Expanding syphilis test uptake using rapid dual self-testing for syphilis and HIV among men who have sex with men in China: A multiarm randomized controlled trial
Low syphilis testing uptake is a major public health issue among men who have sex with men (MSM) in many low- and middle-income countries. Syphilis self-testing (SST) may complement and extend facility-based testing. We aimed to evaluate the effectiveness and costs of providing SST on increasing syp...
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| Published in | PLoS medicine Vol. 19; no. 3; p. e1003930 |
|---|---|
| Main Authors | , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Public Library of Science
02.03.2022
Public Library of Science (PLoS) |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Low syphilis testing uptake is a major public health issue among men who have sex with men (MSM) in many low- and middle-income countries. Syphilis self-testing (SST) may complement and extend facility-based testing. We aimed to evaluate the effectiveness and costs of providing SST on increasing syphilis testing uptake among MSM in China.
An open-label, parallel 3-arm randomized controlled trial (RCT) was conducted between January 7, 2020 and July 17, 2020. Men who were at least 18 years of age, had condomless anal sex with men in the past year, reported not testing for syphilis in the last 6 months, and had a stable residence with mailing addresses were recruited from 124 cities in 26 Chinese provinces. Using block randomization with blocks of size 12, enrolled participants were randomly assigned (1:1:1) into 3 arms: standard of care arm, standard SST arm, and lottery incentivized SST arm (1 in 10 chance to win US$15 if they had a syphilis test). The primary outcome was the proportion of participants who tested for syphilis during the trial period and confirmed with photo verification and between arm comparisons were estimated with risk differences (RDs). Analyses were performed on a modified intention-to-treat basis: Participants were included in the complete case analysis if they had initiated at least 1 follow-up survey. The Syphilis/HIV Duo rapid test kit was used. A total of 451 men were enrolled. In total, 136 (90·7%, 136/150) in the standard of care arm, 142 (94·0%, 142/151) in the standard of SST arm, and 137 (91·3%, 137/150) in the lottery incentivized SST arm were included in the final analysis. The proportion of men who had at least 1 syphilis test during the trial period was 63.4% (95% confidence interval [CI]: 55.5% to 71.3%, p = 0.001) in the standard SST arm, 65.7% (95% CI: 57.7% to 73.6%, p = 0.0002) in the lottery incentivized SST arm, and 14.7% (95% CI: 8.8% to 20.7%, p < 0.001) in the standard of care arm. The estimated RD between the standard SST and standard of care arm was 48.7% (95% CI: 37.8% to 58.4%, p < 0.001). The majority (78.5%, 95% CI: 72.7% to 84.4%, p < 0.001) of syphilis self-testers reported never testing for syphilis. The cost per person tested was US$26.55 for standard SST, US$28.09 for the lottery incentivized SST, and US$66.19 for the standard of care. No study-related adverse events were reported during the study duration. Limitation was that the impact of the Coronavirus Disease 2019 (COVID-19) restrictions may have accentuated demand for decentralized testing.
Compared to standard of care, providing SST significantly increased the proportion of MSM testing for syphilis in China and was cheaper (per person tested).
Chinese Clinical Trial Registry: ChiCTR1900022409. |
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| AbstractList | Low syphilis testing uptake is a major public health issue among men who have sex with men (MSM) in many low- and middle-income countries. Syphilis self-testing (SST) may complement and extend facility-based testing. We aimed to evaluate the effectiveness and costs of providing SST on increasing syphilis testing uptake among MSM in China. An open-label, parallel 3-arm randomized controlled trial (RCT) was conducted between January 7, 2020 and July 17, 2020. Men who were at least 18 years of age, had condomless anal sex with men in the past year, reported not testing for syphilis in the last 6 months, and had a stable residence with mailing addresses were recruited from 124 cities in 26 Chinese provinces. Using block randomization with blocks of size 12, enrolled participants were randomly assigned (1:1:1) into 3 arms: standard of care arm, standard SST arm, and lottery incentivized SST arm (1 in 10 chance to win US$15 if they had a syphilis test). The primary outcome was the proportion of participants who tested for syphilis during the trial period and confirmed with photo verification and between arm comparisons were estimated with risk differences (RDs). Analyses were performed on a modified intention-to-treat basis: Participants were included in the complete case analysis if they had initiated at least 1 follow-up survey. The Syphilis/HIV Duo rapid test kit was used. A total of 451 men were enrolled. In total, 136 (90·7%, 136/150) in the standard of care arm, 142 (94·0%, 142/151) in the standard of SST arm, and 137 (91·3%, 137/150) in the lottery incentivized SST arm were included in the final analysis. The proportion of men who had at least 1 syphilis test during the trial period was 63.4% (95% confidence interval [CI]: 55.5% to 71.3%, p = 0.001) in the standard SST arm, 65.7% (95% CI: 57.7% to 73.6%, p = 0.0002) in the lottery incentivized SST arm, and 14.7% (95% CI: 8.8% to 20.7%, p < 0.001) in the standard of care arm. The estimated RD between the standard SST and standard of care arm was 48.7% (95% CI: 37.8% to 58.4%, p < 0.001). The majority (78.5%, 95% CI: 72.7% to 84.4%, p < 0.001) of syphilis self-testers reported never testing for syphilis. The cost per person tested was US$26.55 for standard SST, US$28.09 for the lottery incentivized SST, and US$66.19 for the standard of care. No study-related adverse events were reported during the study duration. Limitation was that the impact of the Coronavirus Disease 2019 (COVID-19) restrictions may have accentuated demand for decentralized testing. Compared to standard of care, providing SST significantly increased the proportion of MSM testing for syphilis in China and was cheaper (per person tested). BackgroundLow syphilis testing uptake is a major public health issue among men who have sex with men (MSM) in many low- and middle-income countries. Syphilis self-testing (SST) may complement and extend facility-based testing. We aimed to evaluate the effectiveness and costs of providing SST on increasing syphilis testing uptake among MSM in China.Methods and findingsAn open-label, parallel 3-arm randomized controlled trial (RCT) was conducted between January 7, 2020 and July 17, 2020. Men who were at least 18 years of age, had condomless anal sex with men in the past year, reported not testing for syphilis in the last 6 months, and had a stable residence with mailing addresses were recruited from 124 cities in 26 Chinese provinces. Using block randomization with blocks of size 12, enrolled participants were randomly assigned (1:1:1) into 3 arms: standard of care arm, standard SST arm, and lottery incentivized SST arm (1 in 10 chance to win US$15 if they had a syphilis test). The primary outcome was the proportion of participants who tested for syphilis during the trial period and confirmed with photo verification and between arm comparisons were estimated with risk differences (RDs). Analyses were performed on a modified intention-to-treat basis: Participants were included in the complete case analysis if they had initiated at least 1 follow-up survey. The Syphilis/HIV Duo rapid test kit was used. A total of 451 men were enrolled. In total, 136 (90·7%, 136/150) in the standard of care arm, 142 (94·0%, 142/151) in the standard of SST arm, and 137 (91·3%, 137/150) in the lottery incentivized SST arm were included in the final analysis. The proportion of men who had at least 1 syphilis test during the trial period was 63.4% (95% confidence interval [CI]: 55.5% to 71.3%, p = 0.001) in the standard SST arm, 65.7% (95% CI: 57.7% to 73.6%, p = 0.0002) in the lottery incentivized SST arm, and 14.7% (95% CI: 8.8% to 20.7%, p < 0.001) in the standard of care arm. The estimated RD between the standard SST and standard of care arm was 48.7% (95% CI: 37.8% to 58.4%, p < 0.001). The majority (78.5%, 95% CI: 72.7% to 84.4%, p < 0.001) of syphilis self-testers reported never testing for syphilis. The cost per person tested was US$26.55 for standard SST, US$28.09 for the lottery incentivized SST, and US$66.19 for the standard of care. No study-related adverse events were reported during the study duration. Limitation was that the impact of the Coronavirus Disease 2019 (COVID-19) restrictions may have accentuated demand for decentralized testing.ConclusionsCompared to standard of care, providing SST significantly increased the proportion of MSM testing for syphilis in China and was cheaper (per person tested).Trial registrationChinese Clinical Trial Registry: ChiCTR1900022409. Low syphilis testing uptake is a major public health issue among men who have sex with men (MSM) in many low- and middle-income countries. Syphilis self-testing (SST) may complement and extend facility-based testing. We aimed to evaluate the effectiveness and costs of providing SST on increasing syphilis testing uptake among MSM in China.BACKGROUNDLow syphilis testing uptake is a major public health issue among men who have sex with men (MSM) in many low- and middle-income countries. Syphilis self-testing (SST) may complement and extend facility-based testing. We aimed to evaluate the effectiveness and costs of providing SST on increasing syphilis testing uptake among MSM in China.An open-label, parallel 3-arm randomized controlled trial (RCT) was conducted between January 7, 2020 and July 17, 2020. Men who were at least 18 years of age, had condomless anal sex with men in the past year, reported not testing for syphilis in the last 6 months, and had a stable residence with mailing addresses were recruited from 124 cities in 26 Chinese provinces. Using block randomization with blocks of size 12, enrolled participants were randomly assigned (1:1:1) into 3 arms: standard of care arm, standard SST arm, and lottery incentivized SST arm (1 in 10 chance to win US$15 if they had a syphilis test). The primary outcome was the proportion of participants who tested for syphilis during the trial period and confirmed with photo verification and between arm comparisons were estimated with risk differences (RDs). Analyses were performed on a modified intention-to-treat basis: Participants were included in the complete case analysis if they had initiated at least 1 follow-up survey. The Syphilis/HIV Duo rapid test kit was used. A total of 451 men were enrolled. In total, 136 (90·7%, 136/150) in the standard of care arm, 142 (94·0%, 142/151) in the standard of SST arm, and 137 (91·3%, 137/150) in the lottery incentivized SST arm were included in the final analysis. The proportion of men who had at least 1 syphilis test during the trial period was 63.4% (95% confidence interval [CI]: 55.5% to 71.3%, p = 0.001) in the standard SST arm, 65.7% (95% CI: 57.7% to 73.6%, p = 0.0002) in the lottery incentivized SST arm, and 14.7% (95% CI: 8.8% to 20.7%, p < 0.001) in the standard of care arm. The estimated RD between the standard SST and standard of care arm was 48.7% (95% CI: 37.8% to 58.4%, p < 0.001). The majority (78.5%, 95% CI: 72.7% to 84.4%, p < 0.001) of syphilis self-testers reported never testing for syphilis. The cost per person tested was US$26.55 for standard SST, US$28.09 for the lottery incentivized SST, and US$66.19 for the standard of care. No study-related adverse events were reported during the study duration. Limitation was that the impact of the Coronavirus Disease 2019 (COVID-19) restrictions may have accentuated demand for decentralized testing.METHODS AND FINDINGSAn open-label, parallel 3-arm randomized controlled trial (RCT) was conducted between January 7, 2020 and July 17, 2020. Men who were at least 18 years of age, had condomless anal sex with men in the past year, reported not testing for syphilis in the last 6 months, and had a stable residence with mailing addresses were recruited from 124 cities in 26 Chinese provinces. Using block randomization with blocks of size 12, enrolled participants were randomly assigned (1:1:1) into 3 arms: standard of care arm, standard SST arm, and lottery incentivized SST arm (1 in 10 chance to win US$15 if they had a syphilis test). The primary outcome was the proportion of participants who tested for syphilis during the trial period and confirmed with photo verification and between arm comparisons were estimated with risk differences (RDs). Analyses were performed on a modified intention-to-treat basis: Participants were included in the complete case analysis if they had initiated at least 1 follow-up survey. The Syphilis/HIV Duo rapid test kit was used. A total of 451 men were enrolled. In total, 136 (90·7%, 136/150) in the standard of care arm, 142 (94·0%, 142/151) in the standard of SST arm, and 137 (91·3%, 137/150) in the lottery incentivized SST arm were included in the final analysis. The proportion of men who had at least 1 syphilis test during the trial period was 63.4% (95% confidence interval [CI]: 55.5% to 71.3%, p = 0.001) in the standard SST arm, 65.7% (95% CI: 57.7% to 73.6%, p = 0.0002) in the lottery incentivized SST arm, and 14.7% (95% CI: 8.8% to 20.7%, p < 0.001) in the standard of care arm. The estimated RD between the standard SST and standard of care arm was 48.7% (95% CI: 37.8% to 58.4%, p < 0.001). The majority (78.5%, 95% CI: 72.7% to 84.4%, p < 0.001) of syphilis self-testers reported never testing for syphilis. The cost per person tested was US$26.55 for standard SST, US$28.09 for the lottery incentivized SST, and US$66.19 for the standard of care. No study-related adverse events were reported during the study duration. Limitation was that the impact of the Coronavirus Disease 2019 (COVID-19) restrictions may have accentuated demand for decentralized testing.Compared to standard of care, providing SST significantly increased the proportion of MSM testing for syphilis in China and was cheaper (per person tested).CONCLUSIONSCompared to standard of care, providing SST significantly increased the proportion of MSM testing for syphilis in China and was cheaper (per person tested).Chinese Clinical Trial Registry: ChiCTR1900022409.TRIAL REGISTRATIONChinese Clinical Trial Registry: ChiCTR1900022409. In a multi-arm randomized controlled trial, Cheng Wang and colleagues determine the effectiveness and cost of expanding syphilis self testing among men who have sex with men in China. Background Low syphilis testing uptake is a major public health issue among men who have sex with men (MSM) in many low- and middle-income countries. Syphilis self-testing (SST) may complement and extend facility-based testing. We aimed to evaluate the effectiveness and costs of providing SST on increasing syphilis testing uptake among MSM in China. Methods and findings An open-label, parallel 3-arm randomized controlled trial (RCT) was conducted between January 7, 2020 and July 17, 2020. Men who were at least 18 years of age, had condomless anal sex with men in the past year, reported not testing for syphilis in the last 6 months, and had a stable residence with mailing addresses were recruited from 124 cities in 26 Chinese provinces. Using block randomization with blocks of size 12, enrolled participants were randomly assigned (1:1:1) into 3 arms: standard of care arm, standard SST arm, and lottery incentivized SST arm (1 in 10 chance to win US$15 if they had a syphilis test). The primary outcome was the proportion of participants who tested for syphilis during the trial period and confirmed with photo verification and between arm comparisons were estimated with risk differences (RDs). Analyses were performed on a modified intention-to-treat basis: Participants were included in the complete case analysis if they had initiated at least 1 follow-up survey. The Syphilis/HIV Duo rapid test kit was used. A total of 451 men were enrolled. In total, 136 (90·7%, 136/150) in the standard of care arm, 142 (94·0%, 142/151) in the standard of SST arm, and 137 (91·3%, 137/150) in the lottery incentivized SST arm were included in the final analysis. The proportion of men who had at least 1 syphilis test during the trial period was 63.4% (95% confidence interval [CI]: 55.5% to 71.3%, p = 0.001) in the standard SST arm, 65.7% (95% CI: 57.7% to 73.6%, p = 0.0002) in the lottery incentivized SST arm, and 14.7% (95% CI: 8.8% to 20.7%, p < 0.001) in the standard of care arm. The estimated RD between the standard SST and standard of care arm was 48.7% (95% CI: 37.8% to 58.4%, p < 0.001). The majority (78.5%, 95% CI: 72.7% to 84.4%, p < 0.001) of syphilis self-testers reported never testing for syphilis. The cost per person tested was US$26.55 for standard SST, US$28.09 for the lottery incentivized SST, and US$66.19 for the standard of care. No study-related adverse events were reported during the study duration. Limitation was that the impact of the Coronavirus Disease 2019 (COVID-19) restrictions may have accentuated demand for decentralized testing. Conclusions Compared to standard of care, providing SST significantly increased the proportion of MSM testing for syphilis in China and was cheaper (per person tested). Trial registration Chinese Clinical Trial Registry: ChiCTR1900022409. Low syphilis testing uptake is a major public health issue among men who have sex with men (MSM) in many low- and middle-income countries. Syphilis self-testing (SST) may complement and extend facility-based testing. We aimed to evaluate the effectiveness and costs of providing SST on increasing syphilis testing uptake among MSM in China. An open-label, parallel 3-arm randomized controlled trial (RCT) was conducted between January 7, 2020 and July 17, 2020. Men who were at least 18 years of age, had condomless anal sex with men in the past year, reported not testing for syphilis in the last 6 months, and had a stable residence with mailing addresses were recruited from 124 cities in 26 Chinese provinces. Using block randomization with blocks of size 12, enrolled participants were randomly assigned (1:1:1) into 3 arms: standard of care arm, standard SST arm, and lottery incentivized SST arm (1 in 10 chance to win US$15 if they had a syphilis test). The primary outcome was the proportion of participants who tested for syphilis during the trial period and confirmed with photo verification and between arm comparisons were estimated with risk differences (RDs). Analyses were performed on a modified intention-to-treat basis: Participants were included in the complete case analysis if they had initiated at least 1 follow-up survey. The Syphilis/HIV Duo rapid test kit was used. A total of 451 men were enrolled. In total, 136 (90·7%, 136/150) in the standard of care arm, 142 (94·0%, 142/151) in the standard of SST arm, and 137 (91·3%, 137/150) in the lottery incentivized SST arm were included in the final analysis. The proportion of men who had at least 1 syphilis test during the trial period was 63.4% (95% confidence interval [CI]: 55.5% to 71.3%, p = 0.001) in the standard SST arm, 65.7% (95% CI: 57.7% to 73.6%, p = 0.0002) in the lottery incentivized SST arm, and 14.7% (95% CI: 8.8% to 20.7%, p < 0.001) in the standard of care arm. The estimated RD between the standard SST and standard of care arm was 48.7% (95% CI: 37.8% to 58.4%, p < 0.001). The majority (78.5%, 95% CI: 72.7% to 84.4%, p < 0.001) of syphilis self-testers reported never testing for syphilis. The cost per person tested was US$26.55 for standard SST, US$28.09 for the lottery incentivized SST, and US$66.19 for the standard of care. No study-related adverse events were reported during the study duration. Limitation was that the impact of the Coronavirus Disease 2019 (COVID-19) restrictions may have accentuated demand for decentralized testing. Compared to standard of care, providing SST significantly increased the proportion of MSM testing for syphilis in China and was cheaper (per person tested). Chinese Clinical Trial Registry: ChiCTR1900022409. Background Low syphilis testing uptake is a major public health issue among men who have sex with men (MSM) in many low- and middle-income countries. Syphilis self-testing (SST) may complement and extend facility-based testing. We aimed to evaluate the effectiveness and costs of providing SST on increasing syphilis testing uptake among MSM in China. Methods and findings An open-label, parallel 3-arm randomized controlled trial (RCT) was conducted between January 7, 2020 and July 17, 2020. Men who were at least 18 years of age, had condomless anal sex with men in the past year, reported not testing for syphilis in the last 6 months, and had a stable residence with mailing addresses were recruited from 124 cities in 26 Chinese provinces. Using block randomization with blocks of size 12, enrolled participants were randomly assigned (1:1:1) into 3 arms: standard of care arm, standard SST arm, and lottery incentivized SST arm (1 in 10 chance to win US$15 if they had a syphilis test). The primary outcome was the proportion of participants who tested for syphilis during the trial period and confirmed with photo verification and between arm comparisons were estimated with risk differences (RDs). Analyses were performed on a modified intention-to-treat basis: Participants were included in the complete case analysis if they had initiated at least 1 follow-up survey. The Syphilis/HIV Duo rapid test kit was used. A total of 451 men were enrolled. In total, 136 (90·7%, 136/150) in the standard of care arm, 142 (94·0%, 142/151) in the standard of SST arm, and 137 (91·3%, 137/150) in the lottery incentivized SST arm were included in the final analysis. The proportion of men who had at least 1 syphilis test during the trial period was 63.4% (95% confidence interval [CI]: 55.5% to 71.3%, p = 0.001) in the standard SST arm, 65.7% (95% CI: 57.7% to 73.6%, p = 0.0002) in the lottery incentivized SST arm, and 14.7% (95% CI: 8.8% to 20.7%, p < 0.001) in the standard of care arm. The estimated RD between the standard SST and standard of care arm was 48.7% (95% CI: 37.8% to 58.4%, p < 0.001). The majority (78.5%, 95% CI: 72.7% to 84.4%, p < 0.001) of syphilis self-testers reported never testing for syphilis. The cost per person tested was US$26.55 for standard SST, US$28.09 for the lottery incentivized SST, and US$66.19 for the standard of care. No study-related adverse events were reported during the study duration. Limitation was that the impact of the Coronavirus Disease 2019 (COVID-19) restrictions may have accentuated demand for decentralized testing. Conclusions Compared to standard of care, providing SST significantly increased the proportion of MSM testing for syphilis in China and was cheaper (per person tested). Trial registration Chinese Clinical Trial Registry: ChiCTR1900022409. |
| Audience | Academic |
| Author | Weideman, Ann Marie Cheng, Weibin Fu, Hongyun Terris-Prestholt, Fern Marks, Michael Zhao, Peizhen Tang, Weiming Ong, Jason J. Tucker, Joseph D. Wang, Cheng Smith, M. Kumi Zheng, Heping Yang, Bin |
| AuthorAffiliation | 10 Department of Global Health and Development, London School of Hygiene & Tropical Medicine, London, United Kingdom 7 University of North Carolina Project-China, Guangzhou, Guangdong, China 2 Southern Medical University Institute for Global Health and Sexually Transmitted Diseases, Guangzhou, Guangdong, China 8 Division of Epidemiology and Community Health, University of Minnesota Twin Cities, Minneapolis, Minnesota, United States of America Boston University School of Public Health, UNITED STATES 1 Dermatology Hospital of Southern Medical University, Guangzhou, Guangdong, China 5 Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America 11 Institute for Global Health and Infectious Diseases, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America 3 Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdom 6 |
| AuthorAffiliation_xml | – name: 7 University of North Carolina Project-China, Guangzhou, Guangdong, China – name: 9 Division of Community Health and Research, Eastern Virginia Medical School, Norfolk, Virginia, United States of America – name: 8 Division of Epidemiology and Community Health, University of Minnesota Twin Cities, Minneapolis, Minnesota, United States of America – name: 2 Southern Medical University Institute for Global Health and Sexually Transmitted Diseases, Guangzhou, Guangdong, China – name: 3 Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdom – name: 1 Dermatology Hospital of Southern Medical University, Guangzhou, Guangdong, China – name: 4 Central Clinical School, Monash University, Victoria, Melbourne, Australia – name: Boston University School of Public Health, UNITED STATES – name: 5 Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America – name: 10 Department of Global Health and Development, London School of Hygiene & Tropical Medicine, London, United Kingdom – name: 6 Center for AIDS Research Biostatistics Core, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America – name: 11 Institute for Global Health and Infectious Diseases, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America |
| Author_xml | – sequence: 1 givenname: Cheng orcidid: 0000-0001-8000-9969 surname: Wang fullname: Wang, Cheng – sequence: 2 givenname: Jason J. orcidid: 0000-0001-5784-7403 surname: Ong fullname: Ong, Jason J. – sequence: 3 givenname: Peizhen surname: Zhao fullname: Zhao, Peizhen – sequence: 4 givenname: Ann Marie orcidid: 0000-0002-1653-9102 surname: Weideman fullname: Weideman, Ann Marie – sequence: 5 givenname: Weiming orcidid: 0000-0002-9026-707X surname: Tang fullname: Tang, Weiming – sequence: 6 givenname: M. Kumi orcidid: 0000-0001-5861-8100 surname: Smith fullname: Smith, M. Kumi – sequence: 7 givenname: Michael orcidid: 0000-0002-7585-4743 surname: Marks fullname: Marks, Michael – sequence: 8 givenname: Hongyun orcidid: 0000-0002-9964-023X surname: Fu fullname: Fu, Hongyun – sequence: 9 givenname: Weibin orcidid: 0000-0002-9845-6676 surname: Cheng fullname: Cheng, Weibin – sequence: 10 givenname: Fern orcidid: 0000-0003-1693-5196 surname: Terris-Prestholt fullname: Terris-Prestholt, Fern – sequence: 11 givenname: Heping orcidid: 0000-0002-9846-975X surname: Zheng fullname: Zheng, Heping – sequence: 12 givenname: Joseph D. orcidid: 0000-0003-2804-1181 surname: Tucker fullname: Tucker, Joseph D. – sequence: 13 givenname: Bin surname: Yang fullname: Yang, Bin |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/35235573$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1136/sextrans-2017-053301 10.1016/j.eclinm.2020.100440 10.1093/cid/ciz603 10.1097/01.olq.0000149783.67826.4d 10.1111/hiv.12437 10.1007/s10461-006-9172-9 10.1097/QAD.0000000000001705 10.1080/14787210.2016.1236683 10.1016/S1473-3099(10)70092-X 10.2471/BLT.09.070326 10.1371/journal.pone.0159309 10.1136/sextrans-2019-054072 10.1093/biomet/86.4.948 10.1007/s10461-010-9808-7 10.1177/0956462417717649 10.1071/SH19044 10.1016/S2214-109X(20)30070-X 10.1371/journal.pmed.1002645 10.1097/OLQ.0000000000000737 10.2471/BLT.18.228486 10.1093/cid/cix326 10.1201/b19428 10.1371/journal.pone.0090347 10.1186/s12879-020-05188-z 10.1371/journal.pone.0188890 10.1002/jia2.25255 10.1093/cid/ciz331 10.1186/s12889-018-6090-5 10.1002/jia2.25243 10.1186/s12992-018-0419-9 10.1071/SH14156 10.1007/s10461-013-0588-8 10.1080/14787210.2018.1463846 10.1111/j.0006-341X.1999.01202.x |
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| References | W Cheng (pmed.1003930.ref019) 2020; 20 C Mangenah (pmed.1003930.ref033) 2019; 22 MM Taylor (pmed.1003930.ref040) 2017; 93 HH Ayoub (pmed.1003930.ref023) 2018; 3 HW Chesson (pmed.1003930.ref031) 2017 R Lee (pmed.1003930.ref017) 2014; 18 WE Abara (pmed.1003930.ref002) 2016; 11 R Turpin (pmed.1003930.ref008) 2020; 17 T. Raghunathan (pmed.1003930.ref027) 2015 BM Halpaap (pmed.1003930.ref014) 2020; 8 F Zhong (pmed.1003930.ref021) 2017; 18 V Cambiano (pmed.1003930.ref032) 2019; 22 JJ Ong (pmed.1003930.ref018) 2020; 96 JD Tucker (pmed.1003930.ref011) 2010; 10 JP Bil (pmed.1003930.ref028) 2017; 7 pmed.1003930.ref024 MD Pham (pmed.1003930.ref042) 2020; 24 JJ Ong (pmed.1003930.ref009) 2018; 16 IS Chan (pmed.1003930.ref025) 1999; 55 EE Kpokiri (pmed.1003930.ref012) 2020 CP Roberts (pmed.1003930.ref038) 2016; 14 W Pequegnat (pmed.1003930.ref035) 2007; 11 EL Giles (pmed.1003930.ref016) 2014; 9 J Rowley (pmed.1003930.ref001) 2019; 97 Y Qin (pmed.1003930.ref020) 2018; 32 TA Peterman (pmed.1003930.ref030) 2015; 12 TA Peterman (pmed.1003930.ref041) 2018; 45 C Wang (pmed.1003930.ref004) 2020; 70 DK Levine (pmed.1003930.ref010) 2005; 32 Y Guo (pmed.1003930.ref037) 2011; 15 JD Tucker (pmed.1003930.ref006) 2010; 88 AL Yingpeng Qiu (pmed.1003930.ref034) 2013; 32 J Barnard (pmed.1003930.ref026) 1999; 86 W Tang (pmed.1003930.ref003) 2018; 15 Y Tao (pmed.1003930.ref005) 2020; 70 WM Sweileh (pmed.1003930.ref013) 2018; 14 C Zhang (pmed.1003930.ref029) 2017; 12 J Holden (pmed.1003930.ref022) 2018; 29 pmed.1003930.ref039 EPF Chow (pmed.1003930.ref007) 2017; 65 pmed.1003930.ref015 C Wang (pmed.1003930.ref036) 2018; 18 35926169 - PLoS Med. 2022 Aug 4;19(8):e1004071. doi: 10.1371/journal.pmed.1004071. |
| References_xml | – volume: 93 start-page: 458 issue: 7 year: 2017 ident: pmed.1003930.ref040 article-title: Role of dual HIV/syphilis test kits in expanding syphilis screening publication-title: Sex Transm Infect doi: 10.1136/sextrans-2017-053301 – volume: 24 start-page: 100440 year: 2020 ident: pmed.1003930.ref042 article-title: Improving the coverage and accuracy of syphilis testing: The development of a novel rapid, point-of-care test for confirmatory testing of active syphilis infection and its early evaluation in China and South Africa. publication-title: EClinicalMedicine doi: 10.1016/j.eclinm.2020.100440 – volume: 70 start-page: 2178 issue: 10 year: 2020 ident: pmed.1003930.ref004 article-title: Syphilis self-testing: a nationwide pragmatic study among men who have sex with men in China publication-title: Clin Infect Dis doi: 10.1093/cid/ciz603 – volume: 32 start-page: 139 issue: 2 year: 2005 ident: pmed.1003930.ref010 article-title: Online syphilis testing—confidential and convenient publication-title: Sex Transm Dis doi: 10.1097/01.olq.0000149783.67826.4d – volume: 18 start-page: 376 issue: 5 year: 2017 ident: pmed.1003930.ref021 article-title: Acceptability and feasibility of a social entrepreneurship testing model to promote HIV self-testing and linkage to care among men who have sex with men. publication-title: HIV Med doi: 10.1111/hiv.12437 – volume: 11 start-page: 505 issue: 4 year: 2007 ident: pmed.1003930.ref035 article-title: Conducting Internet-based HIV/STD prevention survey research: considerations in design and evaluation publication-title: AIDS and Behav doi: 10.1007/s10461-006-9172-9 – volume: 32 start-page: 371 issue: 3 year: 2018 ident: pmed.1003930.ref020 article-title: Experiences using and organizing HIV self-testing publication-title: AIDS doi: 10.1097/QAD.0000000000001705 – volume: 14 start-page: 1037 issue: 11 year: 2016 ident: pmed.1003930.ref038 article-title: Global challenges in human immunodeficiency virus and syphilis coinfection among men who have sex with men publication-title: Expert Rev Anti Infect Ther doi: 10.1080/14787210.2016.1236683 – volume: 10 start-page: 381 issue: 6 year: 2010 ident: pmed.1003930.ref011 article-title: Accelerating worldwide syphilis screening through rapid testing: a systematic review publication-title: Lancet Infect Dis doi: 10.1016/S1473-3099(10)70092-X – volume: 88 start-page: 452 year: 2010 ident: pmed.1003930.ref006 article-title: Scaling up syphilis testing in China: implementation beyond the clinic publication-title: Bull World Health Organ doi: 10.2471/BLT.09.070326 – ident: pmed.1003930.ref015 – volume: 11 start-page: e0159309 issue: 7 year: 2016 ident: pmed.1003930.ref002 article-title: Syphilis trends among men who have sex with men in the United States and Western Europe: a systematic review of trend studies published between 2004 and 2015 publication-title: PLoS ONE doi: 10.1371/journal.pone.0159309 – volume: 3 start-page: 373 issue: 101692406 year: 2018 ident: pmed.1003930.ref023 article-title: Use of routine HIV testing data for early detection of emerging HIV epidemics in high-risk subpopulations: A concept demonstration study publication-title: Infect Dis Model – volume: 96 start-page: 355 issue: 5 year: 2020 ident: pmed.1003930.ref018 article-title: Risk attitudes, risky sexual behaviours and willingness to test negative for syphilis using lottery-based financial incentives among Chinese men who have sex with men publication-title: Sex Transm Dis doi: 10.1136/sextrans-2019-054072 – volume: 86 start-page: 948 issue: 4 year: 1999 ident: pmed.1003930.ref026 article-title: Miscellanea. Small-sample degrees of freedom with multiple imputation publication-title: Biometrika doi: 10.1093/biomet/86.4.948 – volume: 15 start-page: 521 issue: 3 year: 2011 ident: pmed.1003930.ref037 article-title: HIV-related behavioral studies of men who have sex with men in China: a systematic review and recommendations for future research publication-title: AIDS Behav doi: 10.1007/s10461-010-9808-7 – volume: 29 start-page: 57 issue: 1 year: 2018 ident: pmed.1003930.ref022 article-title: An evaluation of the SD Bioline HIV/syphilis duo test publication-title: Int J STD AIDS doi: 10.1177/0956462417717649 – volume: 17 start-page: 201 issue: 3 year: 2020 ident: pmed.1003930.ref008 article-title: Barriers to syphilis testing among men who have sex with men: a systematic review of the literature publication-title: Sex Health doi: 10.1071/SH19044 – volume: 8 start-page: e633 issue: 5 year: 2020 ident: pmed.1003930.ref014 article-title: Social innovation in global health: sparking location action publication-title: Lancet Glob Health doi: 10.1016/S2214-109X(20)30070-X – volume: 15 start-page: e1002645 issue: 8 year: 2018 ident: pmed.1003930.ref003 article-title: Crowdsourcing to expand HIV testing among men who have sex with men in China: a closed cohort stepped wedge cluster randomized controlled trial publication-title: PLoS Med doi: 10.1371/journal.pmed.1002645 – volume: 45 start-page: e7 issue: 3 year: 2018 ident: pmed.1003930.ref041 article-title: Preparing for the Chlamydia and Gonorrhea Self-Test. publication-title: Sex Transm Dis doi: 10.1097/OLQ.0000000000000737 – volume: 97 start-page: 548 issue: 8 year: 2019 ident: pmed.1003930.ref001 article-title: Chlamydia, gonorrhoea, trichomoniasis and syphilis: global prevalence and incidence estimates, 2016 publication-title: Bull World Health Organ doi: 10.2471/BLT.18.228486 – volume: 7 issue: 9 year: 2017 ident: pmed.1003930.ref028 article-title: Usage of purchased self-tests for HIV and sexually transmitted infections in Amsterdam, the Netherlands: results of population-based and serial cross-sectional studies among the general population and sexual risk groups publication-title: BMJ Open – volume: 65 start-page: 389 issue: 3 year: 2017 ident: pmed.1003930.ref007 article-title: Increased syphilis testing of men who have sex with men: greater detection of asymptomatic early syphilis and relative reduction in secondary syphilis publication-title: Clin Infect Dis doi: 10.1093/cid/cix326 – volume-title: Missing data analysis in practice year: 2015 ident: pmed.1003930.ref027 doi: 10.1201/b19428 – volume: 9 start-page: e90347 issue: 3 year: 2014 ident: pmed.1003930.ref016 article-title: The effectiveness of financial incentives for health behaviour change: systematic review and meta-analysis publication-title: PLoS ONE doi: 10.1371/journal.pone.0090347 – volume: 20 start-page: 1 issue: 1 year: 2020 ident: pmed.1003930.ref019 article-title: Promoting routine syphilis screening among men who have sex with men in China: study protocol for a randomised controlled trial of syphilis self-testing and lottery incentive publication-title: BMC Infect Dis doi: 10.1186/s12879-020-05188-z – volume: 12 start-page: e0188890 issue: 11 year: 2017 ident: pmed.1003930.ref029 article-title: Can self-testing increase HIV testing among men who have sex with men: A systematic review and meta-analysis publication-title: PLoS ONE doi: 10.1371/journal.pone.0188890 – ident: pmed.1003930.ref039 – volume: 22 start-page: e25255 issue: Suppl 1 year: 2019 ident: pmed.1003930.ref033 article-title: Economic cost analysis of door-to-door community-based distribution of HIV self-test kits in Malawi, Zambia and Zimbabwe publication-title: J Int AIDS Soc doi: 10.1002/jia2.25255 – volume: 70 start-page: 136 issue: 1 year: 2020 ident: pmed.1003930.ref005 article-title: A Nationwide Spatiotemporal Analysis of Syphilis Over 21 Years and Implications for Prevention and Control in China publication-title: Clin Infect Dis doi: 10.1093/cid/ciz331 – volume: 18 start-page: 1175 issue: 1 year: 2018 ident: pmed.1003930.ref036 article-title: Condom use social norms and self-efficacy with different kinds of male partners among Chinese men who have sex with men: results from an online survey publication-title: BMC Public Health doi: 10.1186/s12889-018-6090-5 – volume-title: Major Infectious Diseases year: 2017 ident: pmed.1003930.ref031 – volume: 22 start-page: e25243 issue: Suppl 1 year: 2019 ident: pmed.1003930.ref032 article-title: The impact and cost-effectiveness of community-based HIV self-testing in sub-Saharan Africa: a health economic and modelling analysis publication-title: J Int AIDS Soc doi: 10.1002/jia2.25243 – volume: 14 start-page: 105 issue: 1 year: 2018 ident: pmed.1003930.ref013 article-title: Global output of research on the health of international migrant workers from 2000 to 2017 publication-title: Glob Health doi: 10.1186/s12992-018-0419-9 – volume: 12 start-page: 126 issue: 2 year: 2015 ident: pmed.1003930.ref030 article-title: Public health interventions to control syphilis publication-title: Sex Health doi: 10.1071/SH14156 – year: 2020 ident: pmed.1003930.ref012 article-title: Diagnostic infectious diseases testing outside clinics: A global systematic review and meta-analysis publication-title: Open Forum Infect Dis – volume: 18 start-page: 905 issue: 5 year: 2014 ident: pmed.1003930.ref017 article-title: Incentivizing HIV/STI testing: a systematic review of the literature publication-title: AIDS Behav doi: 10.1007/s10461-013-0588-8 – volume: 16 start-page: 423 issue: 5 year: 2018 ident: pmed.1003930.ref009 article-title: Expanding syphilis testing: a scoping review of syphilis testing interventions among key populations publication-title: Expert Rev Anti Infect Ther doi: 10.1080/14787210.2018.1463846 – ident: pmed.1003930.ref024 – volume: 55 start-page: 1202 issue: 4 year: 1999 ident: pmed.1003930.ref025 article-title: Test-based exact confidence intervals for the difference of two binomial proportions publication-title: Biometrics doi: 10.1111/j.0006-341X.1999.01202.x – volume: 32 start-page: 3 issue: 12 year: 2013 ident: pmed.1003930.ref034 article-title: Analysis on the Cost -Effectiveness of Syphilis Intervention Project for Homosexuals in Clinics of Shenzhen publication-title: Chinese. Health Econ – reference: 35926169 - PLoS Med. 2022 Aug 4;19(8):e1004071. doi: 10.1371/journal.pmed.1004071. |
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| Snippet | Low syphilis testing uptake is a major public health issue among men who have sex with men (MSM) in many low- and middle-income countries. Syphilis... Background Low syphilis testing uptake is a major public health issue among men who have sex with men (MSM) in many low- and middle-income countries. Syphilis... In a multi-arm randomized controlled trial, Cheng Wang and colleagues determine the effectiveness and cost of expanding syphilis self testing among men who... BackgroundLow syphilis testing uptake is a major public health issue among men who have sex with men (MSM) in many low- and middle-income countries. Syphilis... Background Low syphilis testing uptake is a major public health issue among men who have sex with men (MSM) in many low- and middle-income countries. Syphilis... |
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| SubjectTerms | Adolescent Adult Anal sex Antibodies Behavior Biology and Life Sciences China - epidemiology Clinical trials Consent Coronaviruses COVID-19 COVID-19 - epidemiology Crowdsourcing Disease transmission Enrollments Follow-Up Studies Health aspects Health facilities Health promotion Health Services Accessibility - organization & administration HIV HIV Infections - diagnosis HIV Infections - prevention & control Home medical tests Homosexuality, Male - statistics & numerical data Human immunodeficiency virus Humans Immunoassay - methods Immunoglobulins Incentives Male Mass Screening - economics Mass Screening - methods Mass Screening - organization & administration Medicine and Health Sciences Methods Middle Aged Monetary incentives Motivation MSM (Men who have sex with men) Pandemics Patient Participation - methods People and Places Public health Reagent Kits, Diagnostic - economics Reagent Kits, Diagnostic - supply & distribution Research and Analysis Methods SARS-CoV-2 Self-Testing Sexual and Gender Minorities - statistics & numerical data Social networks Social research Standard of care Syphilis Syphilis - diagnosis Syphilis - epidemiology Syphilis - prevention & control Young Adult |
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| Title | Expanding syphilis test uptake using rapid dual self-testing for syphilis and HIV among men who have sex with men in China: A multiarm randomized controlled trial |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/35235573 https://www.proquest.com/docview/2651153135 https://www.proquest.com/docview/2635475758 https://pubmed.ncbi.nlm.nih.gov/PMC8890628 https://doaj.org/article/fe466637e26f48089462d50a53e0406c http://dx.doi.org/10.1371/journal.pmed.1003930 |
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