Comparative Analysis of Measures of Viral Reservoirs in HIV-1 Eradication Studies

• Published in: PLoS pathogens Vol. 9; no. 2; p. e1003174
• Main Authors: Eriksson, Susanne, Graf, Erin H., Dahl, Viktor, Strain, Matthew C., Yukl, Steven A., Lysenko, Elena S., Bosch, Ronald J., Lai, Jun, Chioma, Stanley, Emad, Fatemeh, Abdel-Mohsen, Mohamed, Hoh, Rebecca, Hecht, Frederick, Hunt, Peter, Somsouk, Ma, Wong, Joseph, Johnston, Rowena, Siliciano, Robert F., Richman, Douglas D., O'Doherty, Una, Palmer, Sarah, Deeks, Steven G., Siliciano, Janet D.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.02.2013; Public Library of Science (PLoS)
• Subjects: Acquired immune deficiency syndrome; Adult; Aged; AIDS; Antiretroviral agents; Antiretroviral Therapy, Highly Active; CD4-Positive T-Lymphocytes - drug effects; Clinical trials; Deoxyribonucleic acid; Disease Reservoirs - virology; DNA; DNA, Viral - analysis; DNA, Viral - drug effects; DNA, Viral - genetics; Drug therapy; Experiments; Female; Genomes; Grants; Health aspects; HIV; HIV - genetics; HIV - growth & development; HIV - isolation & purification; HIV Infections - drug therapy; HIV Infections - genetics; HIV Infections - virology; HIV patients; Human immunodeficiency virus; Humans; Infections; Leukocytes, Mononuclear - drug effects; Leukocytes, Mononuclear - virology; Longitudinal Studies; Lymphocytes; Male; Medicine; Middle Aged; Normal distribution; Physiological aspects; Plasma; Polymerase Chain Reaction; Proviruses - genetics; Proviruses - growth & development; Proviruses - isolation & purification; RNA, Viral - analysis; RNA, Viral - drug effects; RNA, Viral - genetics; Statistical methods; T cells; Viral Load - drug effects; Virulence (Microbiology); Virus Integration - drug effects; United States

HIV-1 reservoirs preclude virus eradication in patients receiving highly active antiretroviral therapy (HAART). The best characterized reservoir is a small, difficult-to-quantify pool of resting memory CD4(+) T cells carrying latent but replication-competent viral genomes. Because strategies targeti...