Cerebrospinal fluid p-tau217 performs better than p-tau181 as a biomarker of Alzheimer’s disease
Cerebrospinal fluid (CSF) p-tau181 (tau phosphorylated at threonine 181) is an established biomarker of Alzheimer’s disease (AD), reflecting abnormal tau metabolism in the brain. Here we investigate the performance of CSF p-tau217 as a biomarker of AD in comparison to p-tau181. In the Swedish BioFIN...
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| Published in | Nature communications Vol. 11; no. 1; pp. 1683 - 12 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group UK
03.04.2020
Nature Publishing Group Nature Portfolio |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Cerebrospinal fluid (CSF) p-tau181 (tau phosphorylated at threonine 181) is an established biomarker of Alzheimer’s disease (AD), reflecting abnormal tau metabolism in the brain. Here we investigate the performance of CSF p-tau217 as a biomarker of AD in comparison to p-tau181. In the Swedish BioFINDER cohort (
n
= 194), p-tau217 shows stronger correlations with the tau positron emission tomography (PET) tracer [
18
F]flortaucipir, and more accurately identifies individuals with abnormally increased [
18
F]flortaucipir retention. Furthermore, longitudinal increases in p-tau217 are higher compared to p-tau181 and better correlate with [
18
F]flortaucipir uptake. P-tau217 correlates better than p-tau181 with CSF and PET measures of neocortical amyloid-β burden and more accurately distinguishes AD dementia from non-AD neurodegenerative disorders. Higher correlations between p-tau217 and [
18
F]flortaucipir are corroborated in an independent EXPEDITION3 trial cohort (
n
= 32). The main results are validated using a different p-tau217 immunoassay. These findings suggest that p-tau217 might be more useful than p-tau181 in the diagnostic work up of AD.
Cerebrospinal fluid (CSF) p-tau181 (tau phosphorylated at threonine 181) is an established biomarker of Alzheimer’s disease (AD) reflecting abnormal tau metabolism in the AD brain. Here the authors demonstrate that CSF p-tau217 shows better performance as an AD biomarker than p-tau181. |
|---|---|
| AbstractList | Cerebrospinal fluid (CSF) p-tau181 (tau phosphorylated at threonine 181) is an established biomarker of Alzheimer’s disease (AD), reflecting abnormal tau metabolism in the brain. Here we investigate the performance of CSF p-tau217 as a biomarker of AD in comparison to p-tau181. In the Swedish BioFINDER cohort (n = 194), p-tau217 shows stronger correlations with the tau positron emission tomography (PET) tracer [18F]flortaucipir, and more accurately identifies individuals with abnormally increased [18F]flortaucipir retention. Furthermore, longitudinal increases in p-tau217 are higher compared to p-tau181 and better correlate with [18F]flortaucipir uptake. P-tau217 correlates better than p-tau181 with CSF and PET measures of neocortical amyloid-β burden and more accurately distinguishes AD dementia from non-AD neurodegenerative disorders. Higher correlations between p-tau217 and [18F]flortaucipir are corroborated in an independent EXPEDITION3 trial cohort (n = 32). The main results are validated using a different p-tau217 immunoassay. These findings suggest that p-tau217 might be more useful than p-tau181 in the diagnostic work up of AD. Cerebrospinal fluid (CSF) p-tau181 (tau phosphorylated at threonine 181) is an established biomarker of Alzheimer’s disease (AD), reflecting abnormal tau metabolism in the brain. Here we investigate the performance of CSF p-tau217 as a biomarker of AD in comparison to p-tau181. In the Swedish BioFINDER cohort ( n = 194), p-tau217 shows stronger correlations with the tau positron emission tomography (PET) tracer [ 18 F]flortaucipir, and more accurately identifies individuals with abnormally increased [ 18 F]flortaucipir retention. Furthermore, longitudinal increases in p-tau217 are higher compared to p-tau181 and better correlate with [ 18 F]flortaucipir uptake. P-tau217 correlates better than p-tau181 with CSF and PET measures of neocortical amyloid-β burden and more accurately distinguishes AD dementia from non-AD neurodegenerative disorders. Higher correlations between p-tau217 and [ 18 F]flortaucipir are corroborated in an independent EXPEDITION3 trial cohort ( n = 32). The main results are validated using a different p-tau217 immunoassay. These findings suggest that p-tau217 might be more useful than p-tau181 in the diagnostic work up of AD. Cerebrospinal fluid (CSF) p-tau181 (tau phosphorylated at threonine 181) is an established biomarker of Alzheimer’s disease (AD) reflecting abnormal tau metabolism in the AD brain. Here the authors demonstrate that CSF p-tau217 shows better performance as an AD biomarker than p-tau181. Cerebrospinal fluid (CSF) p-tau181 (tau phosphorylated at threonine 181) is an established biomarker of Alzheimer’s disease (AD), reflecting abnormal tau metabolism in the brain. Here we investigate the performance of CSF p-tau217 as a biomarker of AD in comparison to p-tau181. In the Swedish BioFINDER cohort (n = 194), p-tau217 shows stronger correlations with the tau positron emission tomography (PET) tracer [18F]flortaucipir, and more accurately identifies individuals with abnormally increased [18F]flortaucipir retention. Furthermore, longitudinal increases in p-tau217 are higher compared to p-tau181 and better correlate with [18F]flortaucipir uptake. P-tau217 correlates better than p-tau181 with CSF and PET measures of neocortical amyloid-β burden and more accurately distinguishes AD dementia from non-AD neurodegenerative disorders. Higher correlations between p-tau217 and [18F]flortaucipir are corroborated in an independent EXPEDITION3 trial cohort (n = 32). The main results are validated using a different p-tau217 immunoassay. These findings suggest that p-tau217 might be more useful than p-tau181 in the diagnostic work up of AD.Cerebrospinal fluid (CSF) p-tau181 (tau phosphorylated at threonine 181) is an established biomarker of Alzheimer’s disease (AD) reflecting abnormal tau metabolism in the AD brain. Here the authors demonstrate that CSF p-tau217 shows better performance as an AD biomarker than p-tau181. Cerebrospinal fluid (CSF) p-tau181 (tau phosphorylated at threonine 181) is an established biomarker of Alzheimer’s disease (AD) reflecting abnormal tau metabolism in the AD brain. Here the authors demonstrate that CSF p-tau217 shows better performance as an AD biomarker than p-tau181. Cerebrospinal fluid (CSF) p-tau181 (tau phosphorylated at threonine 181) is an established biomarker of Alzheimer's disease (AD), reflecting abnormal tau metabolism in the brain. Here we investigate the performance of CSF p-tau217 as a biomarker of AD in comparison to p-tau181. In the Swedish BioFINDER cohort (n = 194), p-tau217 shows stronger correlations with the tau positron emission tomography (PET) tracer [ F]flortaucipir, and more accurately identifies individuals with abnormally increased [ F]flortaucipir retention. Furthermore, longitudinal increases in p-tau217 are higher compared to p-tau181 and better correlate with [ F]flortaucipir uptake. P-tau217 correlates better than p-tau181 with CSF and PET measures of neocortical amyloid-β burden and more accurately distinguishes AD dementia from non-AD neurodegenerative disorders. Higher correlations between p-tau217 and [ F]flortaucipir are corroborated in an independent EXPEDITION3 trial cohort (n = 32). The main results are validated using a different p-tau217 immunoassay. These findings suggest that p-tau217 might be more useful than p-tau181 in the diagnostic work up of AD. Cerebrospinal fluid (CSF) p-tau181 (tau phosphorylated at threonine 181) is an established biomarker of Alzheimer's disease (AD), reflecting abnormal tau metabolism in the brain. Here we investigate the performance of CSF p-tau217 as a biomarker of AD in comparison to p-tau181. In the Swedish BioFINDER cohort (n = 194), p-tau217 shows stronger correlations with the tau positron emission tomography (PET) tracer [18F]flortaucipir, and more accurately identifies individuals with abnormally increased [18F]flortaucipir retention. Furthermore, longitudinal increases in p-tau217 are higher compared to p-tau181 and better correlate with [18F]flortaucipir uptake. P-tau217 correlates better than p-tau181 with CSF and PET measures of neocortical amyloid-β burden and more accurately distinguishes AD dementia from non-AD neurodegenerative disorders. Higher correlations between p-tau217 and [18F]flortaucipir are corroborated in an independent EXPEDITION3 trial cohort (n = 32). The main results are validated using a different p-tau217 immunoassay. These findings suggest that p-tau217 might be more useful than p-tau181 in the diagnostic work up of AD.Cerebrospinal fluid (CSF) p-tau181 (tau phosphorylated at threonine 181) is an established biomarker of Alzheimer's disease (AD), reflecting abnormal tau metabolism in the brain. Here we investigate the performance of CSF p-tau217 as a biomarker of AD in comparison to p-tau181. In the Swedish BioFINDER cohort (n = 194), p-tau217 shows stronger correlations with the tau positron emission tomography (PET) tracer [18F]flortaucipir, and more accurately identifies individuals with abnormally increased [18F]flortaucipir retention. Furthermore, longitudinal increases in p-tau217 are higher compared to p-tau181 and better correlate with [18F]flortaucipir uptake. P-tau217 correlates better than p-tau181 with CSF and PET measures of neocortical amyloid-β burden and more accurately distinguishes AD dementia from non-AD neurodegenerative disorders. Higher correlations between p-tau217 and [18F]flortaucipir are corroborated in an independent EXPEDITION3 trial cohort (n = 32). The main results are validated using a different p-tau217 immunoassay. These findings suggest that p-tau217 might be more useful than p-tau181 in the diagnostic work up of AD. Cerebrospinal fluid (CSF) p-tau181 (tau phosphorylated at threonine 181) is an established biomarker of Alzheimer’s disease (AD), reflecting abnormal tau metabolism in the brain. Here we investigate the performance of CSF p-tau217 as a biomarker of AD in comparison to p-tau181. In the Swedish BioFINDER cohort ( n = 194), p-tau217 shows stronger correlations with the tau positron emission tomography (PET) tracer [ 18 F]flortaucipir, and more accurately identifies individuals with abnormally increased [ 18 F]flortaucipir retention. Furthermore, longitudinal increases in p-tau217 are higher compared to p-tau181 and better correlate with [ 18 F]flortaucipir uptake. P-tau217 correlates better than p-tau181 with CSF and PET measures of neocortical amyloid-β burden and more accurately distinguishes AD dementia from non-AD neurodegenerative disorders. Higher correlations between p-tau217 and [ 18 F]flortaucipir are corroborated in an independent EXPEDITION3 trial cohort ( n = 32). The main results are validated using a different p-tau217 immunoassay. These findings suggest that p-tau217 might be more useful than p-tau181 in the diagnostic work up of AD. |
| ArticleNumber | 1683 |
| Author | Janelidze, Shorena Sims, John R. Kolb, Hartmuth Slemmon, Randy Shcherbinin, Sergey Airey, David C. Theunis, Clara Mattsson, Niklas Smith, Ruben Palmqvist, Sebastian Dage, Jeffrey L. Triana-Baltzer, Gallen Hansson, Oskar Stomrud, Erik Chai, Xiyun Proctor, Nicholas K. Mercken, Marc |
| Author_xml | – sequence: 1 givenname: Shorena surname: Janelidze fullname: Janelidze, Shorena email: shorena.janelidze@med.lu.se organization: Clinical Memory Research Unit, Lund University – sequence: 2 givenname: Erik surname: Stomrud fullname: Stomrud, Erik organization: Clinical Memory Research Unit, Lund University – sequence: 3 givenname: Ruben orcidid: 0000-0001-7147-0112 surname: Smith fullname: Smith, Ruben organization: Clinical Memory Research Unit, Lund University, Department of Neurology, Skåne University Hospital – sequence: 4 givenname: Sebastian surname: Palmqvist fullname: Palmqvist, Sebastian organization: Clinical Memory Research Unit, Lund University, Department of Neurology, Skåne University Hospital – sequence: 5 givenname: Niklas orcidid: 0000-0002-8885-7724 surname: Mattsson fullname: Mattsson, Niklas organization: Clinical Memory Research Unit, Lund University, Department of Neurology, Skåne University Hospital, Wallenberg Center for Molecular Medicine, Lund University – sequence: 6 givenname: David C. surname: Airey fullname: Airey, David C. organization: Eli Lilly and Company – sequence: 7 givenname: Nicholas K. orcidid: 0000-0003-1525-3580 surname: Proctor fullname: Proctor, Nicholas K. organization: Eli Lilly and Company – sequence: 8 givenname: Xiyun surname: Chai fullname: Chai, Xiyun organization: Eli Lilly and Company – sequence: 9 givenname: Sergey surname: Shcherbinin fullname: Shcherbinin, Sergey organization: Eli Lilly and Company – sequence: 10 givenname: John R. surname: Sims fullname: Sims, John R. organization: Eli Lilly and Company – sequence: 11 givenname: Gallen surname: Triana-Baltzer fullname: Triana-Baltzer, Gallen organization: Neuroscience Biomarkers, Janssen Research & Development – sequence: 12 givenname: Clara surname: Theunis fullname: Theunis, Clara organization: Janssen Pharmaceutical Companies of Johnson & Johnson – sequence: 13 givenname: Randy surname: Slemmon fullname: Slemmon, Randy organization: Neuroscience Biomarkers, Janssen Research & Development – sequence: 14 givenname: Marc surname: Mercken fullname: Mercken, Marc organization: Janssen Pharmaceutical Companies of Johnson & Johnson – sequence: 15 givenname: Hartmuth surname: Kolb fullname: Kolb, Hartmuth email: HKolb1@ITS.jnj.com organization: Neuroscience Biomarkers, Janssen Research & Development – sequence: 16 givenname: Jeffrey L. orcidid: 0000-0002-2192-1699 surname: Dage fullname: Dage, Jeffrey L. email: Jeffrey.Dage@Lilly.com organization: Eli Lilly and Company – sequence: 17 givenname: Oskar orcidid: 0000-0001-8467-7286 surname: Hansson fullname: Hansson, Oskar email: Oskar.Hansson@med.lu.se organization: Clinical Memory Research Unit, Lund University, Memory Clinic, Skåne University Hospital |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32246036$$D View this record in MEDLINE/PubMed https://lup.lub.lu.se/record/0ab1fa92-d2ad-482f-aaaf-a7b2dc0add12$$DView record from Swedish Publication Index oai:portal.research.lu.se:publications/0ab1fa92-d2ad-482f-aaaf-a7b2dc0add12$$DView record from Swedish Publication Index |
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| CorporateAuthor | MultiPark: Multidisciplinary research focused on Parkinson's disease Lunds universitet Profile areas and other strong research environments Department of Clinical Sciences, Malmö Lund University Strategiska forskningsområden (SFO) Faculty of Medicine Strategic research areas (SRA) Clinical Memory Research Klinisk minnesforskning Medicinska fakulteten Profilområden och andra starka forskningsmiljöer Institutionen för kliniska vetenskaper, Malmö |
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| Snippet | Cerebrospinal fluid (CSF) p-tau181 (tau phosphorylated at threonine 181) is an established biomarker of Alzheimer’s disease (AD), reflecting abnormal tau... Cerebrospinal fluid (CSF) p-tau181 (tau phosphorylated at threonine 181) is an established biomarker of Alzheimer's disease (AD), reflecting abnormal tau... Cerebrospinal fluid (CSF) p-tau181 (tau phosphorylated at threonine 181) is an established biomarker of Alzheimer’s disease (AD) reflecting abnormal tau... |
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| SubjectTerms | 692/53/2421 692/617/375/132/1283 Aged Aged, 80 and over Alzheimer Disease - cerebrospinal fluid Alzheimer Disease - diagnosis Alzheimer's disease Basic Medicine Biomarkers Biomarkers - cerebrospinal fluid Brain Brain - diagnostic imaging Carbolines - administration & dosage Cerebrospinal fluid Contrast Media - administration & dosage Dementia disorders Diagnosis, Differential Diagnostic systems Feasibility Studies Female Fluorine isotopes Humanities and Social Sciences Humans Immunoassay Male Medical and Health Sciences Medicin och hälsovetenskap Medicinska och farmaceutiska grundvetenskaper Metabolism Middle Aged multidisciplinary Neocortex Neurodegenerative diseases Neurosciences Neurovetenskaper Phosphorylation Positron emission Positron emission tomography Science Science (multidisciplinary) Sweden Tau protein tau Proteins - cerebrospinal fluid tau Proteins - metabolism Threonine Tomography |
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| Title | Cerebrospinal fluid p-tau217 performs better than p-tau181 as a biomarker of Alzheimer’s disease |
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