Anaplastic Lymphoma Kinase Acts in the Drosophila Mushroom Body to Negatively Regulate Sleep

• Published in: PLoS genetics Vol. 11; no. 11; p. e1005611
• Main Authors: Bai, Lei, Sehgal, Amita
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.11.2015; Public Library of Science (PLoS)
• Subjects: Analysis; Anaplastic Lymphoma Kinase; Animals; Associative learning; Care and treatment; Circadian rhythm; Complications and side effects; Drosophila; Drosophila - physiology; Genes; Genotype & phenotype; Insects; Kinases; Lymphomas; Medical research; Memory; Mushroom Bodies - enzymology; Physiological aspects; Receptor Protein-Tyrosine Kinases - genetics; Receptor Protein-Tyrosine Kinases - metabolism; Sleep; Sleep - physiology

Though evidence is mounting that a major function of sleep is to maintain brain plasticity and consolidate memory, little is known about the molecular pathways by which learning and sleep processes intercept. Anaplastic lymphoma kinase (Alk), the gene encoding a tyrosine receptor kinase whose inadve...