Antagonistic Cross-Regulation between Sox9 and Sox10 Controls an Anti-tumorigenic Program in Melanoma

• Published in: PLoS genetics Vol. 11; no. 1; p. e1004877
• Main Authors: Shakhova, Olga, Cheng, Phil, Mishra, Pravin J., Zingg, Daniel, Schaefer, Simon M., Debbache, Julien, Häusel, Jessica, Matter, Claudia, Guo, Theresa, Davis, Sean, Meltzer, Paul, Mihic-Probst, Daniela, Moch, Holger, Wegner, Michael, Merlino, Glenn, Levesque, Mitchell P., Dummer, Reinhard, Santoro, Raffaella, Cinelli, Paolo, Sommer, Lukas
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.01.2015; Public Library of Science (PLoS)
• Subjects: Animals; Apoptosis; Apoptosis - genetics; Carcinogenesis - genetics; Cell Line, Tumor; Colleges & universities; Experiments; Gene expression; Gene Expression Regulation, Neoplastic; Genetic aspects; Hair Follicle; Health aspects; Homeostasis; Humans; Identification and classification; Medical research; Melanocytes - pathology; Melanoma; Melanoma - genetics; Melanoma - pathology; Mice; Proteins; RNA, Small Interfering; Rodents; Skin cancer; Smooth muscle; SOX9 Transcription Factor - biosynthesis; SOX9 Transcription Factor - genetics; SOXE Transcription Factors - biosynthesis; SOXE Transcription Factors - genetics; Stem cells; Transcription factors

Melanoma is the most fatal skin cancer, but the etiology of this devastating disease is still poorly understood. Recently, the transcription factor Sox10 has been shown to promote both melanoma initiation and progression. Reducing SOX10 expression levels in human melanoma cells and in a genetic mela...