Recent developments in yeast aging

• Published in: PLoS genetics Vol. 3; no. 5; p. e84
• Main Authors: Kaeberlein, Matt, Burtner, Christopher R, Kennedy, Brian K
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.05.2007; Public Library of Science (PLoS)
• Subjects: Aging; Animals; Apoptosis; Cell Biology; Chemical properties; Eukaryotes; Genetic aspects; Genetic research; Genetics and Genomics; Genome, Fungal - genetics; Histone Deacetylases - metabolism; Humans; Kinases; Molecular Biology; Nutrition; Oxidative Stress; Proteins; Review; Saccharomyces; Saccharomyces cerevisiae - cytology; Saccharomyces cerevisiae - enzymology; Saccharomyces cerevisiae - genetics; Saccharomyces cerevisiae - physiology; Silent Information Regulator Proteins, Saccharomyces cerevisiae - metabolism; Sirtuin 2; Sirtuins - metabolism; Time Factors; Yeast; Yeast fungi; United States
• ISSN: 1553-7404; 1553-7390; 1553-7404
• DOI: 10.1371/journal.pgen.0030084

In the last decade, research into the molecular determinants of aging has progressed rapidly and much of this progress can be attributed to studies in invertebrate eukaryotic model organisms. Of these, single-celled yeast is the least complicated and most amenable to genetic and molecular manipulations. Supporting the use of this organism for aging research, increasing evidence has accumulated that a subset of pathways influencing longevity in yeast are conserved in other eukaryotes, including mammals. Here we briefly outline aging in yeast and describe recent findings that continue to keep this "simple" eukaryote at the forefront of aging research.