The effect of duration of illness and antipsychotics on subcortical volumes in schizophrenia: Analysis of 778 subjects

• Published in: NeuroImage clinical Vol. 17; no. 17; pp. 563 - 569
• Main Authors: Hashimoto, Naoki, Ito, Yoichi M., Okada, Naohiro, Yamamori, Hidenaga, Yasuda, Yuka, Fujimoto, Michiko, Kudo, Noriko, Takemura, Ariyoshi, Son, Shuraku, Narita, Hisashi, Yamamoto, Maeri, Tha, Khin Khin, Katsuki, Asuka, Ohi, Kazutaka, Yamashita, Fumio, Koike, Shinsuke, Takahashi, Tsutomu, Nemoto, Kiyotaka, Fukunaga, Masaki, Onitsuka, Toshiaki, Watanabe, Yoshiyuki, Yamasue, Hidenori, Suzuki, Michio, Kasai, Kiyoto, Kusumi, Ichiro, Hashimoto, Ryota
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.01.2018; Elsevier
• Subjects: Adult; Age of Onset; Antipsychotic; Antipsychotic Agents - therapeutic use; Brain - pathology; Duration of illness; Female; Globus pallidus; Hippocampus; Humans; Magnetic Resonance Imaging; Male; Meta-Analysis as Topic; MRI; Radiology; Regular; Schizophrenia; Schizophrenia - drug therapy; Schizophrenia - pathology; Young Adult; Schizophrenia; Globus pallidus; Antipsychotic; Duration of illness; MRI; Hippocampus

The effect of duration of illness and antipsychotic medication on the volumes of subcortical structures in schizophrenia is inconsistent among previous reports. We implemented a large sample analysis utilizing clinical data from 11 institutions in a previous meta-analysis. Imaging and clinical data...