Activating Transcription Factor 6 Is Necessary and Sufficient for Alcoholic Fatty Liver Disease in Zebrafish

• Published in: PLoS genetics Vol. 10; no. 5; p. e1004335
• Main Authors: Howarth, Deanna L., Lindtner, Claudia, Vacaru, Ana M., Sachidanandam, Ravi, Tsedensodnom, Orkhontuya, Vasilkova, Taisa, Buettner, Christoph, Sadler, Kirsten C.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.05.2014; Public Library of Science (PLoS)
• Subjects: Activating Transcription Factor 6 - genetics; Activating Transcription Factor 6 - metabolism; Activating Transcription Factor 6 - toxicity; Alcoholism; Animals; Animals, Genetically Modified; Biology and Life Sciences; Carcinoma, Hepatocellular - genetics; Carcinoma, Hepatocellular - pathology; Disease Models, Animal; Enzymes; Ethanol; Ethanol - toxicity; Fatty acids; Fatty liver; Fatty Liver, Alcoholic - etiology; Fatty Liver, Alcoholic - genetics; Fatty Liver, Alcoholic - metabolism; Genetic aspects; Health aspects; Hepatocytes - metabolism; Hepatocytes - pathology; Humans; Library collections; Lipid Metabolism - genetics; Lipids; Liver - metabolism; Liver - pathology; Liver cirrhosis; Liver diseases; Liver Neoplasms - genetics; Liver Neoplasms - pathology; Medicine and Health Sciences; Metabolic disorders; Metabolism; Physiological aspects; Protein folding; Protein research; Proteins; Research and Analysis Methods; Rodents; Transcription factors; Transcriptional Activation - genetics; Zebra fish; Zebrafish; Zoological research

Fatty liver disease (FLD) is characterized by lipid accumulation in hepatocytes and is accompanied by secretory pathway dysfunction, resulting in induction of the unfolded protein response (UPR). Activating transcription factor 6 (ATF6), one of three main UPR sensors, functions to both promote FLD d...