Altered hypoxia-induced cellular responses and inflammatory profile in lung fibroblasts from COPD patients compared to control subjects

• Published in: Respiratory research Vol. 25; no. 1; pp. 282 - 14
• Main Authors: Martin, Ryde, Nora, Marek, Anna, Löfdahl, Olivia, Pekny, Leif, Bjermer, Gunilla, Westergren-Thorsson, Ellen, Tufvesson, Anna-Karin, Larsson-Callerfelt
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 16.07.2024; BioMed Central; BMC
• Subjects: Aged; Analysis; Bronchitis; Case-Control Studies; Cell Hypoxia - physiology; Cells, Cultured; Clinical Medicine; Comparative analysis; Complications and side effects; COPD; Development and progression; Diagnosis; Endoplasmic Reticulum Stress - physiology; Enzyme-linked immunosorbent assay; ER stress; Female; Fibroblasts; Fibroblasts - metabolism; Fibroblasts - pathology; Gene expression; Genes; Genetic aspects; Health aspects; Humans; Hypoxia; Hypoxia - metabolism; Inflammation; Inflammation - metabolism; Inflammation - pathology; Inflammation Mediators - metabolism; Klinisk medicin; Lung - metabolism; Lung - pathology; Lung diseases, Obstructive; Lung fibroblasts; Lungmedicin och allergi; Male; Medical and Health Sciences; Medicin och hälsovetenskap; Middle Aged; Oxidative stress; Oxidative Stress - physiology; Pulmonary Disease, Chronic Obstructive - genetics; Pulmonary Disease, Chronic Obstructive - metabolism; Pulmonary Disease, Chronic Obstructive - pathology; Remodelling; Respiratory Medicine and Allergy; Risk factors; Scientific equipment and supplies industry; Transforming Growth Factor beta1 - metabolism; Transforming growth factors; Vascular endothelial growth factor; Sweden; United States; Germany; Oxidative stress; Remodelling; ER stress; Hypoxia; Inflammation; Lung fibroblasts; Gene expression; COPD

Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease characterized by chronic bronchitis, emphysema and vascular remodelling. The disease is associated with hypoxia, inflammation and oxidative stress. Lung fibroblasts are important cells in remodelling processes in COPD, as main p...