DNA Methylation Landscapes of Human Fetal Development

• Published in: PLoS genetics Vol. 11; no. 10; p. e1005583
• Main Authors: Slieker, Roderick C., Roost, Matthias S., van Iperen, Liesbeth, Suchiman, H. Eka D., Tobi, Elmar W., Carlotti, Françoise, de Koning, Eelco J. P., Slagboom, P. Eline, Heijmans, Bastiaan T., Chuva de Sousa Lopes, Susana M.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.10.2015; Public Library of Science (PLoS)
• Subjects: Adrenal Glands - growth & development; Adrenal Glands - metabolism; Amnion - growth & development; Amnion - metabolism; Binding sites; Brain research; Cell Differentiation - genetics; CpG Islands - genetics; Deoxyribonucleic acid; DNA; DNA methylation; DNA Methylation - genetics; Epigenesis, Genetic; Epigenetic inheritance; Epigenetics; Female; Fetal Development - genetics; Gene expression; Gene Expression Regulation, Developmental; Genetic aspects; Genome, Human; Genomes; Humans; Mammals; Methylation; Muscle, Skeletal - growth & development; Muscle, Skeletal - metabolism; Mutation; Organ Specificity - genetics; Pancreas - growth & development; Pancreas - metabolism; Physiological aspects; Pregnancy; Pregnancy Trimester, First - genetics; Pregnancy Trimester, Second - genetics; Promoter Regions, Genetic; Regulatory Sequences, Nucleic Acid; Signatures; Single nucleotide polymorphisms; Stem cells; Studies

Remodelling the methylome is a hallmark of mammalian development and cell differentiation. However, current knowledge of DNA methylation dynamics in human tissue specification and organ development largely stems from the extrapolation of studies in vitro and animal models. Here, we report on the DNA...