The relationship between knee joint loading rate during walking and degenerative changes on magnetic resonance imaging
While animal study and cadaveric study have demonstrated an association between knee joint loading rate and joint degeneration, the relationship between knee joint loading rate during walking and osteoarthritis has not yet been sufficiently studied in humans. Twenty-eight participants (14 transfemor...
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| Published in | Clinical biomechanics (Bristol) Vol. 29; no. 6; pp. 664 - 670 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Elsevier Ltd
01.06.2014
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0268-0033 1879-1271 1879-1271 |
| DOI | 10.1016/j.clinbiomech.2014.04.008 |
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| Abstract | While animal study and cadaveric study have demonstrated an association between knee joint loading rate and joint degeneration, the relationship between knee joint loading rate during walking and osteoarthritis has not yet been sufficiently studied in humans.
Twenty-eight participants (14 transfemoral amputees and 14 age and body mass matched controls) underwent knee MRI with subsequent assessment using the semiquantitative Whole-Organ Magnetic Resonance Image Score. Each subject also underwent gait analysis in order to determine knee adduction moment loading rate, peak, and impulse and an exploratory measure, knee adduction moment rate∗magnitude.
Significant correlations were found between medial tibiofemoral joint degeneration and knee adduction moment peak (slope=0.42 [SE 0.20]; P=.037), loading rate (slope=12.3 [SE 3.2]; P=.0004), and rate∗magnitude (slope=437 [SE 100]; P<.0001). These relationships continued to be significant after adjusting for body mass or subject type. The relationship between medial knee semiquantitative MRI score and knee adduction moment loading rate and rate∗magnitude continued to be significant even after adjusting for peak moment (P<.0001), however, the relationship between medial knee semiquantitative MRI score and peak moment was no longer significant after adjusting for either loading rate or rate∗magnitude (P>.2 in both cases).
This study suggests an independent relationship between knee adduction moment loading rate and medial tibiofemoral joint degeneration. Our results support the hypothesis that rate of loading, represented by the knee adduction moment loading rate, is strongly associated with medial tibiofemoral joint degeneration independent of knee adduction moment peak and impulse. |
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| AbstractList | Abstract Background While animal study and cadaveric study have demonstrated an association between knee joint loading rate and joint degeneration, the relationship between knee joint loading rate during walking and osteoarthritis has not yet been sufficiently studied in humans. Methods Twenty-eight participants (14 transfemoral amputees and 14 age and body mass matched controls) underwent knee MRI with subsequent assessment using the semiquantitative Whole-Organ Magnetic Resonance Image Score. Each subject also underwent gait analysis in order to determine knee adduction moment loading rate, peak, and impulse and an exploratory measure, knee adduction moment rate ∗ magnitude. Findings Significant correlations were found between medial tibiofemoral joint degeneration and knee adduction moment peak (slope = 0.42 [SE 0.20]; P = .037), loading rate (slope = 12.3 [SE 3.2]; P = .0004), and rate ∗ magnitude (slope = 437 [SE 100]; P < .0001). These relationships continued to be significant after adjusting for body mass or subject type. The relationship between medial knee semiquantitative MRI score and knee adduction moment loading rate and rate ∗ magnitude continued to be significant even after adjusting for peak moment ( P < .0001), however, the relationship between medial knee semiquantitative MRI score and peak moment was no longer significant after adjusting for either loading rate or rate ∗ magnitude ( P > .2 in both cases). Interpretation This study suggests an independent relationship between knee adduction moment loading rate and medial tibiofemoral joint degeneration. Our results support the hypothesis that rate of loading, represented by the knee adduction moment loading rate, is strongly associated with medial tibiofemoral joint degeneration independent of knee adduction moment peak and impulse. While animal study and cadaveric study have demonstrated an association between knee joint loading rate and joint degeneration, the relationship between knee joint loading rate during walking and osteoarthritis has not yet been sufficiently studied in humans. Twenty-eight participants (14 transfemoral amputees and 14 age and body mass matched controls) underwent knee MRI with subsequent assessment using the semiquantitative Whole-Organ Magnetic Resonance Image Score. Each subject also underwent gait analysis in order to determine knee adduction moment loading rate, peak, and impulse and an exploratory measure, knee adduction moment rate∗magnitude. Significant correlations were found between medial tibiofemoral joint degeneration and knee adduction moment peak (slope=0.42 [SE 0.20]; P=.037), loading rate (slope=12.3 [SE 3.2]; P=.0004), and rate∗magnitude (slope=437 [SE 100]; P<.0001). These relationships continued to be significant after adjusting for body mass or subject type. The relationship between medial knee semiquantitative MRI score and knee adduction moment loading rate and rate∗magnitude continued to be significant even after adjusting for peak moment (P<.0001), however, the relationship between medial knee semiquantitative MRI score and peak moment was no longer significant after adjusting for either loading rate or rate∗magnitude (P>.2 in both cases). This study suggests an independent relationship between knee adduction moment loading rate and medial tibiofemoral joint degeneration. Our results support the hypothesis that rate of loading, represented by the knee adduction moment loading rate, is strongly associated with medial tibiofemoral joint degeneration independent of knee adduction moment peak and impulse. While animal study and cadaveric study have demonstrated an association between knee joint loading rate and joint degeneration, the relationship between knee joint loading rate during walking and osteoarthritis has not yet been sufficiently studied in humans.BACKGROUNDWhile animal study and cadaveric study have demonstrated an association between knee joint loading rate and joint degeneration, the relationship between knee joint loading rate during walking and osteoarthritis has not yet been sufficiently studied in humans.Twenty-eight participants (14 transfemoral amputees and 14 age and body mass matched controls) underwent knee MRI with subsequent assessment using the semiquantitative Whole-Organ Magnetic Resonance Image Score. Each subject also underwent gait analysis in order to determine knee adduction moment loading rate, peak, and impulse and an exploratory measure, knee adduction moment rate∗magnitude.METHODSTwenty-eight participants (14 transfemoral amputees and 14 age and body mass matched controls) underwent knee MRI with subsequent assessment using the semiquantitative Whole-Organ Magnetic Resonance Image Score. Each subject also underwent gait analysis in order to determine knee adduction moment loading rate, peak, and impulse and an exploratory measure, knee adduction moment rate∗magnitude.Significant correlations were found between medial tibiofemoral joint degeneration and knee adduction moment peak (slope=0.42 [SE 0.20]; P=.037), loading rate (slope=12.3 [SE 3.2]; P=.0004), and rate∗magnitude (slope=437 [SE 100]; P<.0001). These relationships continued to be significant after adjusting for body mass or subject type. The relationship between medial knee semiquantitative MRI score and knee adduction moment loading rate and rate∗magnitude continued to be significant even after adjusting for peak moment (P<.0001), however, the relationship between medial knee semiquantitative MRI score and peak moment was no longer significant after adjusting for either loading rate or rate∗magnitude (P>.2 in both cases).FINDINGSSignificant correlations were found between medial tibiofemoral joint degeneration and knee adduction moment peak (slope=0.42 [SE 0.20]; P=.037), loading rate (slope=12.3 [SE 3.2]; P=.0004), and rate∗magnitude (slope=437 [SE 100]; P<.0001). These relationships continued to be significant after adjusting for body mass or subject type. The relationship between medial knee semiquantitative MRI score and knee adduction moment loading rate and rate∗magnitude continued to be significant even after adjusting for peak moment (P<.0001), however, the relationship between medial knee semiquantitative MRI score and peak moment was no longer significant after adjusting for either loading rate or rate∗magnitude (P>.2 in both cases).This study suggests an independent relationship between knee adduction moment loading rate and medial tibiofemoral joint degeneration. Our results support the hypothesis that rate of loading, represented by the knee adduction moment loading rate, is strongly associated with medial tibiofemoral joint degeneration independent of knee adduction moment peak and impulse.INTERPRETATIONThis study suggests an independent relationship between knee adduction moment loading rate and medial tibiofemoral joint degeneration. Our results support the hypothesis that rate of loading, represented by the knee adduction moment loading rate, is strongly associated with medial tibiofemoral joint degeneration independent of knee adduction moment peak and impulse. |
| Author | Seyedali, Mahyo Morgenroth, David C. Czerniecki, Joseph M. Medverd, Jonathan R. |
| AuthorAffiliation | 2 Department of Radiology, VAPSHCS Department of Veterans Affairs, Seattle, WA, USA 4 Department of Radiology, University of Washington, Seattle, WA, USA 1 Rehabilitation Research and Development Center of Excellence, VAPSHCS, Department of Veterans Affairs, Seattle, WA, USA 3 Department of Rehabiltiation Medicine, University of Washington, Seattle, WA, USA |
| AuthorAffiliation_xml | – name: 1 Rehabilitation Research and Development Center of Excellence, VAPSHCS, Department of Veterans Affairs, Seattle, WA, USA – name: 3 Department of Rehabiltiation Medicine, University of Washington, Seattle, WA, USA – name: 4 Department of Radiology, University of Washington, Seattle, WA, USA – name: 2 Department of Radiology, VAPSHCS Department of Veterans Affairs, Seattle, WA, USA |
| Author_xml | – sequence: 1 givenname: David C. surname: Morgenroth fullname: Morgenroth, David C. email: dmorgen@uw.edu organization: Rehabilitation Research and Development Center of Excellence, VAPSHCS, Department of Veterans Affairs, Seattle, WA, USA – sequence: 2 givenname: Jonathan R. surname: Medverd fullname: Medverd, Jonathan R. organization: Department of Radiology, VAPSHCS, Department of Veterans Affairs, Seattle, WA, USA – sequence: 3 givenname: Mahyo surname: Seyedali fullname: Seyedali, Mahyo organization: Rehabilitation Research and Development Center of Excellence, VAPSHCS, Department of Veterans Affairs, Seattle, WA, USA – sequence: 4 givenname: Joseph M. surname: Czerniecki fullname: Czerniecki, Joseph M. organization: Rehabilitation Research and Development Center of Excellence, VAPSHCS, Department of Veterans Affairs, Seattle, WA, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/24820134$$D View this record in MEDLINE/PubMed |
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| Snippet | While animal study and cadaveric study have demonstrated an association between knee joint loading rate and joint degeneration, the relationship between knee... Abstract Background While animal study and cadaveric study have demonstrated an association between knee joint loading rate and joint degeneration, the... |
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| SubjectTerms | Adult Amputees Case-Control Studies Cross-Sectional Studies Femur Gait Gait - physiology Humans Knee Knee Joint - pathology Knee Joint - physiopathology Magnetic Resonance Imaging - methods Male Middle Aged Orthotic Devices Osteoarthritis Osteoarthritis - pathology Osteoarthritis, Knee - pathology Osteoarthritis, Knee - physiopathology Physical Medicine and Rehabilitation Tibia Walking - physiology Weight-Bearing - physiology |
| Title | The relationship between knee joint loading rate during walking and degenerative changes on magnetic resonance imaging |
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