectal cancer susceptibility variants in order to investigate the contribution of these variants to the development of subsequent advanced neoplasia and/or multiplicity. We found that 14 of the analyzed genetic variants showed a statistically significant association with advanced adenomas and/or multiplicity: the probability of developing these lesions increased with the number of risk alleles reaching a 2.3-fold risk increment in individuals with ≥ 17 risk alleles. Nearly half of the genetic variants associated with colorectal cancer risk are also related to advanced adenoma and/or multiplicity predisposition. Assessing the number of risk alleles in individuals within colorectal cancer screening programs may help to identify better a subgroup with increased risk for advanced neoplasia and/or multiplicity in the general population.
Background Common low-penetrance genetic variants have been consistently associated with colorectal cancer risk. Aim To determine if these genetic variants are associated also with adenoma susceptibility and may improve selection of patients with increased risk for advanced adenomas and/or multiplicity (≥ 3 adenomas). Methods We selected 1,326 patients with increased risk for advanced adenomas and/or multiplicity and 1,252 controls with normal colonoscopy from population-based colorectal cancer screening programs. We conducted a case-control association study analyzing 30 colorectal cancer susceptibility variants in order to investigate the contribution of these variants to the development of subsequent advanced neoplasia and/or multiplicity. Results We found that 14 of the analyzed genetic variants showed a statistically significant association with advanced adenomas and/or multiplicity: the probability of developing these lesions increased with the number of risk alleles reaching a 2.3-fold risk increment in individuals with ≥ 17 risk alleles. Conclusions Nearly half of the genetic variants associated with colorectal cancer risk are also related to advanced adenoma and/or multiplicity predisposition. Assessing the number of risk alleles in individuals within colorectal cancer screening programs may help to identify better a subgroup with increased risk for advanced neoplasia and/or multiplicity in the general population.
Background Common low-penetrance genetic variants have been consistently associated with colorectal cancer risk. Aim To determine if these genetic variants are associated also with adenoma susceptibility and may improve selection of patients with increased risk for advanced adenomas and/or multiplicity (≥ 3 adenomas). Methods We selected 1,326 patients with increased risk for advanced adenomas and/or multiplicity and 1,252 controls with normal colonoscopy from population-based colorectal cancer screening programs. We conducted a case-control association study analyzing 30 colorectal cancer susceptibility variants in order to investigate the contribution of these variants to the development of subsequent advanced neoplasia and/or multiplicity. Results We found that 14 of the analyzed genetic variants showed a statistically significant association with advanced adenomas and/or multiplicity: the probability of developing these lesions increased with the number of risk alleles reaching a 2.3-fold risk increment in individuals with ≥ 17 risk alleles. Conclusions Nearly half of the genetic variants associated with colorectal cancer risk are also related to advanced adenoma and/or multiplicity predisposition. Assessing the number of risk alleles in individuals within colorectal cancer screening programs may help to identify better a subgroup with increased risk for advanced neoplasia and/or multiplicity in the general population.
Audience Academic
Author Álvarez-Urturi, Cristina
Castells, Antoni
Bessa, Xavier
Lozano, Juan José
Grau, Jaume
Hernández, Cristina
Guayta, Rafael
Pellisé, Maria
Macià, Francesc
Castellví-Bel, Sergi
Burón, Andrea
Esteban-Jurado, Clara
Hijona, Elizabeth
Abulí, Anna
Bujanda, Luis
Andreu, Montserrat
AuthorAffiliation 1 Department of Gastroenterology, Hospital del Mar, IMIM (Hospital del Mar Medical Research Institute), Pompeu Fabra University, Passeig Marítim 25–29, 08003, Barcelona, Catalonia, Spain
Sapporo Medical University, JAPAN
2 Department of Gastroenterology, Hospital Clínic, CIBERehd, IDIBAPS, University of Barcelona, Villarroel 170, 08036, Barcelona, Catalonia, Spain
7 Planning and Research Unit, Consell de Collegis Farmacèutics de Catalunya, Girona 64, 08009, Barcelona, Catalonia, Spain
4 Plataforma de Bioinformática, CIBERehd, Villarroel 170, 08036, Barcelona, Catalonia, Spain
6 Unitat d’Avaluació, Suport i Preventiva, Hospital Clínic, Roselló 138, 08036, Barcelona, Catalonia, Spain
3 Department of Gastroenterology, Hospital Donostia/Instituto Biodonostia, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Universidad del País Vasco (UPV/EHU), Doctor Begiristain Kalea, 20014, Donostia/Gipuzkoa, Spain
5 Department of Epidemiology and Evaluation, Hospital
AuthorAffiliation_xml – name: 2 Department of Gastroenterology, Hospital Clínic, CIBERehd, IDIBAPS, University of Barcelona, Villarroel 170, 08036, Barcelona, Catalonia, Spain
– name: 5 Department of Epidemiology and Evaluation, Hospital del Mar, IMIM (Hospital del Mar Medical Research Institute), Passeig Marítim 25–29, 08003, Barcelona, Catalonia, Spain
– name: 7 Planning and Research Unit, Consell de Collegis Farmacèutics de Catalunya, Girona 64, 08009, Barcelona, Catalonia, Spain
– name: Sapporo Medical University, JAPAN
– name: 6 Unitat d’Avaluació, Suport i Preventiva, Hospital Clínic, Roselló 138, 08036, Barcelona, Catalonia, Spain
– name: 1 Department of Gastroenterology, Hospital del Mar, IMIM (Hospital del Mar Medical Research Institute), Pompeu Fabra University, Passeig Marítim 25–29, 08003, Barcelona, Catalonia, Spain
– name: 3 Department of Gastroenterology, Hospital Donostia/Instituto Biodonostia, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Universidad del País Vasco (UPV/EHU), Doctor Begiristain Kalea, 20014, Donostia/Gipuzkoa, Spain
– name: 4 Plataforma de Bioinformática, CIBERehd, Villarroel 170, 08036, Barcelona, Catalonia, Spain
Author_xml – sequence: 1
  givenname: Anna
  surname: Abulí
  fullname: Abulí, Anna
  organization: Department of Gastroenterology, Hospital del Mar, IMIM (Hospital del Mar Medical Research Institute), Pompeu Fabra University, Passeig Marítim 25-29, 08003, Barcelona, Catalonia, Spain
– sequence: 2
  givenname: Antoni
  surname: Castells
  fullname: Castells, Antoni
  organization: Department of Gastroenterology, Hospital Clínic, CIBERehd, IDIBAPS, University of Barcelona, Villarroel 170, 08036, Barcelona, Catalonia, Spain
– sequence: 3
  givenname: Luis
  surname: Bujanda
  fullname: Bujanda, Luis
  organization: Department of Gastroenterology, Hospital Donostia/Instituto Biodonostia, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Universidad del País Vasco (UPV/EHU), Doctor Begiristain Kalea, 20014, Donostia/Gipuzkoa, Spain
– sequence: 4
  givenname: Juan José
  surname: Lozano
  fullname: Lozano, Juan José
  organization: Plataforma de Bioinformática, CIBERehd, Villarroel 170, 08036, Barcelona, Catalonia, Spain
– sequence: 5
  givenname: Xavier
  surname: Bessa
  fullname: Bessa, Xavier
  organization: Department of Gastroenterology, Hospital del Mar, IMIM (Hospital del Mar Medical Research Institute), Pompeu Fabra University, Passeig Marítim 25-29, 08003, Barcelona, Catalonia, Spain
– sequence: 6
  givenname: Cristina
  surname: Hernández
  fullname: Hernández, Cristina
  organization: Department of Epidemiology and Evaluation, Hospital del Mar, IMIM (Hospital del Mar Medical Research Institute), Passeig Marítim 25-29, 08003, Barcelona, Catalonia, Spain
– sequence: 7
  givenname: Cristina
  surname: Álvarez-Urturi
  fullname: Álvarez-Urturi, Cristina
  organization: Department of Gastroenterology, Hospital del Mar, IMIM (Hospital del Mar Medical Research Institute), Pompeu Fabra University, Passeig Marítim 25-29, 08003, Barcelona, Catalonia, Spain
– sequence: 8
  givenname: Maria
  surname: Pellisé
  fullname: Pellisé, Maria
  organization: Department of Gastroenterology, Hospital Clínic, CIBERehd, IDIBAPS, University of Barcelona, Villarroel 170, 08036, Barcelona, Catalonia, Spain
– sequence: 9
  givenname: Clara
  surname: Esteban-Jurado
  fullname: Esteban-Jurado, Clara
  organization: Department of Gastroenterology, Hospital Clínic, CIBERehd, IDIBAPS, University of Barcelona, Villarroel 170, 08036, Barcelona, Catalonia, Spain
– sequence: 10
  givenname: Elizabeth
  surname: Hijona
  fullname: Hijona, Elizabeth
  organization: Department of Gastroenterology, Hospital Donostia/Instituto Biodonostia, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Universidad del País Vasco (UPV/EHU), Doctor Begiristain Kalea, 20014, Donostia/Gipuzkoa, Spain
– sequence: 11
  givenname: Andrea
  surname: Burón
  fullname: Burón, Andrea
  organization: Department of Epidemiology and Evaluation, Hospital del Mar, IMIM (Hospital del Mar Medical Research Institute), Passeig Marítim 25-29, 08003, Barcelona, Catalonia, Spain
– sequence: 12
  givenname: Francesc
  surname: Macià
  fullname: Macià, Francesc
  organization: Department of Epidemiology and Evaluation, Hospital del Mar, IMIM (Hospital del Mar Medical Research Institute), Passeig Marítim 25-29, 08003, Barcelona, Catalonia, Spain
– sequence: 13
  givenname: Jaume
  surname: Grau
  fullname: Grau, Jaume
  organization: Unitat d'Avaluació, Suport i Preventiva, Hospital Clínic, Roselló 138, 08036, Barcelona, Catalonia, Spain
– sequence: 14
  givenname: Rafael
  surname: Guayta
  fullname: Guayta, Rafael
  organization: Planning and Research Unit, Consell de Collegis Farmacèutics de Catalunya, Girona 64, 08009, Barcelona, Catalonia, Spain
– sequence: 15
  givenname: Sergi
  surname: Castellví-Bel
  fullname: Castellví-Bel, Sergi
  organization: Department of Gastroenterology, Hospital Clínic, CIBERehd, IDIBAPS, University of Barcelona, Villarroel 170, 08036, Barcelona, Catalonia, Spain
– sequence: 16
  givenname: Montserrat
  surname: Andreu
  fullname: Andreu, Montserrat
  organization: Department of Gastroenterology, Hospital del Mar, IMIM (Hospital del Mar Medical Research Institute), Pompeu Fabra University, Passeig Marítim 25-29, 08003, Barcelona, Catalonia, Spain
BackLink https://www.ncbi.nlm.nih.gov/pubmed/27078840$$D View this record in MEDLINE/PubMed
BookMark eNqNk11v0zAUhiM0xLbCP0BQCQnBRYs_Y-cGqVQwKk2axGC3luPYrSs37mwH2L_HXbOqQZNAUZTk5HmPfd7jc16ctL7VRfESginEDH5Y-y600k23OTwFkGLAyZPiDFYYTUoE8MnR-2lxHuMaAIp5WT4rThEDjHMCzopPF7rVyarxjQxWtimOZzF6ZWXSzfiXTavx3DsftErSjWeNbv1Gjq-7qPQ22do6m-6eF0-NdFG_6J-j4seXz9_nXyeXVxeL-exyoljJ0gQjzjiulKyhAdBUTErOG4ghqyUwlabaEKIagLFpAIINRcTAGmFUU6OBwXhUvN7n3TofRV9-FJBxCClhGGVisScaL9diG-xGhjvhpRX3AR-WQoZcrNMCQ8MIqijEHJBScS6zhYgbAKTUnFc518d-ta7e6EbpNgXpBkmHf1q7Ekv_UxCeS8I0J4D7BCp2SmQHdVAy3QsPH7sbAYYEKjnOwlHxrl80-NtOxyQ2NlvtnGy173KtHFBSlTRv-59otoVihvhuJ2_-Qh83r6eWMvtjW-NzWWqXVMwIxYRwiFimpo9Q-Wr0xqp8FI3N8YHg_UCQmaR_p6XsYhSL62__z17dDNm3R-xKS5dW0bsuWd_GIUj6PgQfY9Dm0EMIxG6SHtwQu0kS_SRl2avj_h9ED6OD_wDa-xeu
CitedBy_id crossref_primary_10_1016_j_bpg_2023_101848
crossref_primary_10_1007_s10620_021_07218_5
crossref_primary_10_1053_j_gastro_2018_03_030
crossref_primary_10_1155_2018_9853192
crossref_primary_10_1186_s40246_019_0196_4
crossref_primary_10_1053_j_gastro_2018_12_012
crossref_primary_10_18632_oncotarget_24136
crossref_primary_10_1016_j_bpg_2016_10_005
crossref_primary_10_1371_journal_pone_0225779
crossref_primary_10_1136_gutjnl_2019_319313
crossref_primary_10_1136_jmedgenet_2019_106374
crossref_primary_10_1158_1055_9965_EPI_20_0465
Cites_doi 10.1053/j.gastro.2012.09.016
10.1086/519795
10.1053/j.gastro.2006.03.012
10.1093/carcin/bgs308
10.1053/j.gastro.2008.03.040
10.1038/nrg2574
10.1016/S1052-5157(18)30294-0
10.1186/1471-2164-14-55
10.1016/S0140-6736(89)92750-5
10.1038/ng.133
10.1136/gut.2011.239772
10.1038/ng.262
10.1056/NEJMoa1100370
10.1038/ng.111
10.1093/hmg/ddn166
10.1053/j.gastro.2008.02.002
10.1038/nrc2840
10.1086/429864
10.1038/ng.2505
10.1038/ng.2007.41
10.1038/ajg.2012.161
10.1111/j.2517-6161.1995.tb02031.x
10.1053/j.gastro.2010.05.072
10.7326/0003-4819-149-9-200811040-00245
10.1038/ng.670
10.1016/j.ejca.2012.12.027
10.1038/bjc.2012.329
10.1038/ejhg.2014.74
10.1038/ng.406
10.1038/ng1706
10.1038/ng.2293
10.1371/journal.pgen.1002105
10.1053/j.gastro.2012.12.020
10.1007/s10654-011-9567-4
10.1038/ng.2007.18
10.1093/aje/kwu114
10.1136/gut.2006.101428
10.1038/ng2085
ContentType Journal Article
Contributor Castells, Antoni
Courtier, Ricard
Piracés, Mercè
Costa, Rosa
Álvarez, Cristina
Bory, Felipe
Rodríguez, Cristina
Pellisé, Maria
Sivilla, Judith
Balaguer, Francesc
Sala, Maria
Andreu, Montserrat
Polbach, Sandra
Reig, Anna
Serradesanferm, Anna
Bessa, Xavier
Estrada, Maria
Comas, Mercè
Grau, Jaume
Castells, Xavier
Hernández, Cristina
Moreira, Leticia
Navarro, Gemma
Trilla, Antoni
López-Cerón, María
Augé, Josep M
Guayta, Rafael
Seoane, Agustín
Pozo, Àngels
Macià, Francesc
Dedeu, Josep M
Iglesias, Mar
Ocaña, Teresa
Murciano, M Francisca
Burón, Andrea
Pintanell, Mercè
Garrell, Imma
Cuatrecasas, Míriam
Barau, Mercè
Universitat de Barcelona
Contributor_xml – sequence: 1
  givenname: Cristina
  surname: Álvarez
  fullname: Álvarez, Cristina
– sequence: 1
  fullname: Universitat de Barcelona
– sequence: 2
  givenname: Montserrat
  surname: Andreu
  fullname: Andreu, Montserrat
– sequence: 3
  givenname: Josep M
  surname: Augé
  fullname: Augé, Josep M
– sequence: 4
  givenname: Francesc
  surname: Balaguer
  fullname: Balaguer, Francesc
– sequence: 5
  givenname: Mercè
  surname: Barau
  fullname: Barau, Mercè
– sequence: 6
  givenname: Xavier
  surname: Bessa
  fullname: Bessa, Xavier
– sequence: 7
  givenname: Felipe
  surname: Bory
  fullname: Bory, Felipe
– sequence: 8
  givenname: Andrea
  surname: Burón
  fullname: Burón, Andrea
– sequence: 9
  givenname: Antoni
  surname: Castells
  fullname: Castells, Antoni
– sequence: 10
  givenname: Xavier
  surname: Castells
  fullname: Castells, Xavier
– sequence: 11
  givenname: Mercè
  surname: Comas
  fullname: Comas, Mercè
– sequence: 12
  givenname: Rosa
  surname: Costa
  fullname: Costa, Rosa
– sequence: 13
  givenname: Ricard
  surname: Courtier
  fullname: Courtier, Ricard
– sequence: 14
  givenname: Míriam
  surname: Cuatrecasas
  fullname: Cuatrecasas, Míriam
– sequence: 15
  givenname: Josep M
  surname: Dedeu
  fullname: Dedeu, Josep M
– sequence: 16
  givenname: Maria
  surname: Estrada
  fullname: Estrada, Maria
– sequence: 17
  givenname: Imma
  surname: Garrell
  fullname: Garrell, Imma
– sequence: 18
  givenname: Jaume
  surname: Grau
  fullname: Grau, Jaume
– sequence: 19
  givenname: Rafael
  surname: Guayta
  fullname: Guayta, Rafael
– sequence: 20
  givenname: Cristina
  surname: Hernández
  fullname: Hernández, Cristina
– sequence: 21
  givenname: Mar
  surname: Iglesias
  fullname: Iglesias, Mar
– sequence: 22
  givenname: María
  surname: López-Cerón
  fullname: López-Cerón, María
– sequence: 23
  givenname: Francesc
  surname: Macià
  fullname: Macià, Francesc
– sequence: 24
  givenname: Leticia
  surname: Moreira
  fullname: Moreira, Leticia
– sequence: 25
  givenname: M Francisca
  surname: Murciano
  fullname: Murciano, M Francisca
– sequence: 26
  givenname: Gemma
  surname: Navarro
  fullname: Navarro, Gemma
– sequence: 27
  givenname: Teresa
  surname: Ocaña
  fullname: Ocaña, Teresa
– sequence: 28
  givenname: Maria
  surname: Pellisé
  fullname: Pellisé, Maria
– sequence: 29
  givenname: Mercè
  surname: Pintanell
  fullname: Pintanell, Mercè
– sequence: 30
  givenname: Mercè
  surname: Piracés
  fullname: Piracés, Mercè
– sequence: 31
  givenname: Sandra
  surname: Polbach
  fullname: Polbach, Sandra
– sequence: 32
  givenname: Àngels
  surname: Pozo
  fullname: Pozo, Àngels
– sequence: 33
  givenname: Anna
  surname: Reig
  fullname: Reig, Anna
– sequence: 34
  givenname: Cristina
  surname: Rodríguez
  fullname: Rodríguez, Cristina
– sequence: 35
  givenname: Maria
  surname: Sala
  fullname: Sala, Maria
– sequence: 36
  givenname: Agustín
  surname: Seoane
  fullname: Seoane, Agustín
– sequence: 37
  givenname: Anna
  surname: Serradesanferm
  fullname: Serradesanferm, Anna
– sequence: 38
  givenname: Judith
  surname: Sivilla
  fullname: Sivilla, Judith
– sequence: 39
  givenname: Antoni
  surname: Trilla
  fullname: Trilla, Antoni
Copyright COPYRIGHT 2016 Public Library of Science
2016 Abulí et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
cc-by (c) Abulí, Anna et al., 2016 info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/3.0/es
2016 Abulí et al 2016 Abulí et al
Copyright_xml – notice: COPYRIGHT 2016 Public Library of Science
– notice: 2016 Abulí et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: cc-by (c) Abulí, Anna et al., 2016 info:eu-repo/semantics/openAccess <a href="http://creativecommons.org/licenses/by/3.0/es">http://creativecommons.org/licenses/by/3.0/es</a>
– notice: 2016 Abulí et al 2016 Abulí et al
CorporateAuthor PROCOLON research group
CorporateAuthor_xml – name: PROCOLON research group
DBID CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
IOV
ISR
3V.
7QG
7QL
7QO
7RV
7SN
7SS
7T5
7TG
7TM
7U9
7X2
7X7
7XB
88E
8AO
8C1
8FD
8FE
8FG
8FH
8FI
8FJ
8FK
ABJCF
ABUWG
AFKRA
ARAPS
ATCPS
AZQEC
BBNVY
BENPR
BGLVJ
BHPHI
C1K
CCPQU
D1I
DWQXO
FR3
FYUFA
GHDGH
GNUQQ
H94
HCIFZ
K9.
KB.
KB0
KL.
L6V
LK8
M0K
M0S
M1P
M7N
M7P
M7S
NAPCQ
P5Z
P62
P64
PATMY
PDBOC
PIMPY
PQEST
PQQKQ
PQUKI
PRINS
PTHSS
PYCSY
RC3
7X8
XX2
5PM
DOA
DOI 10.1371/journal.pone.0153084
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
Opposing Viewpoints Resource Center
Gale In Context: Science
ProQuest Central (Corporate)
Animal Behavior Abstracts
Bacteriology Abstracts (Microbiology B)
Biotechnology Research Abstracts
ProQuest Nursing and Allied Health Journals
Ecology Abstracts
Entomology Abstracts (Full archive)
Immunology Abstracts
Meteorological & Geoastrophysical Abstracts
Nucleic Acids Abstracts
Virology and AIDS Abstracts
Agricultural Science Collection
Health & Medical Complete (ProQuest Database)
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
ProQuest Pharma Collection
ProQuest Public Health Database
Technology Research Database
ProQuest SciTech Collection
ProQuest Technology Collection
ProQuest Natural Science Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
Materials Science & Engineering Collection
ProQuest Central (Alumni Edition)
ProQuest Central UK/Ireland
Advanced Technologies & Aerospace Collection
Agricultural & Environmental Science Collection
ProQuest Central Essentials
Biological Science Collection
ProQuest Central
Technology Collection
ProQuest Natural Science Collection
Environmental Sciences and Pollution Management
ProQuest One Community College
ProQuest Materials Science Collection
ProQuest Central Korea
Engineering Research Database
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
AIDS and Cancer Research Abstracts
SciTech Premium Collection (Proquest) (PQ_SDU_P3)
ProQuest Health & Medical Complete (Alumni)
Materials Science Database
Nursing & Allied Health Database (Alumni Edition)
Meteorological & Geoastrophysical Abstracts - Academic
ProQuest Engineering Collection
ProQuest Biological Science Collection
Agricultural Science Database
Health & Medical Collection (Alumni Edition)
Medical Database
Algology Mycology and Protozoology Abstracts (Microbiology C)
Biological Science Database
Engineering Database
Nursing & Allied Health Premium
Advanced Technologies & Aerospace Database
ProQuest Advanced Technologies & Aerospace Collection
Biotechnology and BioEngineering Abstracts
Environmental Science Database
Materials Science Collection
Access via ProQuest (Open Access)
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
Engineering Collection
Environmental Science Collection
Genetics Abstracts
MEDLINE - Academic
Recercat
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
Agricultural Science Database
Publicly Available Content Database
ProQuest Central Student
ProQuest Advanced Technologies & Aerospace Collection
ProQuest Central Essentials
Nucleic Acids Abstracts
SciTech Premium Collection
ProQuest Central China
Environmental Sciences and Pollution Management
Health Research Premium Collection
Meteorological & Geoastrophysical Abstracts
Natural Science Collection
Biological Science Collection
ProQuest Medical Library (Alumni)
Engineering Collection
Advanced Technologies & Aerospace Collection
Engineering Database
Virology and AIDS Abstracts
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
Agricultural Science Collection
ProQuest Hospital Collection
ProQuest Technology Collection
Health Research Premium Collection (Alumni)
Biological Science Database
Ecology Abstracts
ProQuest Hospital Collection (Alumni)
Biotechnology and BioEngineering Abstracts
Environmental Science Collection
Entomology Abstracts
Nursing & Allied Health Premium
ProQuest Health & Medical Complete
ProQuest One Academic UKI Edition
Environmental Science Database
ProQuest Nursing & Allied Health Source (Alumni)
Engineering Research Database
ProQuest One Academic
Meteorological & Geoastrophysical Abstracts - Academic
Technology Collection
Technology Research Database
Materials Science Collection
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest Natural Science Collection
ProQuest Pharma Collection
ProQuest Central
Genetics Abstracts
ProQuest Engineering Collection
Biotechnology Research Abstracts
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
Bacteriology Abstracts (Microbiology B)
Algology Mycology and Protozoology Abstracts (Microbiology C)
Agricultural & Environmental Science Collection
AIDS and Cancer Research Abstracts
Materials Science Database
ProQuest Materials Science Collection
ProQuest Public Health
ProQuest Nursing & Allied Health Source
ProQuest SciTech Collection
Advanced Technologies & Aerospace Database
ProQuest Medical Library
Animal Behavior Abstracts
Materials Science & Engineering Collection
Immunology Abstracts
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList MEDLINE - Academic



MEDLINE




Agricultural Science Database
Genetics Abstracts
Database_xml – sequence: 1
  dbid: DOA
  name: Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 4
  dbid: 8FG
  name: ProQuest Technology Collection
  url: https://search.proquest.com/technologycollection1
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Sciences (General)
DocumentTitleAlternate Genetic Susceptibility and Colorectal Adenoma
EISSN 1932-6203
Editor Suzuki, Hiromu
Editor_xml – sequence: 1
  givenname: Hiromu
  surname: Suzuki
  fullname: Suzuki, Hiromu
EndPage e0153084
ExternalDocumentID 1781154732
oai_doaj_org_article_31f74295138046c88a01528f00aae889
oai_recercat_cat_2072_268348
4023298621
A453448127
10_1371_journal_pone_0153084
27078840
Genre Research Support, Non-U.S. Gov't
Journal Article
GeographicLocations Spain
GeographicLocations_xml – name: Spain
GrantInformation_xml – fundername: ;
– fundername: ;
  grantid: SAF2010-19273
– fundername: ;
  grantid: PI14/00173
– fundername: ;
  grantid: 2014SGR255, 2014SGR135
– fundername: ;
  grantid: PI11/00219
– fundername: ;
  grantid: RD09/0076/00036
– fundername: ;
  grantid: PI14/00441
– fundername: ;
  grantid: CP 03-0070
– fundername: ;
  grantid: PI10/00918
– fundername: ;
  grantid: GCB13131592CAST
GroupedDBID ---
123
29O
2WC
3V.
53G
5VS
7RV
7X2
7X7
7XC
88E
8AO
8C1
8CJ
8FE
8FG
8FH
8FI
8FJ
A8Z
AAFWJ
ABDBF
ABIVO
ABJCF
ABUWG
ACGFO
ACIHN
ACIWK
ACPRK
ADBBV
ADRAZ
AEAQA
AENEX
AFKRA
AFRAH
AHMBA
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AOIJS
APEBS
ARAPS
ATCPS
BAWUL
BBNVY
BBORY
BCNDV
BENPR
BGLVJ
BHPHI
BKEYQ
BPHCQ
BVXVI
BWKFM
CCPQU
CGR
CS3
CUY
CVF
D1I
D1J
D1K
DIK
DU5
E3Z
EAP
EAS
EBD
ECM
EIF
EMOBN
ESTFP
ESX
EX3
F5P
FPL
FYUFA
GROUPED_DOAJ
GX1
HCIFZ
HH5
HMCUK
HYE
IAO
IEA
IHR
IHW
INH
INR
IOV
IPNFZ
IPY
ISE
ISR
ITC
K6-
KB.
KQ8
L6V
LK5
LK8
M0K
M1P
M48
M7P
M7R
M7S
M~E
NAPCQ
NPM
O5R
O5S
OK1
P2P
P62
PATMY
PDBOC
PIMPY
PQQKQ
PROAC
PSQYO
PTHSS
PV9
PYCSY
RIG
RNS
RPM
RZL
SV3
TR2
UKHRP
WOQ
WOW
~02
~KM
AAYXX
AFPKN
CITATION
7QG
7QL
7QO
7SN
7SS
7T5
7TG
7TM
7U9
7XB
8FD
8FK
AZQEC
C1K
DWQXO
FR3
GNUQQ
H94
K9.
KL.
M7N
P64
PQEST
PQUKI
PRINS
RC3
7X8
XX2
5PM
AAPBV
ABPTK
N95
ID FETCH-LOGICAL-c767t-3287839cab1f01f97aa88d1317ba0f9e5ef44cd033fd021d524f1b232b5fe0f33
IEDL.DBID RPM
ISSN 1932-6203
IngestDate Sun Jul 02 11:03:55 EDT 2023
Tue Oct 22 15:13:42 EDT 2024
Tue Sep 17 21:13:17 EDT 2024
Fri Nov 01 12:58:22 EDT 2024
Fri Oct 25 04:49:18 EDT 2024
Fri Oct 25 01:02:13 EDT 2024
Thu Oct 10 16:10:45 EDT 2024
Thu Feb 22 23:41:45 EST 2024
Fri Feb 02 04:26:34 EST 2024
Thu Aug 01 19:36:19 EDT 2024
Thu Aug 01 20:12:46 EDT 2024
Tue Aug 20 22:09:55 EDT 2024
Fri Aug 23 04:03:33 EDT 2024
Wed Oct 16 00:48:56 EDT 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 4
Language English
License This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Creative Commons Attribution License
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c767t-3287839cab1f01f97aa88d1317ba0f9e5ef44cd033fd021d524f1b232b5fe0f33
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Competing Interests: The authors have declared that no competing interests exist.
All members of the PROCOLON group are listed in the Appendix.
Conceived and designed the experiments: AA AC JJL SCB MA. Performed the experiments: AA CH CEJ EH LB XB SCB. Analyzed the data: AA AC JJL CH SCB MA. Contributed reagents/materials/analysis tools: AA AC MA SCB LB XB CAU MP AB FM JG RG. Wrote the paper: AA MA JJL AC SCB. Selection of samples stored in the Biobank of Hospital del Mar and Hospital Donosti: AA EH.
OpenAccessLink https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4831735/
PMID 27078840
PQID 1781154732
PQPubID 1436336
PageCount 12
ParticipantIDs plos_journals_1781154732
doaj_primary_oai_doaj_org_article_31f74295138046c88a01528f00aae889
pubmedcentral_primary_oai_pubmedcentral_nih_gov_4831735
csuc_recercat_oai_recercat_cat_2072_268348
proquest_miscellaneous_1805496551
proquest_miscellaneous_1781537285
proquest_journals_1781154732
gale_infotracmisc_A453448127
gale_infotracacademiconefile_A453448127
gale_incontextgauss_ISR_A453448127
gale_incontextgauss_IOV_A453448127
gale_healthsolutions_A453448127
crossref_primary_10_1371_journal_pone_0153084
pubmed_primary_27078840
PublicationCentury 2000
PublicationDate 2016-04-14
PublicationDateYYYYMMDD 2016-04-14
PublicationDate_xml – month: 04
  year: 2016
  text: 2016-04-14
  day: 14
PublicationDecade 2010
PublicationPlace United States
PublicationPlace_xml – name: United States
– name: San Francisco
– name: San Francisco, CA USA
PublicationTitle PloS one
PublicationTitleAlternate PLoS One
PublicationYear 2016
Publisher Public Library of Science
Public Library of Science (PLoS)
Publisher_xml – name: Public Library of Science
– name: Public Library of Science (PLoS)
References I Tomlinson (ref21) 2007; 39
U Peters (ref18) 2013; 144
AI Neugut (ref2) 1997; 7
B Levin (ref4) 2008; 134
AG Zauber (ref5) 2012; 366
B Kinnersley (ref15) 2012; 107
JE Wigginton (ref30) 2005; 76
DK Rex (ref28) 2012; 107
LG van Rossum (ref7) 2008; 135
RS Houlston (ref12) 2010; 42
RS Houlston (ref11) 2008; 40
AN Burnett-Hartman (ref26) 2014; 180
A Abulí (ref36) 2010; 139
E Jaeger (ref22) 2008; 40
AM Jones (ref20) 2012; 61
A Tenesa (ref10) 2008; 40
LG Carvajal-Carmona (ref25) 2013; 144
S Purcell (ref29) 2007; 81
AD Skol (ref32) 2006; 38
MG Dunlop (ref14) 2012; 44
SI Berndt (ref35) 2008; 17
Y Benjamini (ref31) 1995; 57
C Fernandez-Rozadilla (ref16) 2013; 14
SJ Winawer (ref3) 2006; 130
IP Tomlinson (ref19) 2008; 40
WH Jia (ref17) 2013; 45
TH Cheng (ref27) 2015; 23
JD Hardcastle (ref9) 1989; 1
A Tenesa (ref38) 2009; 10
O Fletcher (ref33) 2010; 10
IP Tomlinson (ref13) 2011; 7
EP Whitlock (ref6) 2008; 149
J Ferlay (ref1) 2013; 49
S Kundu (ref34) 2011; 26
P Broderick (ref23) 2007; 39
B Zhang (ref24) 2012; 33
L Guittet (ref8) 2007; 56
S Tuupanen (ref37) 2009; 4
References_xml – volume: 144
  start-page: 53
  year: 2013
  ident: ref25
  article-title: Much of the genetic risk of colorectal cancer is likely to be mediated through susceptibility to adenomas
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2012.09.016
  contributor:
    fullname: LG Carvajal-Carmona
– volume: 81
  start-page: 559
  year: 2007
  ident: ref29
  article-title: PLINK: a tool set for whole-genome association and population-based linkage analyses
  publication-title: Am J Hum Genet
  doi: 10.1086/519795
  contributor:
    fullname: S Purcell
– volume: 130
  start-page: 1872
  year: 2006
  ident: ref3
  article-title: Guidelines for colonoscopy surveillance after polypectomy: a consensus update by the US Multi-Society Task Force on Colorectal Cancer and the American Cancer Society
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2006.03.012
  contributor:
    fullname: SJ Winawer
– volume: 33
  start-page: 2417
  year: 2012
  ident: ref24
  article-title: Association of genetic variants for colorectal cancer differs by subtypes of polyps in the colorectum
  publication-title: Carcinogenesis
  doi: 10.1093/carcin/bgs308
  contributor:
    fullname: B Zhang
– volume: 135
  start-page: 82
  year: 2008
  ident: ref7
  article-title: Random comparison of guaiac and immunochemical fecal occult blood tests for colorectal cancer in a screening population
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2008.03.040
  contributor:
    fullname: LG van Rossum
– volume: 10
  start-page: 353
  year: 2009
  ident: ref38
  article-title: New insights into the aetiology of colorectal cancer from genome-wide association studies
  publication-title: Nat Rev Genet
  doi: 10.1038/nrg2574
  contributor:
    fullname: A Tenesa
– volume: 7
  start-page: 387
  year: 1997
  ident: ref2
  article-title: Prevalence and incidence of colorectal adenomas and cancer in asymptomatic persons
  publication-title: Gastrointest Endosc Clin N Am
  doi: 10.1016/S1052-5157(18)30294-0
  contributor:
    fullname: AI Neugut
– volume: 14
  start-page: 55
  year: 2013
  ident: ref16
  article-title: Colorectal cancer genome-wide association study in a Spanish cohort identifies two variants associated with colorectal cancer risk at 1p33 and 8p12
  publication-title: BMC Genomics
  doi: 10.1186/1471-2164-14-55
  contributor:
    fullname: C Fernandez-Rozadilla
– volume: 1
  start-page: 1160
  year: 1989
  ident: ref9
  article-title: Randomised, controlled trial of faecal occult blood screening for colorectal cancer. Results for first 107,349 subjects
  publication-title: Lancet
  doi: 10.1016/S0140-6736(89)92750-5
  contributor:
    fullname: JD Hardcastle
– volume: 40
  start-page: 631
  issue: 5
  year: 2008
  ident: ref10
  article-title: Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21
  publication-title: Nat Genet
  doi: 10.1038/ng.133
  contributor:
    fullname: A Tenesa
– volume: 61
  start-page: 248
  issue: 2
  year: 2012
  ident: ref20
  article-title: TERC polymorphisms are associated both with susceptibility to colorectal cancer and with longer telomeres
  publication-title: Gut
  doi: 10.1136/gut.2011.239772
  contributor:
    fullname: AM Jones
– volume: 40
  start-page: 1426
  year: 2008
  ident: ref11
  article-title: Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer
  publication-title: Nat Genet
  doi: 10.1038/ng.262
  contributor:
    fullname: RS Houlston
– volume: 366
  start-page: 687
  year: 2012
  ident: ref5
  article-title: Colonoscopic polypectomy and long-term prevention of colorectal-cancer deaths
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa1100370
  contributor:
    fullname: AG Zauber
– volume: 40
  start-page: 623
  issue: 5
  year: 2008
  ident: ref19
  article-title: A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3
  publication-title: Nat Genet
  doi: 10.1038/ng.111
  contributor:
    fullname: IP Tomlinson
– volume: 17
  start-page: 2665
  year: 2008
  ident: ref35
  article-title: Pooled analysis of genetic variation at chromosome 8q24 and colorectal neoplasia risk
  publication-title: Hum Mol Genet
  doi: 10.1093/hmg/ddn166
  contributor:
    fullname: SI Berndt
– volume: 134
  start-page: 1570
  year: 2008
  ident: ref4
  article-title: Screening and surveillance for the early detection of colorectal cancer and adenomatous polyps. 2008: a joint guideline from the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the American College of Radiology
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2008.02.002
  contributor:
    fullname: B Levin
– volume: 10
  start-page: 353
  issue: 5
  year: 2010
  ident: ref33
  article-title: Architecture of inherited susceptibility to common cancer
  publication-title: Nat Rev Cancer
  doi: 10.1038/nrc2840
  contributor:
    fullname: O Fletcher
– volume: 76
  start-page: 887
  year: 2005
  ident: ref30
  article-title: A note on exact tests of Hardy-Weinberg equilibrium
  publication-title: Am J Hum Genet
  doi: 10.1086/429864
  contributor:
    fullname: JE Wigginton
– volume: 45
  start-page: 191
  year: 2013
  ident: ref17
  article-title: Genome-wide association analyses in East Asians identify new susceptibility loci for colorectal cancer
  publication-title: Nat Genet
  doi: 10.1038/ng.2505
  contributor:
    fullname: WH Jia
– volume: 40
  start-page: 26
  issue: 1
  year: 2008
  ident: ref22
  article-title: Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk
  publication-title: Nat Genet
  doi: 10.1038/ng.2007.41
  contributor:
    fullname: E Jaeger
– volume: 107
  start-page: 1315
  year: 2012
  ident: ref28
  article-title: Serrated lesions of the colorectum: review and recommendations from an expert panel
  publication-title: Am J Gastroenterol
  doi: 10.1038/ajg.2012.161
  contributor:
    fullname: DK Rex
– volume: 57
  start-page: 289
  issue: 1
  year: 1995
  ident: ref31
  article-title: Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
  publication-title: Journal of the Royal Statistical Society, Series B (Methodological)
  doi: 10.1111/j.2517-6161.1995.tb02031.x
  contributor:
    fullname: Y Benjamini
– volume: 139
  start-page: 788
  year: 2010
  ident: ref36
  article-title: Susceptibility genetic variants associated with colorectal cancer risk correlate with cancer phenotype
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2010.05.072
  contributor:
    fullname: A Abulí
– volume: 149
  start-page: 638
  year: 2008
  ident: ref6
  article-title: Screening for colorectal cancer: a targeted, updated systematic review for the U.S. Preventive Services Task Force
  publication-title: Ann Intern Med
  doi: 10.7326/0003-4819-149-9-200811040-00245
  contributor:
    fullname: EP Whitlock
– volume: 42
  start-page: 973
  year: 2010
  ident: ref12
  article-title: Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33
  publication-title: Nat Genet
  doi: 10.1038/ng.670
  contributor:
    fullname: RS Houlston
– volume: 49
  start-page: 1374
  year: 2013
  ident: ref1
  article-title: Cancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012
  publication-title: Eur J Cancer
  doi: 10.1016/j.ejca.2012.12.027
  contributor:
    fullname: J Ferlay
– volume: 107
  start-page: 1001
  year: 2012
  ident: ref15
  article-title: Colon Cancer Family Registry The TERT variant rs2736100 is associated with colorectal cancer risk
  publication-title: Br J Cancer
  doi: 10.1038/bjc.2012.329
  contributor:
    fullname: B Kinnersley
– volume: 23
  start-page: 260
  year: 2015
  ident: ref27
  article-title: Common colorectal cancer risk alleles contribute to the multiple colorectal adenoma phenotype, but do not influence colonic polyposis in FAP
  publication-title: Eur J Hum Genet
  doi: 10.1038/ejhg.2014.74
  contributor:
    fullname: TH Cheng
– volume: 4
  start-page: 885
  year: 2009
  ident: ref37
  article-title: The common colorectal cancer predisposition SNP rs6983267 at chromosome 8q24 confers potential to enhanced Wnt signaling
  publication-title: Nat Genet
  doi: 10.1038/ng.406
  contributor:
    fullname: S Tuupanen
– volume: 38
  start-page: 209
  year: 2006
  ident: ref32
  article-title: Joint analysis is more efficient than replication-based analysis for two-stage genome-wide association studies
  publication-title: Nat Genet
  doi: 10.1038/ng1706
  contributor:
    fullname: AD Skol
– volume: 44
  start-page: 770
  year: 2012
  ident: ref14
  article-title: Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk
  publication-title: Nat Genet
  doi: 10.1038/ng.2293
  contributor:
    fullname: MG Dunlop
– volume: 7
  start-page: e1002105
  year: 2011
  ident: ref13
  article-title: Multiple common susceptibility variants near BMP pathway loci GREM1, BMP4, and BMP2 explain part of the missing heritability of colorectal cancer
  publication-title: PLoS Genet
  doi: 10.1371/journal.pgen.1002105
  contributor:
    fullname: IP Tomlinson
– volume: 144
  start-page: 799
  year: 2013
  ident: ref18
  article-title: Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2012.12.020
  contributor:
    fullname: U Peters
– volume: 26
  start-page: 261
  issue: 4
  year: 2011
  ident: ref34
  article-title: PredictABEL: an R package for the assessment of risk prediction models
  publication-title: Eur J Epidemiol
  doi: 10.1007/s10654-011-9567-4
  contributor:
    fullname: S Kundu
– volume: 39
  start-page: 1315
  issue: 11
  year: 2007
  ident: ref23
  article-title: A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk
  publication-title: Nat Genet
  doi: 10.1038/ng.2007.18
  contributor:
    fullname: P Broderick
– volume: 180
  start-page: 223
  year: 2014
  ident: ref26
  article-title: Variation in the association between colorectal cancer susceptibility loci and colorectal polyps by polyp type
  publication-title: Am J Epidemiol
  doi: 10.1093/aje/kwu114
  contributor:
    fullname: AN Burnett-Hartman
– volume: 56
  start-page: 210
  year: 2007
  ident: ref8
  article-title: Comparison of a guaiac based and an immunochemical faecal occult blood test in screening for colorectal cancer in a general average risk population
  publication-title: Gut
  doi: 10.1136/gut.2006.101428
  contributor:
    fullname: L Guittet
– volume: 39
  start-page: 984
  year: 2007
  ident: ref21
  article-title: A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21
  publication-title: Nat Genet
  doi: 10.1038/ng2085
  contributor:
    fullname: I Tomlinson
SSID ssj0053866
Score 2.3125246
Snippet Common low-penetrance genetic variants have been consistently associated with colorectal cancer risk. To determine if these genetic variants are associated...
Background Common low-penetrance genetic variants have been consistently associated with colorectal cancer risk. Aim To determine if these genetic variants are...
Common low-penetrance genetic variants have been consistently associated with colorectal cancer risk. To determine if these genetic variants are associated...
BACKGROUNDCommon low-penetrance genetic variants have been consistently associated with colorectal cancer risk.AIMTo determine if these genetic variants are...
Background Common low-penetrance genetic variants have been consistently associated with colorec- tal cancer risk. Aim To determine if these genetic variants...
BACKGROUND:Common low-penetrance genetic variants have been consistently associated with colorectal cancer risk. AIM:To determine if these genetic variants are...
Background Common low-penetrance genetic variants have been consistently associated with colorectal cancer risk. Aim To determine if these genetic variants are...
SourceID plos
doaj
pubmedcentral
csuc
proquest
gale
crossref
pubmed
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
StartPage e0153084
SubjectTerms Adenoma
Adenoma - genetics
Aged
Alleles
Analysis
Biology and Life Sciences
Cancer
Cancer screening
Case studies
Case-Control Studies
Chromosomes
Colon
Colonoscopy
Colonoscòpia
Colorectal cancer
Colorectal carcinoma
Colorectal Neoplasms - genetics
Càncer colorectal
Disease susceptibility
Epidemiology
Estudi de casos
Female
Gastroenterology
Gene Frequency
Genetic aspects
Genetic diversity
Genetic Predisposition to Disease - genetics
Genetic variance
Genetic variation
Genome-Wide Association Study
Genomes
Genotype
Genètica humana
Health risks
Hospitals
Human genetics
Humans
Lesions
Logistic Models
Male
Medical research
Medicine and Health Sciences
Middle Aged
Mortality
Multivariate Analysis
Mutació (Biologia)
Mutation (Biology)
Patients
Physiological aspects
Polymorphism, Single Nucleotide
Research and Analysis Methods
Risk
Risk Assessment - methods
Risk Assessment - statistics & numerical data
Risk Factors
Screening
Statistical analysis
Studies
Tumors
SummonAdditionalLinks – databaseName: DOAJ Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELbQnrggWh4NFAgIiYeUNrGd2Dm2FVVBAiRKq94sx4-CRLOrZnPg3zMTO9EGVcCBw0q764mlzIzH3yQznwl5WQMGbTQVmRbcZdxymtXe0sxQazU1pdUeG4U_fqpOzviHi_Ji46gvrAkL9MBBcfus8JC9AQ5gElI5I6WGDYxKn-daOylD615ej8lUiMGwiqsqNsoxUexHu-ytlq3bg-vZwGa6sREtTNebSNs_BefF6seyuwl5_l5AubEjHd8ldyKUTA_CLWyRW67dJltxsXbp68go_eYeOcSvIJWeQ2aMhS_paBVnU3wSmx5BDMTYh_NBJFpe6fS074aSl6F69ud9cnb87uvRSRYPT8iMqMQ6Y5AKAfgxuil8XvhaaC2lLQAuNDr3tSud59zYnDFvYZ-3JeW-aABfNaV3uWfsAVm0oK4dkgKkkMZUQnvI3QBRasqqWkCUtLSpSmETko2aVKvAkaGGF2UCcougC4WaV1HzCXmL6lZwW-7a6LVCiuvpB35oLqiilWRcJuQQjTJNjLLDH-AkKjqJ-puTJOQZmlSF3tJpUasDXjLITwsqEvJikEBKjBZrbi5133Xq_efzfxA6_TITehWF_BKcw-jY5wAKQKqtmeTuTBIWtpkN76ADjirsVIFdwXhWNIUrR6e8efj5NIyTYh1d65Z9kCmZoLL8g4wEGF9XAKUT8jD4-aR9iuRQkucJEbMVMDPPfKT9_m1gLecSfI-Vj_6HPR-T2wBcK3yrV_Bdslhf9-4JgMN183SIA78A0GleZg
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: ProQuest Central
  dbid: BENPR
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3db9MwELege-EFMb4WGBAQEh9StsR2YucJbdOmgcRAG5v2Zjn-2JAgKU37wH_PXeKEBU0TD5Xa-uq29-Xf2XdnQl6XgEErTUWiBXcJt5wmpbc0MdRaTU1utcdC4c9HxeEp_3Sen4cNtzakVQ4-sXPUtjG4R76dYUkkXpRLP8x_JXhrFJ6uhis0bpM1CpECnZG13f2jr8eDLwZrLopQMMdEth3kszVvarcFCyHruppeWZBmpl2Z0L5_dNKz-Y-mvQ6B_ptIeWVlOrhH7gZIGe_0OrBObrn6PlkPRtvGb0Nn6XcPyC4-Bar4DCJkTICJB-k4G-OObLwHvhB9IM4HHqn5qeOTVdulvnRZtL8fktOD_W97h0m4RCExohDLhEFIBCDI6CrzaeZLobWUNgPYUOnUly53nnNjU8a8hfXe5pT7rAKcVeXepZ6xR2RWA7s2SAzQQhpTCO0hhgNkqSkrSgHe0tKqyIWNSDJwUs37XhmqOzATEGP0vFDIeRU4H5H3yG4Ff8stjF4qbHU9vsAHTQVVtJCMy4jsolDGiZG2e6NZXKhgZYplHkJ9AI1MQtxvpNTwVVT6NNXaSVlG5AWKVPU1pqNxqx2eM4hTMyoi8qqjwNYYNebeXOhV26qPX87-g-jkeEL0JhD5BpTD6FDvAAzAllsTys0JJRi4mQxvoAIOLGzVX1OATw5Kef3wy3EYJ8V8uto1q54mZ4LK_AYaCXC-LABSR-Rxr-cj9yk2iZI8jYiYWMBEPNOR-vtl172cS9A9lj-5-ac_JXcAmhZ4bpfxTTJbLlbuGcC_ZfU82Pgf1t5Y_A
  priority: 102
  providerName: ProQuest
– databaseName: Scholars Portal Journals: Open Access
  dbid: M48
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3rb9MwELdG-cIXxHgtMCAgJB5SqsR2bOcDQtvENJAAibFp3yzHj4E0ktK0EvvvuctLBBW0D5Xa-uy257vz7-p7EPK8AAxaGioTI7lPuOM0KYKjiaXOGWpzZwImCn_8JI5O-Iez_GyLDD1bewY2G1077Cd1sryY__p5-RYU_k3btUFmw6T5oq78HI43lip-jVynWJoLg_n4eK8A2i1En0D3r5mTA2pmm7Xty_mPRnu2uKibTYj078DKP06qw1vkZg8x471OJrbJlq9uk-1eiZv4ZV9p-tUdso9PgSo-BY8ZA2LiYbe8i_Ef2vgAbCPaRFwPLFT9w8TH66YNhWmjai_vkpPDd18PjpK-qUJipZCrhIGLBKDImjILaRYKaYxSLgMYUZo0FD73gXPrUsaCg_Pf5ZSHrATcVebBp4Gxe2RWAbt2SAxQQ1krpAng0wHSNJSJQoL1dLQUuXQRSQZO6kVXO0O3F2gSfI6OFxo5r3vOR-Q1slvDz_JLa1YaS1-PL_BBU0k1FYpxFZF93JRxYaRt36iX57rXOs2yAK4_gEimUi6sUgY-iqqQpsZ4pYqIPMEt1V3O6ajseo_nDPzWjMqIPGspsFRGhbE452bdNPr959MrEB1_mRC96IlCDcJhTZ__AAzAElwTyt0JJSi8nQzvoAAOLGx0htnC2EOawsxBKDcPPx2HcVGMr6t8ve5ociapyv9DowDeFwIgdkTud3I-cp9i0SjF04jIiQZMtmc6Un3_1lYz5wpkj-UPrvDdHpIbgFcFXuZlfJfMVsu1fwSYcFU-btX8N2lSX4Y
  priority: 102
  providerName: Scholars Portal
Title Genetic Variants Associated with Colorectal Adenoma Susceptibility
URI https://www.ncbi.nlm.nih.gov/pubmed/27078840
https://www.proquest.com/docview/1781154732
https://search.proquest.com/docview/1781537285
https://search.proquest.com/docview/1805496551
https://recercat.cat/handle/2072/268348
https://pubmed.ncbi.nlm.nih.gov/PMC4831735
https://doaj.org/article/31f74295138046c88a01528f00aae889
http://dx.doi.org/10.1371/journal.pone.0153084
Volume 11
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3db9MwELe28sILYnwtMEpASHxIaRM7iZ3HtWoZSB3Txqa9WY4db5PWpGraB17427nLlxY0IcRDraa-uO2d7_w75-5MyPsEMGiqKPcUDzMvNCH1Emuop6kxiurIKIuJwovj-Og8_HYZXe6QqM2FqYL2dXozym-Xo_zmuoqtXC31uI0TG58spqGAVY9F412yCxO0ddFr8wsKHMdNjhzjwbgRyWhV5NkI1j7mCzyLh2KVG4FbHneWo4Eut7op3t-Z6MHqtijvw59_hlHeWZfmj8mjBlC6h_UP3yM7Wf6E7DUqW7ofm7rSn56SCb4FKvcC_GMMf3Fb2WTGxf1YdwqWEC0gjgf2qFgq92xbVoEvVQztz2fkfD77MT3ymiMUPM1jvvEYOEQAgbRKA-sHNuFKCWECYF-qfJtkUWbDUBufMWtgtTcRDW2QAspKI5v5lrHnZJAD5_aJC8BCaB1zZcGDA1ypKIsTDrbS0DSOuHGI13JSrupKGbJ6XMbBw6h5IVEIshGCQz4juyX8rWyt1UZioevuAl_U51TSWLBQOGSCQukGRtrqg2J9JZupIVlgwdEHyMgEeP1aCAVfRYX1faUyIRKHvEGRyjrDtFNteRhGDLzUgHKHvKsosDBGjpE3V2pblvLr94t_IDo77RF9aIhsAZNDqybbARiABbd6lAc9SlBv3evexwnYsrCUAeYG44nRFO5sJ-X93W-7bhwUo-nyrNjWNBHjVER_oREA5pMYALVDXtTzvON-qzwO4T0N6Imn3wOqXNUub1T35X_f-Yo8BMwa4wO9IDwgg816m70GXLhJh2ANLjm0YhpgO_8yJA8ms-OT02G10wLtIhTY_poNK5vxGwmiZ88
link.rule.ids 230,315,730,783,787,867,888,2109,2228,12070,12237,12779,21402,24332,27938,27939,31733,31734,33280,33281,33387,33388,33758,33759,43324,43593,43614,43819,53806,53808,74081,74350,74371,74638
linkProvider National Library of Medicine
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3db9MwELegPMALYnwtMFhASHxI2RLbiZ0ntE2UDrYhsQ_tzXLseCBBUpr2gf-eu8QJC5omHiq19dVtz_fxO_vuTMirHDBooamItOBlxC2nUe4sjQy1VlOTWu2wUPjwKJud8k_n6bnfcGt8WmVvE1tDbWuDe-TbCZZE4kW59P38V4S3RuHpqr9C4ya5xRk4GqwUn37sLTHocpb5cjkmkm2_Olvzuiq3wA2ytqfpJXc0Mc3K-Ob9g4mezH_UzVX48980ykt-aXqP3PWAMtzpJGCN3Cir-2TNq2wTvvF9pd8-ILv4FKjCM4iPMf0l7NemtCHux4Z7YAnRAuJ8YI_qnzo8XjVt4kubQ_v7ITmdfjjZm0X-CoXIiEwsIwYBEUAgo4vExYnLhdZS2gRAQ6Fjl5dp6Tg3NmbMWfD2NqXcJQWgrCJ1ZewYe0QmFbBrnYQALKQxmdAOIjjAlZqyLBdgKy0tslTYgEQ9J9W865Sh2uMyARFGxwuFnFee8wF5h-xW8LfKhdFLhY2uhxf4oLGgimaScRmQXVyUYWKkbd-oFxfK65hiiYNAHyAjkxD1Gyk1fBWVLo61LqXMA7KJS6q6CtNBtdUOTxlEqQkVAXnZUmBjjAozby70qmnU_pez_yA6_joieu2JXA3CYbSvdgAGYMOtEeXGiBLU24yG11EAexY26q8iwCd7obx6-MUwjJNiNl1V1quOJmWCyvQaGglgPs8AUAfkcSfnA_cptoiSPA6IGGnAaHnGI9X3b23vci5B9lj65Pqfvkluz04OD9TB_tHnp-QOgNQMT_ASvkEmy8WqfAZAcFk8b7X9D35tWoc
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3db9MwELegSIgXxPhaYLCAkPiQsia2EztPaBtUGx8DMTb1zXLseCBBUprmgf-eu8QNC5omHiq19dVNzvfxu_juTMizHDBooamItOBlxC2nUe4sjQy1VlOTWu2wUPjjUXZwwt_N07nPf2p8WuXaJnaG2tYGn5FPEyyJxINy6dT5tIjPb2avF78iPEEKd1r9cRpXyTXBwdGBbIv5EHyBXmeZL51jIpn6ldpZ1FW5Ay6Rdf1Nz7mmiWla4xv5D-Z6svhRNxdh0X9TKs_5qNktctODy3C3l4YNcqWsbpMNr75N-ML3mH55h-zhW6AKTyFWxlSYcL1OpQ3x2Wy4D1YRrSHOB7ap_qnD47bpkmC6fNrfd8nJ7O3X_YPIH6cQGZGJVcQgOAI4ZHSRuDhxudBaSpsAgCh07PIyLR3nxsaMOQue36aUu6QAxFWkrowdY_fIpAJ2bZIQQIY0JhPaQTQHGFNTluUC7KalRZYKG5BozUm16LtmqG7rTEC00fNCIeeV53xAXiG7FdxWuTR6pbDp9fABXzQWVNFMMi4DsoeLMkyMtN0X9fJMeX1TLHEQ9AN8ZDLmmZFSw19R6eJY61LKPCDbuKSqrzYd1Fzt8pRBxJpQEZCnHQU2yahQ3M502zTq8NPpfxAdfxkRPfdErgbhMNpXPgADsPnWiHJrRAmqbkbDmyiAaxY26q9SwC_XQnnx8JNhGCfFzLqqrNueJmWCyvQSGgnAPs8AXAfkfi_nA_cptouSPA6IGGnAaHnGI9X3b10fcy5B9lj64PJL3ybXQdHVh8Oj9w_JDcCrGW7mJXyLTFbLtnwEmHBVPO6U_Q8RBV68
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Genetic+Variants+Associated+with+Colorectal+Adenoma+Susceptibility&rft.jtitle=PloS+one&rft.au=Abul%C3%AD%2C+Anna&rft.au=Castells%2C+Antoni&rft.au=Bujanda%2C+Luis&rft.au=Lozano%2C+Juan+Jos%C3%A9&rft.date=2016-04-14&rft.eissn=1932-6203&rft.volume=11&rft.issue=4&rft.spage=e0153084&rft.epage=e0153084&rft_id=info:doi/10.1371%2Fjournal.pone.0153084&rft.externalDBID=NO_FULL_TEXT
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1932-6203&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1932-6203&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1932-6203&client=summon