Anaplastic Lymphoma Kinase Acts in the Drosophila Mushroom Body to Negatively Regulate Sleep
Though evidence is mounting that a major function of sleep is to maintain brain plasticity and consolidate memory, little is known about the molecular pathways by which learning and sleep processes intercept. Anaplastic lymphoma kinase (Alk), the gene encoding a tyrosine receptor kinase whose inadve...
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| Published in | PLoS genetics Vol. 11; no. 11; p. e1005611 |
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| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Public Library of Science
01.11.2015
Public Library of Science (PLoS) |
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| Abstract | Though evidence is mounting that a major function of sleep is to maintain brain plasticity and consolidate memory, little is known about the molecular pathways by which learning and sleep processes intercept. Anaplastic lymphoma kinase (Alk), the gene encoding a tyrosine receptor kinase whose inadvertent activation is the cause of many cancers, is implicated in synapse formation and cognitive functions. In particular, Alk genetically interacts with Neurofibromatosis 1 (Nf1) to regulate growth and associative learning in flies. We show that Alk mutants have increased sleep. Using a targeted RNAi screen we localized the negative effects of Alk on sleep to the mushroom body, a structure important for both sleep and memory. We also report that mutations in Nf1 produce a sexually dimorphic short sleep phenotype, and suppress the long sleep phenotype of Alk. Thus Alk and Nf1 interact in both learning and sleep regulation, highlighting a common pathway in these two processes. |
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| AbstractList |
Though evidence is mounting that a major function of sleep is to maintain brain plasticity and consolidate memory, little is known about the molecular pathways by which learning and sleep processes intercept. Anaplastic lymphoma kinase (Alk), the gene encoding a tyrosine receptor kinase whose inadvertent activation is the cause of many cancers, is implicated in synapse formation and cognitive functions. In particular, Alk genetically interacts with Neurofibromatosis 1 (Nf1) to regulate growth and associative learning in flies. We show that Alk mutants have increased sleep. Using a targeted RNAi screen we localized the negative effects of Alk on sleep to the mushroom body, a structure important for both sleep and memory. We also report that mutations in Nf1 produce a sexually dimorphic short sleep phenotype, and suppress the long sleep phenotype of Alk. Thus Alk and Nf1 interact in both learning and sleep regulation, highlighting a common pathway in these two processes. Though evidence is mounting that a major function of sleep is to maintain brain plasticity and consolidate memory, little is known about the molecular pathways by which learning and sleep processes intercept. Anaplastic lymphoma kinase (Alk), the gene encoding a tyrosine receptor kinase whose inadvertent activation is the cause of many cancers, is implicated in synapse formation and cognitive functions. In particular, Alk genetically interacts with Neurofibromatosis 1 (Nf1) to regulate growth and associative learning in flies. We show that Alk mutants have increased sleep. Using a targeted RNAi screen we localized the negative effects of Alk on sleep to the mushroom body, a structure important for both sleep and memory. We also report that mutations in Nf1 produce a sexually dimorphic short sleep phenotype, and suppress the long sleep phenotype of Alk. Thus Alk and Nf1 interact in both learning and sleep regulation, highlighting a common pathway in these two processes. Though evidence is mounting that a major function of sleep is to maintain brain plasticity and consolidate memory, little is known about the molecular pathways by which learning and sleep processes intercept. Anaplastic lymphoma kinase ( Alk ), the gene encoding a tyrosine receptor kinase whose inadvertent activation is the cause of many cancers, is implicated in synapse formation and cognitive functions. In particular, Alk genetically interacts with Neurofibromatosis 1 ( Nf1 ) to regulate growth and associative learning in flies. We show that Alk mutants have increased sleep. Using a targeted RNAi screen we localized the negative effects of Alk on sleep to the mushroom body, a structure important for both sleep and memory. We also report that mutations in Nf1 produce a sexually dimorphic short sleep phenotype, and suppress the long sleep phenotype of Alk . Thus Alk and Nf1 interact in both learning and sleep regulation, highlighting a common pathway in these two processes. Animal and human studies suggest that sleep has a profound impact on learning and memory. However, little is known about the molecular pathways linking these phenomena. We report that mutations in the Drosophila Anaplastic lymphoma kinase ( Alk ) gene, an ortholog of a human oncogene ALK, cause increased sleep. ALK is required for sleep suppression in the mushroom body, a structure important for both sleep and memory. ALK generally activates the Ras/ERK pathway, which is negatively regulated by Neurofibromin 1 (NF1). Mutations in Nf1 are the causes of the common neurological disorder Neurofibromatosis type 1 (NF1), which affects 1 in 3,000 live births. We find that male flies lacking the NF1 protein have reduced sleep, a phenotype opposite that of Alk flies. Interestingly, even though mutations in Nf1 don’t always cause short sleep in female flies, they suppress the sleep increase induced by ALK inactivation. Previous studies have shown that Alk and Nf1 play antagonistic roles in learning and that both genes regulate synaptic growth. Thus Alk and Nf1 interact to regulate both sleep and learning, suggesting that the two processes share a common pathway. Our results support a model in which changes in synaptic plasticity during sleep promote learning and memory. Though evidence is mounting that a major function of sleep is to maintain brain plasticity and consolidate memory, little is known about the molecular pathways by which learning and sleep processes intercept. Anaplastic lymphoma kinase (Alk), the gene encoding a tyrosine receptor kinase whose inadvertent activation is the cause of many cancers, is implicated in synapse formation and cognitive functions. In particular, Alk genetically interacts with Neurofibromatosis 1 (Nf1) to regulate growth and associative learning in flies. We show that Alk mutants have increased sleep. Using a targeted RNAi screen we localized the negative effects of Alk on sleep to the mushroom body, a structure important for both sleep and memory. We also report that mutations in Nf1 produce a sexually dimorphic short sleep phenotype, and suppress the long sleep phenotype of Alk. Thus Alk and Nf1 interact in both learning and sleep regulation, highlighting a common pathway in these two processes.Though evidence is mounting that a major function of sleep is to maintain brain plasticity and consolidate memory, little is known about the molecular pathways by which learning and sleep processes intercept. Anaplastic lymphoma kinase (Alk), the gene encoding a tyrosine receptor kinase whose inadvertent activation is the cause of many cancers, is implicated in synapse formation and cognitive functions. In particular, Alk genetically interacts with Neurofibromatosis 1 (Nf1) to regulate growth and associative learning in flies. We show that Alk mutants have increased sleep. Using a targeted RNAi screen we localized the negative effects of Alk on sleep to the mushroom body, a structure important for both sleep and memory. We also report that mutations in Nf1 produce a sexually dimorphic short sleep phenotype, and suppress the long sleep phenotype of Alk. Thus Alk and Nf1 interact in both learning and sleep regulation, highlighting a common pathway in these two processes. |
| Audience | Academic |
| Author | Bai, Lei Sehgal, Amita |
| AuthorAffiliation | 2 Department of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America Washington University Medical School, UNITED STATES 1 Howard Hughes Medical Institute, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America |
| AuthorAffiliation_xml | – name: Washington University Medical School, UNITED STATES – name: 2 Department of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America – name: 1 Howard Hughes Medical Institute, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/26536237$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1093/sleep/32.11.1417 10.1126/science.1202249 10.1016/j.neuron.2008.10.042 10.1016/j.cub.2008.07.028 10.1002/ana.24093 10.1038/sj.npp.1301446 10.1016/j.cub.2005.05.025 10.1002/dneu.22056 10.1002/1096-9861(20010319)431:4<481::AID-CNE1084>3.0.CO;2-7 10.1016/j.cell.2014.02.024 10.1038/nmeth.1561 10.1126/science.276.5313.791 10.1126/science.1250553 10.1177/0883073813500849 10.1242/dev.047878 10.1016/j.cell.2011.06.040 10.1016/S0896-6273(00)80877-6 10.1002/ajmg.a.35915 10.1126/science.1202839 10.1242/dev.118.2.401 10.1126/science.1063097 10.1038/srep08454 10.5665/sleep.1744 10.1038/nature01950 10.1016/j.neuron.2008.10.048 10.1523/JNEUROSCI.2048-05.2005 10.1016/j.neuron.2010.01.032 10.1371/journal.pone.0022636 10.1371/journal.pgen.1003958 10.1016/j.neuron.2013.12.025 10.1016/j.neuron.2006.11.021 10.1016/j.pbb.2011.10.024 10.1523/JNEUROSCI.4691-10.2011 10.1371/journal.pone.0081554 10.1016/j.cell.2007.02.024 10.1038/sj.onc.1200849 10.1038/sj.embor.embor897 10.1016/j.cub.2008.08.033 10.1523/JNEUROSCI.3415-11.2011 10.1126/science.1089035 10.1046/j.1365-2443.2001.00440.x 10.1038/35002593 10.1016/j.tins.2011.07.005 10.1523/JNEUROSCI.1756-12.2012 10.1093/sleep/31.11.1587 10.1126/science.1166673 10.1371/journal.pgen.1002281 10.1080/01677060802471718 10.1016/S1567-133X(01)00011-4 10.1523/JNEUROSCI.5761-10.2011 10.1523/JNEUROSCI.0283-10.2010 10.1042/BJ20090387 10.1038/nn1957 10.1038/nature04739 10.1038/nature04811 10.1016/B978-0-12-387003-2.00009-4 10.1523/JNEUROSCI.4830-08.2009 10.1016/j.celrep.2012.09.011 10.1038/nature01916 10.1126/science.1063530 10.1534/genetics.104.026658 10.1016/B978-0-444-52006-7.00007-1 10.1186/1471-2164-14-281 10.1126/science.1166657 10.1038/nn2035 |
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| Copyright | COPYRIGHT 2015 Public Library of Science 2015 Bai, Sehgal 2015 Bai, Sehgal 2015 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Mushroom Body to Negatively Regulate Sleep. PLoS Genet 11(11): e1005611. doi:10.1371/journal.pgen.1005611 |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Conceived and designed the experiments: LB AS. Performed the experiments: LB. Analyzed the data: LB. Wrote the paper: LB AS. The authors have declared that no competing interests exist. |
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| References | X Li (ref9) 2009; 32 RH Palmer (ref11) 2009; 420 R Andretic (ref31) 2005; 15 J Rohrbough (ref19) 2013; 73 R Stickgold (ref6) 2001; 294 D Bushey (ref55) 2011; 332 K Foltenyi (ref36) 2007; 10 A Crocker (ref37) 2010; 65 V Sheeba (ref39) 2008; 18 GD Leschziner (ref45) 2013; 161A SE McGuire (ref40) 2003; 302 Y Aso (ref42) 2009; 23 T Siegmund (ref65) 2001; 431 JA Williams (ref22) 2001; 293 GF Gilestro (ref5) 2009; 324 DM Gohl (ref63) 2011; 8 C Englund (ref16) 2003; 425 JG Bilsland (ref20) 2008; 33 AK Licis (ref44) 2013; 28 D Bushey (ref10) 2011; 99 DJ Cavanaugh (ref60) 2014; 157 JE Zimmerman (ref24) 2012; 35 T Iwahara (ref12) 1997; 14 ST Harbison (ref53) 2013; 14 HH Lee (ref15) 2003; 425 G Tononi (ref3) 2014; 81 JE Zimmerman (ref27) 2008; 31 AH Brand (ref62) 1993; 118 I The (ref46) 1997; 276 CE Loren (ref23) 2003; 4 WM Vanderheyden (ref51) 2013; 8 ME Buchanan (ref52) 2010; 30 E Bazigou (ref17) 2007; 128 KA Diggs-Andrews (ref54) 2014; 75 AW Lasek (ref49) 2011; 31 K Kume (ref32) 2005; 25 A Jenett (ref43) 2012; 2 JY Gouzi (ref14) 2011; 7 LY Cheng (ref18) 2011; 146 KM Parisky (ref38) 2008; 60 C Florian (ref7) 2011; 31 CE Loren (ref13) 2001; 6 JB Weiss (ref21) 2012; 100 E Ryder (ref25) 2004; 167 JM Donlea (ref35) 2011; 332 P.M. Salvaterra (ref64) 2001; 1 D Bushey (ref56) 2009; 29 L Seugnet (ref8) 2008; 18 G Wang (ref2) 2011; 34 KM Hartse (ref1) 2011; 98 KH Low (ref26) 2008; 60 PI Tsai (ref58) 2012; 32 JA Walker (ref59) 2013; 9 MS Kayser (ref66) 2014; 344 J Rohrbough (ref57) 2010; 137 MC Barone (ref29) 2013 JL Pitman (ref34) 2006; 441 R Faville (ref28) 2015; 5 MJ Krashes (ref41) 2007; 53 JM Donlea (ref61) 2009; 324 JC Hendricks (ref30) 2000; 25 VV Vyazovskiy (ref4) 2008; 11 HF Guo (ref47) 2000; 403 WJ Joiner (ref33) 2006; 441 Y Shinkai (ref48) 2011; 31 AW Lasek (ref50) 2011; 6 |
| References_xml | – volume: 32 start-page: 1417 year: 2009 ident: ref9 article-title: Sleep deprivation specifically impairs short-term olfactory memory in Drosophila publication-title: Sleep doi: 10.1093/sleep/32.11.1417 – volume: 332 start-page: 1571 year: 2011 ident: ref35 article-title: Inducing sleep by remote control facilitates memory consolidation in Drosophila publication-title: Science doi: 10.1126/science.1202249 – volume: 60 start-page: 672 year: 2008 ident: ref38 article-title: PDF cells are a GABA-responsive wake-promoting component of the Drosophila sleep circuit publication-title: Neuron doi: 10.1016/j.neuron.2008.10.042 – volume: 18 start-page: 1110 year: 2008 ident: ref8 article-title: D1 receptor activation in the mushroom bodies rescues sleep-loss-induced learning impairments in Drosophila publication-title: Curr Biol doi: 10.1016/j.cub.2008.07.028 – volume: 75 start-page: 309 year: 2014 ident: ref54 article-title: Sex Is a major determinant of neuronal dysfunction in neurofibromatosis type 1 publication-title: Ann Neurol doi: 10.1002/ana.24093 – volume: 33 start-page: 685 year: 2008 ident: ref20 article-title: Behavioral and neurochemical alterations in mice deficient in anaplastic lymphoma kinase suggest therapeutic potential for psychiatric indications publication-title: Neuropsychopharmacology doi: 10.1038/sj.npp.1301446 – volume: 15 start-page: 1165 year: 2005 ident: ref31 article-title: Dopaminergic modulation of arousal in Drosophila publication-title: Curr Biol doi: 10.1016/j.cub.2005.05.025 – volume: 73 start-page: 189 year: 2013 ident: ref19 article-title: Jelly Belly trans-synaptic signaling to anaplastic lymphoma kinase regulates neurotransmission strength and synapse architecture publication-title: Dev Neurobiol doi: 10.1002/dneu.22056 – volume: 431 start-page: 481 year: 2001 ident: ref65 article-title: Innervation of the ring gland of Drosophila melanogaster publication-title: J Comp Neurol doi: 10.1002/1096-9861(20010319)431:4<481::AID-CNE1084>3.0.CO;2-7 – volume: 157 start-page: 689 year: 2014 ident: ref60 article-title: Identification of a circadian output circuit for rest:activity rhythms in Drosophila publication-title: Cell doi: 10.1016/j.cell.2014.02.024 – volume: 8 start-page: 231 year: 2011 ident: ref63 article-title: A versatile in vivo system for directed dissection of gene expression patterns publication-title: Nat Methods doi: 10.1038/nmeth.1561 – volume: 276 start-page: 791 year: 1997 ident: ref46 article-title: Rescue of a Drosophila NF1 mutant phenotype by protein kinase A publication-title: Science doi: 10.1126/science.276.5313.791 – volume: 344 start-page: 269 year: 2014 ident: ref66 article-title: A critical period of sleep for development of courtship circuitry and behavior in Drosophila publication-title: Science doi: 10.1126/science.1250553 – volume: 28 start-page: 1400 year: 2013 ident: ref44 article-title: Prevalence of Sleep Disturbances in Children With Neurofibromatosis Type 1 publication-title: J Child Neurol doi: 10.1177/0883073813500849 – volume: 137 start-page: 3523 year: 2010 ident: ref57 article-title: Anterograde Jelly belly ligand to Alk receptor signaling at developing synapses is regulated by Mind the gap publication-title: Development doi: 10.1242/dev.047878 – volume: 146 start-page: 435 year: 2011 ident: ref18 article-title: Anaplastic lymphoma kinase spares organ growth during nutrient restriction in Drosophila publication-title: Cell doi: 10.1016/j.cell.2011.06.040 – volume: 25 start-page: 129 year: 2000 ident: ref30 article-title: Rest in Drosophila is a sleep-like state publication-title: Neuron doi: 10.1016/S0896-6273(00)80877-6 – volume: 161A start-page: 1319 year: 2013 ident: ref45 article-title: Sleep disturbance as part of the neurofibromatosis type 1 phenotype in adults publication-title: Am J Med Genet A doi: 10.1002/ajmg.a.35915 – volume: 332 start-page: 1576 year: 2011 ident: ref55 article-title: Sleep and synaptic homeostasis: structural evidence in Drosophila publication-title: Science doi: 10.1126/science.1202839 – volume: 118 start-page: 401 year: 1993 ident: ref62 article-title: Targeted gene expression as a means of altering cell fates and generating dominant phenotypes publication-title: Development doi: 10.1242/dev.118.2.401 – volume: 293 start-page: 2251 year: 2001 ident: ref22 article-title: A circadian output in Drosophila mediated by neurofibromatosis-1 and Ras/MAPK publication-title: Science doi: 10.1126/science.1063097 – volume: 5 start-page: 8454 year: 2015 ident: ref28 article-title: How deeply does your mutant sleep? Probing arousal to better understand sleep defects in Drosophila publication-title: Sci Rep doi: 10.1038/srep08454 – volume: 35 start-page: 545 year: 2012 ident: ref24 article-title: Genetic background has a major impact on differences in sleep resulting from environmental influences in Drosophila publication-title: Sleep doi: 10.5665/sleep.1744 – volume: 425 start-page: 512 year: 2003 ident: ref16 article-title: Jeb signals through the Alk receptor tyrosine kinase to drive visceral muscle fusion publication-title: Nature doi: 10.1038/nature01950 – volume: 60 start-page: 1054 year: 2008 ident: ref26 article-title: Natural variation in the splice site strength of a clock gene and species-specific thermal adaptation publication-title: Neuron doi: 10.1016/j.neuron.2008.10.048 – volume: 25 start-page: 7377 year: 2005 ident: ref32 article-title: Dopamine is a regulator of arousal in the fruit fly publication-title: J Neurosci doi: 10.1523/JNEUROSCI.2048-05.2005 – volume: 65 start-page: 670 year: 2010 ident: ref37 article-title: Identification of a neural circuit that underlies the effects of octopamine on sleep:wake behavior publication-title: Neuron doi: 10.1016/j.neuron.2010.01.032 – volume: 6 start-page: e22636 year: 2011 ident: ref50 article-title: An evolutionary conserved role for anaplastic lymphoma kinase in behavioral responses to ethanol publication-title: PLoS One doi: 10.1371/journal.pone.0022636 – volume: 9 start-page: e1003958 year: 2013 ident: ref59 article-title: Genetic and functional studies implicate synaptic overgrowth and ring gland cAMP/PKA signaling defects in the Drosophila melanogaster neurofibromatosis-1 growth deficiency publication-title: PLoS Genet doi: 10.1371/journal.pgen.1003958 – volume: 81 start-page: 12 year: 2014 ident: ref3 article-title: Sleep and the price of plasticity: from synaptic and cellular homeostasis to memory consolidation and integration publication-title: Neuron doi: 10.1016/j.neuron.2013.12.025 – volume: 53 start-page: 103 year: 2007 ident: ref41 article-title: Sequential use of mushroom body neuron subsets during drosophila odor memory processing publication-title: Neuron doi: 10.1016/j.neuron.2006.11.021 – volume: 100 start-page: 566 year: 2012 ident: ref21 article-title: Anaplastic lymphoma kinase and leukocyte tyrosine kinase: functions and genetic interactions in learning, memory and adult neurogenesis publication-title: Pharmacol Biochem Behav doi: 10.1016/j.pbb.2011.10.024 – volume: 31 start-page: 3007 year: 2011 ident: ref48 article-title: Behavioral choice between conflicting alternatives is regulated by a receptor guanylyl cyclase, GCY-28, and a receptor tyrosine kinase, SCD-2, in AIA interneurons of Caenorhabditis elegans publication-title: J Neurosci doi: 10.1523/JNEUROSCI.4691-10.2011 – volume: 8 start-page: e81554 year: 2013 ident: ref51 article-title: ERK phosphorylation regulates sleep and plasticity in Drosophila publication-title: PLoS One doi: 10.1371/journal.pone.0081554 – volume: 128 start-page: 961 year: 2007 ident: ref17 article-title: Anterograde Jelly belly and Alk receptor tyrosine kinase signaling mediates retinal axon targeting in Drosophila publication-title: Cell doi: 10.1016/j.cell.2007.02.024 – volume: 14 start-page: 439 year: 1997 ident: ref12 article-title: Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system publication-title: Oncogene doi: 10.1038/sj.onc.1200849 – volume: 4 start-page: 781 year: 2003 ident: ref23 article-title: A crucial role for the Anaplastic lymphoma kinase receptor tyrosine kinase in gut development in Drosophila melanogaster publication-title: EMBO Rep doi: 10.1038/sj.embor.embor897 – volume: 18 start-page: 1537 year: 2008 ident: ref39 article-title: Large ventral lateral neurons modulate arousal and sleep in Drosophila publication-title: Curr Biol doi: 10.1016/j.cub.2008.08.033 – volume: 31 start-page: 14134 year: 2011 ident: ref49 article-title: Alk is a transcriptional target of LMO4 and ERalpha that promotes cocaine sensitization and reward publication-title: J Neurosci doi: 10.1523/JNEUROSCI.3415-11.2011 – volume: 302 start-page: 1765 year: 2003 ident: ref40 article-title: Spatiotemporal rescue of memory dysfunction in Drosophila publication-title: Science doi: 10.1126/science.1089035 – volume: 6 start-page: 531 year: 2001 ident: ref13 article-title: Identification and characterization of DAlk: a novel Drosophila melanogaster RTK which drives ERK activation in vivo publication-title: Genes Cells doi: 10.1046/j.1365-2443.2001.00440.x – volume: 403 start-page: 895 year: 2000 ident: ref47 article-title: A neurofibromatosis-1-regulated pathway is required for learning in Drosophila publication-title: Nature doi: 10.1038/35002593 – volume: 34 start-page: 452 year: 2011 ident: ref2 article-title: Synaptic plasticity in sleep: learning, homeostasis and disease publication-title: Trends Neurosci doi: 10.1016/j.tins.2011.07.005 – volume: 32 start-page: 16971 year: 2012 ident: ref58 article-title: Neurofibromin mediates FAK signaling in confining synapse growth at Drosophila neuromuscular junctions publication-title: J Neurosci doi: 10.1523/JNEUROSCI.1756-12.2012 – volume: 31 start-page: 1587 year: 2008 ident: ref27 article-title: A video method to study Drosophila sleep publication-title: Sleep doi: 10.1093/sleep/31.11.1587 – volume: 324 start-page: 109 year: 2009 ident: ref5 article-title: Widespread changes in synaptic markers as a function of sleep and wakefulness in Drosophila publication-title: Science doi: 10.1126/science.1166673 – volume: 7 start-page: e1002281 year: 2011 ident: ref14 article-title: The receptor tyrosine kinase Alk controls neurofibromin functions in Drosophila growth and learning publication-title: PLoS Genet doi: 10.1371/journal.pgen.1002281 – volume: 23 start-page: 156 year: 2009 ident: ref42 article-title: The mushroom body of adult Drosophila characterized by GAL4 drivers publication-title: J Neurogenet doi: 10.1080/01677060802471718 – volume: 1 start-page: 73 year: 2001 ident: ref64 article-title: Drosophila cholinergic neurons and processes visualized with Gal4/UAS-GFP. Brain Res publication-title: Gene Expr. Patterns doi: 10.1016/S1567-133X(01)00011-4 – start-page: e50339 year: 2013 ident: ref29 article-title: Assessing neurodegenerative phenotypes in Drosophila dopaminergic neurons by climbing assays and whole brain immunostaining publication-title: J Vis Exp – volume: 31 start-page: 6956 year: 2011 ident: ref7 article-title: Astrocyte-derived adenosine and A1 receptor activity contribute to sleep loss-induced deficits in hippocampal synaptic plasticity and memory in mice publication-title: J Neurosci doi: 10.1523/JNEUROSCI.5761-10.2011 – volume: 30 start-page: 10135 year: 2010 ident: ref52 article-title: A distinct set of Drosophila brain neurons required for neurofibromatosis type 1-dependent learning and memory publication-title: J Neurosci doi: 10.1523/JNEUROSCI.0283-10.2010 – volume: 420 start-page: 345 year: 2009 ident: ref11 article-title: Anaplastic lymphoma kinase: signalling in development and disease publication-title: Biochem J doi: 10.1042/BJ20090387 – volume: 10 start-page: 1160 year: 2007 ident: ref36 article-title: Activation of EGFR and ERK by rhomboid signaling regulates the consolidation and maintenance of sleep in Drosophila publication-title: Nat Neurosci doi: 10.1038/nn1957 – volume: 441 start-page: 753 year: 2006 ident: ref34 article-title: A dynamic role for the mushroom bodies in promoting sleep in Drosophila publication-title: Nature doi: 10.1038/nature04739 – volume: 441 start-page: 757 year: 2006 ident: ref33 article-title: Sleep in Drosophila is regulated by adult mushroom bodies publication-title: Nature doi: 10.1038/nature04811 – volume: 99 start-page: 213 year: 2011 ident: ref10 article-title: From genetics to structure to function: exploring sleep in Drosophila publication-title: Int Rev Neurobiol doi: 10.1016/B978-0-12-387003-2.00009-4 – volume: 29 start-page: 1948 year: 2009 ident: ref56 article-title: The Drosophila fragile X mental retardation gene regulates sleep need publication-title: J Neurosci doi: 10.1523/JNEUROSCI.4830-08.2009 – volume: 2 start-page: 991 year: 2012 ident: ref43 article-title: A GAL4-driver line resource for Drosophila neurobiology publication-title: Cell Rep doi: 10.1016/j.celrep.2012.09.011 – volume: 425 start-page: 507 year: 2003 ident: ref15 article-title: Jelly belly protein activates the receptor tyrosine kinase Alk to specify visceral muscle pioneers publication-title: Nature doi: 10.1038/nature01916 – volume: 294 start-page: 1052 year: 2001 ident: ref6 article-title: Sleep, learning, and dreams: off-line memory reprocessing publication-title: Science doi: 10.1126/science.1063530 – volume: 167 start-page: 797 year: 2004 ident: ref25 article-title: The DrosDel collection: a set of P-element insertions for generating custom chromosomal aberrations in Drosophila melanogaster publication-title: Genetics doi: 10.1534/genetics.104.026658 – volume: 98 start-page: 97 year: 2011 ident: ref1 article-title: The phylogeny of sleep publication-title: Handb Clin Neurol doi: 10.1016/B978-0-444-52006-7.00007-1 – volume: 14 start-page: 281 year: 2013 ident: ref53 article-title: Genome-wide association study of sleep in Drosophila melanogaster publication-title: BMC Genomics doi: 10.1186/1471-2164-14-281 – volume: 324 start-page: 105 year: 2009 ident: ref61 article-title: Use-dependent plasticity in clock neurons regulates sleep need in Drosophila publication-title: Science doi: 10.1126/science.1166657 – volume: 11 start-page: 200 year: 2008 ident: ref4 article-title: Molecular and electrophysiological evidence for net synaptic potentiation in wake and depression in sleep publication-title: Nat Neurosci doi: 10.1038/nn2035 |
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| SubjectTerms | Analysis Anaplastic Lymphoma Kinase Animals Associative learning Care and treatment Circadian rhythm Complications and side effects Drosophila Drosophila - physiology Genes Genotype & phenotype Insects Kinases Lymphomas Medical research Memory Mushroom Bodies - enzymology Physiological aspects Receptor Protein-Tyrosine Kinases - genetics Receptor Protein-Tyrosine Kinases - metabolism Sleep Sleep - physiology |
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| Title | Anaplastic Lymphoma Kinase Acts in the Drosophila Mushroom Body to Negatively Regulate Sleep |
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