Transposable Elements Are Major Contributors to the Origin, Diversification, and Regulation of Vertebrate Long Noncoding RNAs

• Published in: PLoS genetics Vol. 9; no. 4; p. e1003470
• Main Authors: Kapusta, Aurélie, Kronenberg, Zev, Lynch, Vincent J., Zhuo, Xiaoyu, Ramsay, LeeAnn, Bourque, Guillaume, Yandell, Mark, Feschotte, Cédric
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.04.2013; Public Library of Science (PLoS)
• Subjects: Animals; Biology; DNA Transposable Elements; Exons; Genetic regulation; Genetic transcription; Genetics; Genomics; Health aspects; Humans; Introns; Medical research; Physiological aspects; Proteins; RNA; RNA, Long Noncoding - genetics; Vertebrates - genetics; United States

Advances in vertebrate genomics have uncovered thousands of loci encoding long noncoding RNAs (lncRNAs). While progress has been made in elucidating the regulatory functions of lncRNAs, little is known about their origins and evolution. Here we explore the contribution of transposable elements (TEs)...