Meiotic Crossover Control by Concerted Action of Rad51-Dmc1 in Homolog Template Bias and Robust Homeostatic Regulation

• Published in: PLoS genetics Vol. 9; no. 12; p. e1003978
• Main Authors: Lao, Jessica P., Cloud, Veronica, Huang, Chu-Chun, Grubb, Jennifer, Thacker, Drew, Lee, Chih-Ying, Dresser, Michael E., Hunter, Neil, Bishop, Douglas K.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.12.2013; Public Library of Science (PLoS)
• Subjects: Cell Cycle Proteins - genetics; Cell Cycle Proteins - metabolism; Cell division; Chromatids - genetics; Chromosome Pairing - genetics; Chromosome Segregation - genetics; Chromosomes; Crossing Over, Genetic; Deoxyribonucleic acid; DNA; DNA Breaks, Double-Stranded; DNA repair; DNA Repair - genetics; DNA-Binding Proteins - genetics; DNA-Binding Proteins - metabolism; Genetic recombination; Genetic research; Homeostasis; Homologous Recombination - genetics; Homology (Biology); Meiosis; Meiosis - genetics; Microscopy; Proteins; Rad51 Recombinase - genetics; Rad51 Recombinase - metabolism; Ratios; Regulation; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins - genetics; Saccharomyces cerevisiae Proteins - metabolism; Synaptonemal Complex - genetics; United States

During meiosis, repair of programmed DNA double-strand breaks (DSBs) by recombination promotes pairing of homologous chromosomes and their connection by crossovers. Two DNA strand-exchange proteins, Rad51 and Dmc1, are required for meiotic recombination in many organisms. Studies in budding yeast im...