Myosin Vb mediated plasma membrane homeostasis regulates peridermal cell size and maintains tissue homeostasis in the zebrafish epidermis

• Published in: PLoS genetics Vol. 10; no. 9; p. e1004614
• Main Authors: Sonal, Sidhaye, Jaydeep, Phatak, Mandar, Banerjee, Shamik, Mulay, Aditya, Deshpande, Ojas, Bhide, Sourabh, Jacob, Tressa, Gehring, Ines, Nuesslein-Volhard, Christiane, Sonawane, Mahendra
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.09.2014; Public Library of Science (PLoS)
• Subjects: Analysis; Animals; Biology and Life Sciences; Cell Count; Cell growth; Cell Membrane - metabolism; Cell membranes; Cell Size; Developmental biology; Embryo, Nonmammalian; Embryos; Endocytosis; Endosomes - metabolism; Epidermis - cytology; Epidermis - embryology; Epidermis - metabolism; Genetic aspects; Genetic Loci; Homeostasis; Lysosomes - metabolism; Models, Biological; Muscle proteins; Mutation; Myosin; Myosin Type V - deficiency; Myosin Type V - genetics; Myosin Type V - metabolism; Phenotype; Physiological aspects; Plasma; Zebra fish; Zebrafish

The epidermis is a stratified epithelium, which forms a barrier to maintain the internal milieu in metazoans. Being the outermost tissue, growth of the epidermis has to be strictly coordinated with the growth of the embryo. The key parameters that determine tissue growth are cell number and cell siz...