Flow cytometry-based diagnosis of primary immunodeficiency diseases

• Published in: Allergology International Vol. 67; no. 1; pp. 43 - 54
• Main Authors: Kanegane, Hirokazu, Hoshino, Akihiro, Okano, Tsubasa, Yasumi, Takahiro, Wada, Taizo, Takada, Hidetoshi, Okada, Satoshi, Yamashita, Motoi, Yeh, Tzu-wen, Nishikomori, Ryuta, Takagi, Masatoshi, Imai, Kohsuke, Ochs, Hans D., Morio, Tomohiro
• Format: Journal Article
• Language: English
• Published: England Elsevier B.V 01.01.2018; JAPANESE SOCIETY OF ALLERGOLOGY; Elsevier
• Subjects: Flow cytometry; Intracellular protein; Monoclonal antibody; Primary immunodeficiency disease; Surface protein; CD40L; DOCK8; HIGM; DNT; X-SCID; MyD88; TNF; BAFF-R; PNP; Th; CTLA4; MSMD; Surface protein; JAK3; APECED; iNKT; NOD; IRAK4; FOXP3; ZAP70; BTK; IPEX; Intracellular protein; Flow cytometry; TCR; SAP; CTLs; WAS; XIAP; Monoclonal antibody; FHL; XLA; PIDs; SCID; HIES; LPS; DHR; IFN; CVID; CMCD; Primary immunodeficiency disease; TLR; ICOS; XLP; CGD; XLT; LRBA; PBMCs; LAD; mAb; WASp; ALPS; STAT; RAG; ADA

Primary immunodeficiencies (PIDs) are a heterogeneous group of inherited diseases of the immune system. The definite diagnosis of PID is ascertained by genetic analysis; however, this takes time and is costly. Flow cytometry provides a rapid and highly sensitive tool for diagnosis of PIDs. Flow cyto...