Age and sex differences in soluble ACE2 may give insights for COVID-19

SEE PDF] There was similar and low sACE2 in both sexes up to age 12. sACE2 increased more in boys with growth, so men from age 15 had higher sACE2 than women (Fig. 1). [...]sACE2 is low in children and increases more in boys than girls, resulting in sex differences in adolescence/young adulthood. Hi...

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Published inCritical care (London, England) Vol. 24; no. 1; pp. 221 - 3
Main Authors Swärd, Per, Edsfeldt, Andreas, Reepalu, Anton, Jehpsson, Lars, Rosengren, Björn E., Karlsson, Magnus K.
Format Journal Article
LanguageEnglish
Published London BioMed Central 14.05.2020
BioMed Central Ltd
BMC
Subjects
Adolescent
Adults
Age Factors
Age groups
Angiotensin-Converting Enzyme 2
Child
Clinical Medicine
Coronavirus Infections - enzymology
Coronaviruses
COVID-19
Critical care
Critical Care Medicine
Emergency Medicine
Enzymes
Female
Gender differences
Humans
Infectious Medicine
Infektionsmedicin
Intensive
Klinisk medicin
Male
Medical and Health Sciences
Medicin och hälsovetenskap
Medicine
Medicine & Public Health
Osteoporosis
Pandemics
Pediatrics
Peptidyl-Dipeptidase A - blood
Peptidyl-Dipeptidase A - chemistry
Physiological aspects
Pneumonia, Viral - enzymology
Protein expression
Proteins
Research Letter
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Sex Factors
Solubility
Young Adult
Sweden
Online AccessGet full text
ISSN1364-8535
1466-609X
1364-8535
1466-609X
1366-609X
DOI10.1186/s13054-020-02942-2

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Abstract SEE PDF] There was similar and low sACE2 in both sexes up to age 12. sACE2 increased more in boys with growth, so men from age 15 had higher sACE2 than women (Fig. 1). [...]sACE2 is low in children and increases more in boys than girls, resulting in sex differences in adolescence/young adulthood. High mACE2 and/or high ADAM-17 activity may therefore be risk factors for severe COVID-19 [1, 2]. Since high sACE2 could indicate high mACE2 and/or high ADAM-17 activity, sACE2 may be a marker of both susceptibility and severity of COVID-19. [...]this study shows that subjects with higher risk for severe COVID-19 [4] had higher sACE2 (adults>children and men>women).
AbstractList SEE PDF] There was similar and low sACE2 in both sexes up to age 12. sACE2 increased more in boys with growth, so men from age 15 had higher sACE2 than women (Fig. 1). [...]sACE2 is low in children and increases more in boys than girls, resulting in sex differences in adolescence/young adulthood. High mACE2 and/or high ADAM-17 activity may therefore be risk factors for severe COVID-19 [1, 2]. Since high sACE2 could indicate high mACE2 and/or high ADAM-17 activity, sACE2 may be a marker of both susceptibility and severity of COVID-19. [...]this study shows that subjects with higher risk for severe COVID-19 [4] had higher sACE2 (adults>children and men>women).
ArticleNumber 221
Audience Academic
Author Karlsson, Magnus K.
Rosengren, Björn E.
Edsfeldt, Andreas
Jehpsson, Lars
Swärd, Per
Reepalu, Anton
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  surname: Karlsson
  fullname: Karlsson, Magnus K.
  organization: Clinical and Molecular Osteoporosis Research Unit, Departments of Orthopedics and Clinical Sciences, Skåne University Hospital, Lund University
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Copyright The Author(s) 2020
COPYRIGHT 2020 BioMed Central Ltd.
2020. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
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Institutionen för translationell medicin
Department of Translational Medicine
Lunds universitet
Profile areas and other strong research environments
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Orthopedics
EXODIAB: Excellence of Diabetes Research in Sweden
Faculty of Medicine
Cardiovascular Research - Translational Studies
Kardiovaskulär forskning - translationella studier
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Medicinska fakulteten
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Institutionen för kliniska vetenskaper, Malmö
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  issue: 4
  year: 2020
  ident: 2942_CR1
  publication-title: Intensive Care Med
  doi: 10.1007/s00134-020-05985-9
– reference: 32631373 - Crit Care. 2020 Jul 6;24(1):396
SSID ssj0017863
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Snippet SEE PDF] There was similar and low sACE2 in both sexes up to age 12. sACE2 increased more in boys with growth, so men from age 15 had higher sACE2 than women...
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StartPage 221
SubjectTerms Adolescent
Adults
Age Factors
Age groups
Angiotensin-Converting Enzyme 2
Child
Clinical Medicine
Coronavirus Infections - enzymology
Coronaviruses
COVID-19
Critical care
Critical Care Medicine
Emergency Medicine
Enzymes
Female
Gender differences
Humans
Infectious Medicine
Infektionsmedicin
Intensive
Klinisk medicin
Male
Medical and Health Sciences
Medicin och hälsovetenskap
Medicine
Medicine & Public Health
Osteoporosis
Pandemics
Pediatrics
Peptidyl-Dipeptidase A - blood
Peptidyl-Dipeptidase A - chemistry
Physiological aspects
Pneumonia, Viral - enzymology
Protein expression
Proteins
Research Letter
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Sex Factors
Solubility
Young Adult
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Title Age and sex differences in soluble ACE2 may give insights for COVID-19
URI https://link.springer.com/article/10.1186/s13054-020-02942-2
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Volume 24
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