High Levels of N-Palmitoylethanolamide and N-Stearoylethanolamide in Microdialysate Samples from Myalgic Trapezius Muscle in Women

• Published in: PloS one Vol. 6; no. 11; p. e27257
• Main Authors: Ghafouri, Nazdar, Ghafouri, Bijar, Larsson, Britt, Turkina, Maria V., Karlsson, Linn, Fowler, Christopher J., Gerdle, Björn
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 18.11.2011; Public Library of Science (PLoS)
• Subjects: 2-Arachidonoylglycerol; Adult; Age; Amides; Analgesics; Anandamide; Biology; Body mass index; Burns; Cannabinoids; Chemistry; Chromatography; Chromatography, Liquid - methods; Chronic Pain - etiology; Chronic Pain - metabolism; Comparative analysis; Control methods; Councils; Dialysis Solutions - chemistry; Endocannabinoids; Environmental health; Ethanolamines; Fatty acids; Female; Fibromyalgia; Health sciences; Humans; Inflammation; Liquid chromatography; Mass spectrometry; Mass spectroscopy; MEDICIN; MEDICINE; Metabolism; Microdialysis; Middle Aged; Muscle pain; Muscle, Skeletal - metabolism; Muscle, Skeletal - pathology; Muscular Diseases - complications; Muscular Diseases - metabolism; Myalgia; Nanotechnology - methods; Neck; Neck Pain - etiology; Neck Pain - metabolism; Neurosciences; Pain; Pain management; Pain perception; Palmitic Acids - analysis; Palmitic Acids - metabolism; Palmitoylethanolamide; Rehabilitation; Shoulder; Shoulder Pain - etiology; Shoulder Pain - metabolism; Skeletal muscle; Spectroscopy; Stearic Acids - analysis; Stearic Acids - metabolism; Studies; Tandem Mass Spectrometry - methods; Trapezius muscle; Women; Women's health; Womens health; Sweden; pain; quantification; whiplash-associated disorders; trpv1; fibromyalgia; work; activated-receptor-alpha; acylethanolamine; hyperalgesia; fatty-acid amide

N-acylethanolamines (NAEs) are endogenous compounds that regulate inflammation and pain. These include the cannabinoid ligand anandamide (AEA) and the peroxisome proliferator-activated receptor-α ligand palmitoylethanolamide (PEA). Little is known as to the levels of NAEs in pain states in human, pa...